Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Joseph W. Schafer"'
Autor:
Devlina Chakravarty, Joseph W. Schafer, Ethan A. Chen, Joseph F. Thole, Leslie A. Ronish, Myeongsang Lee, Lauren L. Porter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Recent work suggests that AlphaFold (AF)–a deep learning-based model that can accurately infer protein structure from sequence–may discern important features of folded protein energy landscapes, defined by the diversity and frequency of
Externí odkaz:
https://doaj.org/article/7b3f673b8890490baeb8156a9bc56344
Autor:
Joseph W. Schafer, Lauren L. Porter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Although most globular proteins fold into a single stable structure, an increasing number have been shown to remodel their secondary and tertiary structures in response to cellular stimuli. State-of-the-art algorithms predict that these fold
Externí odkaz:
https://doaj.org/article/053ef8ad0dc9465398399847ee92fb80
Publikováno v:
Protein Science. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdcb8b242b2f7d91dd30baea8ef1f400
https://doi.org/10.1002/pro.4596
https://doi.org/10.1002/pro.4596
Publikováno v:
ACS Catal
Creating efficient and stable enzymes for catalysis in pharmaceutical and industrial laboratories is an important research goal. Arnold et al. used directed evolution to engineer a natural tryptophan synthase to create a mutant that is operable under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16673331672987022577d6de53098a02
https://pubmed.ncbi.nlm.nih.gov/35719741
https://pubmed.ncbi.nlm.nih.gov/35719741
Autor:
Joseph W. Schafer, Steven D. Schwartz
Publikováno v:
ACS Catal
Protein engineering is a growing field with a variety of experimental techniques available for altering protein function. However, creating an enzyme de novo is still in its infancy, so far yielding enzymes of modest catalytic efficiency. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edf291e244c42b44f9382eb4e98452c
https://doi.org/10.1021/acscatal.0c01618
https://doi.org/10.1021/acscatal.0c01618
Autor:
Lauren L. Porter, Joseph W. Schafer, Devlina Chakravarty, Allen Kim, Swechha Rimal, Loren Looger, Ananya K. Majumdar, Mary Starich, Marie-Paule Strub
Publikováno v:
Biophysical Journal. 122:470a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f82b10aed7ca7aad624b8d9dfe3b0b9d
https://doi.org/10.1016/j.bpj.2022.11.2520
https://doi.org/10.1016/j.bpj.2022.11.2520
Publikováno v:
Biophysical Journal. 118:138a-139a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71591923dc56941d506a447f86004b1b
https://doi.org/10.1016/j.bpj.2019.11.882
https://doi.org/10.1016/j.bpj.2019.11.882
Publikováno v:
J Am Chem Soc
The design of artificial enzymes is an emerging field of research. Although progress has been made, the catalytic proficiency of many designed enzymes is low compared to natural enzymes. Nevertheless, recently Hilvert et al. ( Nat. Chem. 2017, 9, 50-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25822121ecb878b0e0f3f1b04e975e2a
https://pubmed.ncbi.nlm.nih.gov/31199129
https://pubmed.ncbi.nlm.nih.gov/31199129
Publikováno v:
Biophysical Journal. 116:432a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97701c1fa85adbcdff5664c57fec052c
https://doi.org/10.1016/j.bpj.2018.11.2325
https://doi.org/10.1016/j.bpj.2018.11.2325