Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Joseph W Zagorski"'
Autor:
Kelly R VanDenBerg, Robert A Freeborn, Sheng Liu, Rebekah C Kennedy, Joseph W Zagorski, Cheryl E Rockwell
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185579 (2017)
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a stress-activated transcription factor that induces a variety of cytoprotective genes. Nrf2 also mediates immunosuppressive effects in multiple inflammatory models. Upon activation, Nrf2 dissocia
Externí odkaz:
https://doaj.org/article/320e1da08ef44a84b825547fc660a33b
Autor:
Joseph W Zagorski, Norbert E Kaminski
Publikováno v:
Toxicological Sciences. 193:115-118
In November of 2021, the European Food Safety Authority (EFSA) released a draft scientific opinion on bisphenol A (BPA) exposure and health outcomes released to the public. EFSA concluded that the most sensitive outcome category to BPA exposure is th
Publikováno v:
Toxicology. 488:153469
Autor:
Jacob Bauss, Michele Morris, Rama Shankar, Rosemary Olivero, Leah N. Buck, Cynthia L. Stenger, David Hinds, Joshua Mills, Alexandra Eby, Joseph W. Zagorski, Caitlin Smith, Sara Cline, Nicholas L. Hartog, Bin Chen, John Huss, Joseph A. Carcillo, Surender Rajasekaran, Caleb P. Bupp, Jeremy W. Prokop
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
In the age of genomics, public understanding of complex scientific knowledge is critical. To combat reductionistic views, it is necessary to generate and organize educational material and data that keep pace with advances in genomics. The view that C
Autor:
Robert A. Freeborn, Jenna K. Bursley, Joseph W. Zagorski, Cheryl E Rockwell, Joshua R. Edwards, Rebekah C. Kennedy, Alexandra E Turley
Publikováno v:
Toxicology Research. 8:227-237
Cadmium is a toxic metal and common environmental contaminant. Chronic cadmium exposure results in kidney, bone, reproductive, and immune toxicity as well as cancer. Cadmium induces splenomegaly and affects the adaptive immune system, but specific ef
Autor:
Kathleen A. Gallo, Charuta C. Palsuledesai, Thomas S. Dexheimer, Richard R. Neubig, Sean A. Misek, Kathryn M. Appleton, Maja K. Blake, Joseph W. Zagorski
Publikováno v:
Cancers
Cancers, Vol 13, Iss 2012, p 2012 (2021)
Volume 13
Issue 9
Cancers, Vol 13, Iss 2012, p 2012 (2021)
Volume 13
Issue 9
The Ras/MEK/ERK pathway has been the primary focus of targeted therapies in melanoma
it is aberrantly activated in almost 80% of human cutaneous melanomas (≈50% BRAFV600 mutations and ≈30% NRAS mutations). While drugs targeting the MAPK path
it is aberrantly activated in almost 80% of human cutaneous melanomas (≈50% BRAFV600 mutations and ≈30% NRAS mutations). While drugs targeting the MAPK path
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 361:259-267
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a stress-activated transcription factor activated by stimuli such as electrophilic compounds and other reactive xenobiotics. Previously, we have shown that the commonly used food additive and Nrf2
Autor:
Kathryn M. Appleton, Joseph W. Zagorski, Maja K. Blake, Charuta C. Palsuledesai, Richard R. Neubig, Thomas S. Dexheimer, Sean A. Misek
The Ras/MEK/ERK pathway has been the primary focus of targeted therapies in melanoma; it is aberrantly activated in almost 80% of human cutaneous melanomas (∼50% BRAFV600 mutations and ∼30% NRAS mutations). While targeted therapies have yielded s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bf9dbeea41b75c14b54833e18f18fb
Autor:
Sheng Liu, Elizabeth M. Gardner, Robert A. Freeborn, Alexandra E Turley, Joseph W. Zagorski, Cheryl E Rockwell, Allison Boss
OBJECTIVES: We examined the effects of the food preservative, tert-Butylhydroquinone (tBHQ), on natural killer (NK) cells when infected with influenza in C57Bl/6 mice. Previously, we found tBHQ to negatively impact splenic NK cell effector function i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66c31ac33645b236d47f61f8ad640d3
https://europepmc.org/articles/PMC6574211/
https://europepmc.org/articles/PMC6574211/
Autor:
Alexandra E Turley, Allison Boss, Sheng Liu, Cheryl E Rockwell, Elizabeth M. Gardner, Robert A. Freeborn, Joseph W. Zagorski, Yining Jin, Rebekah C. Kennedy, Stephanie A. Brocke
Publikováno v:
The FASEB Journal. 33
Influenza virus infections have been a persistent threat to society, causing up to 650,000 respiratory deaths annually world-wide. The United States alone suffered 80,000 influenza-related deaths d...