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pro vyhledávání: '"Joseph W. Brewer"'
Autor:
Joseph W. Brewer, Andrew E. Byrd
Publikováno v:
Cells, Vol 1, Iss 4, Pp 738-753 (2012)
Stress in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), a signaling mechanism that allows cellular adaptation to ER stress by engaging pro-adaptive transcription factors and alleviating protein folding demand. One such
Externí odkaz:
https://doaj.org/article/ad9278ff0d31444fb54e8691806a73da
Autor:
Joseph W. Brewer, Suzanne Jackowski
Publikováno v:
Biochemistry Research International, Vol 2012 (2012)
The unfolded protein response (UPR) can coordinate the regulation of gene transcription and protein translation to balance the load of client proteins with the protein folding and degradative capacities of the ER. Increasing evidence also implicates
Externí odkaz:
https://doaj.org/article/600d4470c0924b1aaa898907b6ec7618
Publikováno v:
Cellular Immunology. 310:78-88
In activated B cells, increased production of phosphatidylcholine (PtdCho), the most abundant cellular phospholipid, is handled primarily by the CDP-choline pathway. B cell-specific deletion of CTP:phosphocholine cytidylyltransferase α (CCTα), the
Publikováno v:
The FASEB Journal. 33
Poor nutrition and alcohol intake are leading environmental factors associated with morbidity and mortality worldwide. However, the physiological interactions between poor diet and excessive alcoho...
Autor:
Andrew E. Byrd, Joseph W. Brewer
Publikováno v:
Cells
Cells, Vol 1, Iss 4, Pp 738-753 (2012)
Cells, Vol 1, Iss 4, Pp 738-753 (2012)
Stress in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), a signaling mechanism that allows cellular adaptation to ER stress by engaging pro-adaptive transcription factors and alleviating protein folding demand. One such
Publikováno v:
Molecular Immunology. 51:347-355
B lymphocytes, like all mammalian cells, are equipped with the unfolded protein response (UPR), a complex signaling system allowing for both pro- and mal-adaptive responses to increased demands on the endoplasmic reticulum (ER). The UPR is comprised
Publikováno v:
The Journal of Cell Biology
The PERK pathway influences the scale of XBP1-mediated gene expression and cell fate in response to ER stress via miR-30c-2*.
Stress in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), a multifaceted signaling system
Stress in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), a multifaceted signaling system
Autor:
James F. Collawn, Rafal Bartoszewski, David K. Crossman, Joseph W. Brewer, Niren Kapoor, Sylwia Bartoszewska, Zsuzsa Bebok, Catherine M. Fuller, Andras Rab
Publikováno v:
Journal of Biological Chemistry. 286:41862-41870
To identify endoplasmic reticulum (ER) stress-induced microRNAs (miRNA) that govern ER protein influx during the adaptive phase of unfolded protein response, we performed miRNA microarray profiling and analysis in human airway epithelial cells follow
Publikováno v:
The Journal of Immunology. 200:48.11-48.11
The transcription factor X-box binding protein 1 (XBP1) plays critical roles in the immune system. For example, XBP1 is required for plasma cell development and can disrupt proper function of tumor-associated dendritic cells. A number of post-transcr
Autor:
Matthew W. Frank, Hemamalini Bommiasamy, Suzanne Jackowski, Kyungho Lee, Paolo Fagone, Rungtawan Sriburi, Sasha Meshinchi, Elizabeth Vink, Joseph W. Brewer, Sung Hoon Back, Randal J. Kaufman
Publikováno v:
Journal of Cell Science. 122:1626-1636
A link exists between endoplasmic reticulum (ER) biogenesis and the unfolded protein response (UPR), a complex set of signaling mechanisms triggered by increased demands on the protein folding capacity of the ER. The UPR transcriptional activator X-b