Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Joseph W. Parks"'
Telomeres are essential chromosome end capping structures that safeguard the genome from dangerous DNA processing events. DNA strand invasion occurs during vital transactions at telomeres, including telomere length maintenance by the alternative leng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1435e9c2beb3463c438c35fbc64a7ad0
https://doi.org/10.1101/2021.06.22.449520
https://doi.org/10.1101/2021.06.22.449520
Single-molecule FRET-Rosetta reveals RNA structural rearrangements during human telomerase catalysis
Publikováno v:
RNA. 23:175-188
Maintenance of telomeres by telomerase permits continuous proliferation of rapidly dividing cells, including the majority of human cancers. Despite its direct biomedical significance, the architecture of the human telomerase complex remains unknown.
Autor:
Michael D. Stone, Joseph W. Parks, Rishika Baral, Cheng Lu, Linnea I. Jansson, Jendrik Hentschel, Clive R. Bagshaw, Terren R. Chang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 19
Telomerase reverse transcribes short guanine (G)-rich DNA repeat sequences from its internal RNA template to maintain telomere length. G-rich telomere DNA repeats readily fold into G-quadruplex (GQ) structures in vitro, and the presence of GQ-prone s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137c3c5f1ca2de28b5feb3d5a82ec581
https://escholarship.org/uc/item/9958k99m
https://escholarship.org/uc/item/9958k99m
Autor:
Michael D. Stone, Terren R. Chang, Rishika Baral, Joseph W. Parks, Jendrik Hentschel, Clive R. Bagshaw, Linnea I. Jansson
Telomerase maintains telomere length by reverse transcribing short G-rich DNA repeat sequences from its internal RNA template. G-rich telomere DNA repeats readily fold into G-quadruplex (GQ) structures in vitro, and the presence of GQ-prone sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b85853c005f4d5b6a1c369784ad3914
https://doi.org/10.1101/435545
https://doi.org/10.1101/435545
Autor:
Jean L. Patterson, Joseph W. Parks, Holger Schmidt, Alexandra Stambaugh, G. G. Meena, Aadhar Jain, Aaron R. Hawkins
Publikováno v:
2018 IEEE Photonics Conference (IPC).
Amplification-free and high throughput single nucleic acid detection, with minimal user input, is achieved by integrating optical waveguides with programmable valve array on a single microfluidic platform. Automated preparation and analysis of a dual
Publikováno v:
2018 IEEE Photonics Conference (IPC).
Multi-channel velocimetry for multiplexed particle detection is demonstrated on-chip using a PDMS based optofluidic platform. One liquid-core multimode interference waveguide is used to excite two detection liquid-core channels. Three wavelengths are
Autor:
M. A. Stott, Aaron R. Hawkins, Holger Schmidt, Alexandra Stambaugh, Joseph W. Parks, G. M. Meena
Publikováno v:
2017 IEEE Photonics Conference (IPC).
We report a novel technique for simultaneous detection of nucleic acid and protein biomarkers using multimode interference (MMI) waveguides on an optofluidic chip. Multiplex detection of Zika virus nucleic acids and proteins using two-color multi-spo
Autor:
Joseph W. Parks, Michael D. Stone
Publikováno v:
Annual review of biophysics, vol 46, iss 1
Telomeres are specialized chromatin structures that protect chromosome ends from dangerous processing events. In most tissues, telomeres shorten with each round of cell division, placing a finite limit on cell growth. In rapidly dividing cells, inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae0559bdc2c28694ee7cd41d4f7bdc7
https://europepmc.org/articles/PMC5624789/
https://europepmc.org/articles/PMC5624789/
Publikováno v:
Conference on Lasers and Electro-Optics.
Multi-mode interference waveguides are used to implement simultaneous spectral and spatial multiplex fluorescence analysis in liquid-core waveguide channels. A six-times multiplex identification of single influenza viruses is demonstrated with two ex
Autor:
Joshua W. Parks, Joseph W. Parks, Hong Cai, Thomas Wall, Holger Schmidt, M. A. Stott, Aaron R. Hawkins, Damla Ozcelik
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(42)
Optical waveguides simultaneously transport light at different colors, forming the basis of fiber-optic telecommunication networks that shuttle data in dozens of spectrally separated channels. Here, we reimagine this wavelength division multiplexing