Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Joseph Yanni"'
Autor:
Luca Soattin, Zoltan Borbas, Jane Caldwell, Brian Prendergast, Akbar Vohra, Yawer Saeed, Andreas Hoschtitzky, Joseph Yanni, Andrew Atkinson, Sunil Jit Logantha, Balint Borbas, Clifford Garratt, Gwilym Matthew Morris, Halina Dobrzynski
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
BackgroundThe sinoatrial/sinus node (SAN) is the primary pacemaker of the heart. In humans, SAN is surrounded by the paranodal area (PNA). Although the PNA function remains debated, it is thought to act as a subsidiary atrial pacemaker (SAP) tissue a
Externí odkaz:
https://doaj.org/article/6b3dac3fc6cd4f44acddbf2489a131a0
Autor:
Maria Petkova, Andrew J. Atkinson, Joseph Yanni, Luke Stuart, Abimbola J. Aminu, Alexandra D. Ivanova, Ksenia B. Pustovit, Connor Geragthy, Amy Feather, Ning Li, Yu Zhang, Delvac Oceandy, Filip Perde, Peter Molenaar, Alicia D’Souza, Vadim V. Fedorov, Halina Dobrzynski
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 20 (2020)
Background The sinus node (SN) is the primary pacemaker of the heart. SN myocytes possess distinctive action potential morphology with spontaneous diastolic depolarization because of a unique expression of ion channels and Ca2+‐handling proteins. M
Externí odkaz:
https://doaj.org/article/375542e1a34747dcbe6c389f36654b67
Autor:
Yu Zhang, Yanwen Wang, Joseph Yanni, Mohammed Anwar Qureshi, Sunil Jit R. J. Logantha, Sarah Kassab, Mark R. Boyett, Natalie J. Gardiner, Hong Sun, Frank Christopher Howarth, Halina Dobrzynski
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Cardiovascular complications are common in type 1 diabetes mellitus (TIDM) and there is an increased risk of arrhythmias as a result of dysfunction of the cardiac conduction system (CCS). We have previously shown that, in vivo, there is a decrease in
Externí odkaz:
https://doaj.org/article/fdf04a20ee5b429b86f091954f28f4c9
Autor:
Reza Ashrafi, Marianne Yon, Lucy Pickavance, Joseph Yanni Gerges, Gershan Davis, John Wilding, Kun Jian, Henggui Zhang, George Hart, Mark Boyett
Publikováno v:
Journal of Obesity, Vol 2016 (2016)
Introduction. Obesity is increasingly common and is associated with an increased prevalence of cardiac arrhythmias. The aim of this study was to see whether in obesity there is proarrhythmic gene expression of ventricular ion channels and related mol
Externí odkaz:
https://doaj.org/article/e732b0233ea045aab2aaf92dc199b56e
Autor:
Mohammad reza Nikmaram, Joseph Yanni
Publikováno v:
Iranian South Medical Journal, Vol 11, Iss 1, Pp 1-7 (2008)
Background: Sinoatrial node (SAN) is the primary pacemaker of the heart. If the SAN activity fails in any way, then the atrioventricular node (AVN) immediately starts to regulate the activities of the heart. The aim of this study was to assess the ex
Externí odkaz:
https://doaj.org/article/70a6472c9faa4c29b898611635cfc5f2
Autor:
Theodora Nikolaidou, Xue J Cai, Robert S Stephenson, Joseph Yanni, Tristan Lowe, Andrew J Atkinson, Caroline B Jones, Rida Sardar, Antonio F Corno, Halina Dobrzynski, Philip J Withers, Jonathan C Jarvis, George Hart, Mark R Boyett
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141452 (2015)
Heart failure is a major killer worldwide. Atrioventricular conduction block is common in heart failure; it is associated with worse outcomes and can lead to syncope and bradycardic death. We examine the effect of heart failure on anatomical and ion
Externí odkaz:
https://doaj.org/article/d33c3f6f1d1b40f3a4dd15ab952a257b
Autor:
Sunil Jit R. J. Logantha, Tomoko T. Yamanushi, Mais Absi, Ian P. Temple, Hideaki Kabuto, Eiichiro Hirakawa, Gillian Quigley, X. Zhang, Alison M. Gurney, George Hart, Henggui Zhang, Halina Dobrzynski, Mark R. Boyett, Joseph Yanni
Patients with pulmonary arterial hypertension (PAH) have a high burden of arrhythmias, including arrhythmias arising from sinus node dysfunction, and the aim of this study was to investigate the effects of PAH on the sinus node. In the rat, PAH was i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5291290fb66dce06b8def2fd3c54a65d
Autor:
Sunil Jit R.J. Logantha, James O. Tellez, Mark R. Boyett, Eman S.H. Abd Allah, Cali Anderson, P. Mesirca, Natalie Chandler, Matthew K. Lancaster, Matteo E. Mangoni, Joseph Yanni, George Hart, Jonathan P. Ariyaratnam, Matthew Smith, Henggui Zhang, Robert S. Stephenson, Luke Stuart, Gwilym M. Morris, Claire Wilson, Xue Cai, Rudi Billeter, Alicia D'Souza, Annalisa Bucchi, Sandra C. Jones, Oliver J. Monfredi, Carol T. Bussey, Shu Nakao
Publikováno v:
Progress in Biophysics and Molecular Biology
Progress in Biophysics and Molecular Biology, Elsevier, 2021, 166, pp.61-85. ⟨10.1016/j.pbiomolbio.2021.06.008⟩
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Boyett, M, Yanni Gerges, J, Tellez, J O, Bucchi, A, Mesirca, P, Cai, X, Logantha, S J R J, Wilson, C, Anderson, C, Ariyaratnam, J, Stuart, L, Nakao, S, Allah, E A, Jones, S A, Lancaster, M, Stephenson, R S, Chandler, N, Smith, M, Bussey, C, Monfredi, O, Morris, G, Billeter, R, Mangoni, M E, Zhang, H, Hart, G & D'Souza, A 2021, ' Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease ', Progress in biophysics and molecular biology, vol. 166, pp. 61-85 . https://doi.org/10.1016/j.pbiomolbio.2021.06.008
Progress in Biophysics and Molecular Biology, Elsevier, 2021, 166, pp.61-85. ⟨10.1016/j.pbiomolbio.2021.06.008⟩
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Boyett, M, Yanni Gerges, J, Tellez, J O, Bucchi, A, Mesirca, P, Cai, X, Logantha, S J R J, Wilson, C, Anderson, C, Ariyaratnam, J, Stuart, L, Nakao, S, Allah, E A, Jones, S A, Lancaster, M, Stephenson, R S, Chandler, N, Smith, M, Bussey, C, Monfredi, O, Morris, G, Billeter, R, Mangoni, M E, Zhang, H, Hart, G & D'Souza, A 2021, ' Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease ', Progress in biophysics and molecular biology, vol. 166, pp. 61-85 . https://doi.org/10.1016/j.pbiomolbio.2021.06.008
The funny current, I f, was first recorded in the heart 40 or more years ago by Dario DiFrancesco and others. Since then, we have learnt that I f plays an important role in pacemaking in the sinus node, the innate pacemaker of the heart, and more rec
Autor:
Vladislav S. Kuzmin, Weixuan Chen, Filip Virgil Perde, Mateusz K. Hołda, Halina Dobrzynski, Abimbola J. Aminu, Marcin Kuniewicz, Peter C. M. Molenaar, Andrew Atkinson, Robert T. Simms, Maria Petkova, Joseph Yanni, Zeyuan Yin, Alex D. Morris
Publikováno v:
Aminu, A J, Petkova, M, Atkinson, A J, Yanni, J, Morris, A D, Simms, R T, Chen, W, Yin, Z, Kuniewicz, M, Holda, M K, Kuzmin, V S, Perde, F, Molenaar, P & Dobrzynski, H 2021, ' Further insights into the molecular complexity of the human sinus node-The role of 'novel' transcription factors and microRNAs ', Progress in biophysics and molecular biology, vol. 166, pp. 86-104 . https://doi.org/10.1016/j.pbiomolbio.2021.04.008
RESEARCH PURPOSE: The sinus node (SN) is the heart's primary pacemaker. Key ion channels (mainly the funny channel, HCN4) and Ca2+-handling proteins in the SN are responsible for its function. Transcription factors (TFs) regulate gene expression thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7700c0b2042feec85a0e70f3fae4ba89
https://doi.org/10.1016/j.pbiomolbio.2021.04.008
https://doi.org/10.1016/j.pbiomolbio.2021.04.008
Autor:
Sunil Jit R. J. Logantha, Joseph Yanni, Ashraf Kitmitto, Oliver J. Monfredi, Luke Stuart, Akbar Vohra, Shu Nakao, R Hutcheon, Tobias Starborg, Caroline Jones, GM Quigley, George Hart, Robert S. Stephenson, Jonathan C. Jarvis, X. Cai, Antonio F. Corno, Il Young Oh, Halina Dobrzynski, Mark R. Boyett
Publikováno v:
Circulation. Heart Failure
Logantha, S J R J, Cai, X J, Yanni, J, Jones, C B, Stephenson, R S, Stuart, L, Quigley, G, Monfredi, O, Nakao, S, Oh, I Y, Starborg, T, Kitmitto, A, Vohra, A, Hutcheon, R C, Corno, A F, Jarvis, J C, Dobrzynski, H, Boyett, M R & Hart, G 2021, ' Remodeling of the Purkinje Network in Congestive Heart Failure in the Rabbit ', Circulation. Heart Failure, vol. 14, no. 7, pp. 800-816 . https://doi.org/10.1161/CIRCHEARTFAILURE.120.007505
Logantha, S J R J, Cai, X J, Yanni, J, Jones, C B, Stephenson, R S, Stuart, L, Quigley, G, Monfredi, O, Nakao, S, Oh, I Y, Starborg, T, Kitmitto, A, Vohra, A, Hutcheon, R C, Corno, A F, Jarvis, J C, Dobrzynski, H, Boyett, M R & Hart, G 2021, ' Remodeling of the Purkinje Network in Congestive Heart Failure in the Rabbit ', Circulation. Heart Failure, vol. 14, no. 7, pp. 800-816 . https://doi.org/10.1161/CIRCHEARTFAILURE.120.007505
Supplemental Digital Content is available in the text.
Background: Purkinje fibers (PFs) control timing of ventricular conduction and play a key role in arrhythmogenesis in heart failure (HF) patients. We investigated the effects of HF on PFs. M
Background: Purkinje fibers (PFs) control timing of ventricular conduction and play a key role in arrhythmogenesis in heart failure (HF) patients. We investigated the effects of HF on PFs. M