Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Joseph Ware"'
Autor:
Diansong Zhou, Terry Podoll, Yan Xu, Ganesh Moorthy, Karthick Vishwanathan, Joseph Ware, J. Greg Slatter, Nidal Al‐Huniti
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 7, Pp 489-499 (2019)
Acalabrutinib, a selective, covalent Bruton tyrosine kinase inhibitor, is a CYP3A substrate and weak CYP3A/CYP2C8 inhibitor. A physiologically‐based pharmacokinetic (PBPK) model was developed for acalabrutinib and its active metabolite ACP‐5862 t
Externí odkaz:
https://doaj.org/article/3dd18b63fb5f4449a581ca63c1046d47
Autor:
Shuguang Ma, Sungjoon Cho, Srikumar Sahasranaman, Weiping Zhao, Jodie Pang, Xiao Ding, Brian Dean, Bin Wang, Jerry Y. Hsu, Joseph Ware, Laurent Salphati
Publikováno v:
Drug Metabolism and Disposition. 51:436-450
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdf16c475c39101aef67df335d26c42f
https://doi.org/10.1124/dmd.122.001096
https://doi.org/10.1124/dmd.122.001096
Autor:
Buyun Chen, Diansong Zhou, Hua Wei, Marmor Yotvat, Li Zhou, Jean Cheung, Nicole Sarvaria, Richard Lai, Shringi Sharma, Karthick Vishwanathan, Joseph Ware
Publikováno v:
British Journal of Clinical Pharmacology. 88:3716-3729
Clinical drug interaction studies with itraconazole and rifampicin have demonstrated that acalabrutinib is a sensitive substrate of CYP3A. A physiologically based pharmacokinetic (PBPK) model was developed based on the data of these studies. One of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0edefe51624fa6f522462d992b5dcca2
https://doi.org/10.1111/bcp.15278
https://doi.org/10.1111/bcp.15278
Autor:
Zhongqing He, Shringi Sharma, Joseph Ware, Helena Edlund, Helen Wei, Núria Buil-Bruna, Marshall Baek, Helen Tomkinson, Karthick Vishwanathan, Miné de Kock, Rakesh K. Raman, Huan Liu, Priti Patel
Publikováno v:
British Journal of Clinical Pharmacology. 88:2284-2296
Aims Examine relationships between the systemic exposure of acalabrutinib, a highly selective, next-generation Bruton tyrosine kinase inhibitor, and its active metabolite (ACP-5862) vs. efficacy and safety responses in patients with B-cell malignanci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d661a62dde63d808a29a323a3d8a1f34
https://doi.org/10.1111/bcp.15087
https://doi.org/10.1111/bcp.15087
Autor:
Dermot F. McGinnity, Diansong Zhou, Shringi Sharma, Buyun Chen, Venkatesh Pilla Reddy, Karthick Vishwanathan, Adrian J. Fretland, Joseph Ware, Yan Xu
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Limited information is available regarding the drug–drug interaction (DDI) potential of molecular targeted agents and rituximab plus cyclophosphamide, doxorubicin (hydroxydaunorubicin), vincristine (Oncovin), and prednisone (R-CHOP) therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7423484d01bb4cf3c2bc3d7963e512
https://doi.org/10.1007/s00280-021-04302-5
https://doi.org/10.1007/s00280-021-04302-5
Slowing the transmission of SARS-CoV-2 requires rapid and accurate diagnostic testing. Toward this end, loop-mediated isothermal amplification (LAMP), an isothermal genomic detection method, offers great promise but the readout tends to be difficult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d9b82fd89a5713e5f5892577eba30f1
https://doi.org/10.1101/2022.04.04.487067
https://doi.org/10.1101/2022.04.04.487067
Autor:
Francesco Bellanti, Núria Buil-Bruna, Helena Edlund, Karthick Vishwanathan, Shringi Sharma, Huan Liu, Joseph Ware, Helen Tomkinson
Publikováno v:
British journal of clinical pharmacology. 88(2)
This analysis aimed to describe the pharmacokinetics (PK) of acalabrutinib and its active metabolite, ACP-5862. A total of 8935 acalabrutinib samples from 712 subjects and 2394 ACP-5862 samples from 304 subjects from 12 clinical studies in patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54a3b6d225983a07fccf2c6c067452e
https://pubmed.ncbi.nlm.nih.gov/34265100
https://pubmed.ncbi.nlm.nih.gov/34265100
Autor:
James Mann, Nataliya Kuptsova-Clarkson, Holly L MacArthur, Shringi Sharma, David Ramies, Michal Majewski, Anouk de Jong, Veerendra Munugalavadla, Harini Burri, Helen Tomkinson, Xavier Pepin, Lianqing Zheng, Joseph Ware, Ting Yu, Louise Sheridan
Publikováno v:
Blood. 138:4365-4365
Introduction: Acalabrutinib (Calquence ®), a selective Bruton tyrosine kinase (BTK) inhibitor, is approved for the treatment of mantle cell lymphoma (relapsed/refractory) and chronic lymphocytic leukemia. Patients with hematologic malignancies may r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e37847b29d3c57c97b09f32c0a8de011
https://doi.org/10.1182/blood-2021-146610
https://doi.org/10.1182/blood-2021-146610
Autor:
Andrew A. Mortlock, Connie Larsson, Kosinsky Yuri, Gabriel Helmlinger, Lulu Chu, Karthick Vishwanathan, Millie Shah, Andrew Bloecher, Hannah Dry, Kirill Peskov, Brandon Willis, Joseph Ware
Publikováno v:
Blood. 134:5304-5304
Introduction The activated B cell like (ABC) subtype of DLBCL has a 40% cure rate with currently available therapies [1] - worse than the rate for germinal center B-cell like (GCB) DLBCL, which highlights the need for ABC subtype-specific treatment s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93040736eb7552e6ae73c700577163de
https://doi.org/10.1182/blood-2019-130879
https://doi.org/10.1182/blood-2019-130879
Autor:
Young G, Shin, Steve A, Jones, Stan C, Murakami, Nageshwar, Budha, Joseph, Ware, Harvey, Wong, Michael H, Buonarati, Brian, Dean, Cornelis E C A, Hop
Publikováno v:
Biomedical chromatography : BMC. 27(1)
A liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the determination of GDC-0152 in human plasma to support clinical development. The method consisted of a solid-phase extraction for sample preparation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e67840c198f960b37b05e72e1cfe29fc
https://pubmed.ncbi.nlm.nih.gov/22623056
https://pubmed.ncbi.nlm.nih.gov/22623056