Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Joseph Xu"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 7, p e1010319 (2022)
Intratumor cellular heterogeneity and non-genetic cell plasticity in tumors pose a recently recognized challenge to cancer treatment. Because of the dispersion of initial cell states within a clonal tumor cell population, a perturbation imparted by a
Externí odkaz:
https://doaj.org/article/efe55d48844b4396a90945a09c758a62
Autor:
Ceren Ozkul, Victoria E. Ruiz, Thomas Battaglia, Joseph Xu, Claire Roubaud-Baudron, Ken Cadwell, Guillermo I. Perez-Perez, Martin J. Blaser
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-16 (2020)
Abstract Background There is increasing evidence that the intestinal microbiota plays a crucial role in the maturation of the immune system and the prevention of diseases during childhood. Early-life short-course antibiotic use may affect the progres
Externí odkaz:
https://doaj.org/article/d6624822803949d1a881009a7b786522
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100806 (2014)
MicroRNAs (miRNAs) have attracted a great deal of attention in biology and medicine. It has been hypothesized that miRNAs interact with transcription factors (TFs) in a coordinated fashion to play key roles in regulating signaling and transcriptional
Externí odkaz:
https://doaj.org/article/f37ac31a28e3483eac6b3722b396ca8e
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e110714 (2014)
Tumorigenesis is a dynamic biological process that involves distinct cancer cell subpopulations proliferating at different rates and interconverting between them. In this paper we proposed a mathematical framework of population dynamics that consider
Externí odkaz:
https://doaj.org/article/6dfbe34fd0414c62bef4a64d99e9fdba
Predicting pancreas cell fate decisions and reprogramming with a hierarchical multi-attractor model.
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e14752 (2011)
Cell fate reprogramming, such as the generation of insulin-producing β cells from other pancreas cells, can be achieved by external modulation of key transcription factors. However, the known gene regulatory interactions that form a complex network
Externí odkaz:
https://doaj.org/article/d4dc889e7d6b430ab3adb6d96acbf2f3
Publikováno v:
Biosystems 142-143:15-24 (2016)
Progress in cell type reprogramming has revived the interest in Waddington's concept of the epigenetic landscape. Recently researchers developed the quasi-potential theory to represent the Waddington's landscape. The Quasi-potential U(x), derived fro
Externí odkaz:
http://arxiv.org/abs/1407.6117
Developmental dynamics of multicellular organism is a process that takes place in a multi-stable system in which each attractor state represents a cell type and attractor transitions correspond to cell differentiation paths. This new understanding ha
Externí odkaz:
http://arxiv.org/abs/1206.2311
Publikováno v:
In BioSystems April-May 2016 142-143:15-24
Publikováno v:
Proceedings of the AAAI Conference on Artificial Intelligence and Interactive Digital Entertainment. 3:55-60
We developed knowledge-rich agents to play real-time strategy games by interfacing the ORTS game engine to the Soar cognitive architecture. The middleware we developed supports grouping, attention, coordinated path finding, and FSM control of low-lev
Akademický článek
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