Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Joseph W Thornton"'
Publikováno v:
eLife, Vol 12 (2024)
A protein’s genetic architecture – the set of causal rules by which its sequence produces its functions – also determines its possible evolutionary trajectories. Prior research has proposed that the genetic architecture of proteins is very comp
Externí odkaz:
https://doaj.org/article/322993c1c1ed478d814735598c95cd5f
Publikováno v:
eLife, Vol 10 (2021)
The roles of chance, contingency, and necessity in evolution are unresolved because they have never been assessed in a single system or on timescales relevant to historical evolution. We combined ancestral protein reconstruction and a new continuous
Externí odkaz:
https://doaj.org/article/cbd4a960942f48688a4bc4cbdf8ec653
Autor:
Qinwen Liu, Pinar Onal, Rhea R Datta, Julia M Rogers, Urs Schmidt-Ott, Martha L Bulyk, Stephen Small, Joseph W Thornton
Publikováno v:
eLife, Vol 7 (2018)
The ancient mechanisms that caused developmental gene regulatory networks to diversify among distantly related taxa are not well understood. Here we use ancestral protein reconstruction, biochemical experiments, and developmental assays of transgenic
Externí odkaz:
https://doaj.org/article/cd4ba06be696424196a71f5fdaa8b314
Autor:
Douglas P Anderson, Dustin S Whitney, Victor Hanson-Smith, Arielle Woznica, William Campodonico-Burnett, Brian F Volkman, Nicole King, Joseph W Thornton, Kenneth E Prehoda
Publikováno v:
eLife, Vol 5 (2016)
Externí odkaz:
https://doaj.org/article/d163b99aabce4d4e869921863c92c4b2
Autor:
Douglas P Anderson, Dustin S Whitney, Victor Hanson-Smith, Arielle Woznica, William Campodonico-Burnett, Brian F Volkman, Nicole King, Joseph W Thornton, Kenneth E Prehoda
Publikováno v:
eLife, Vol 5 (2016)
To form and maintain organized tissues, multicellular organisms orient their mitotic spindles relative to neighboring cells. A molecular complex scaffolded by the GK protein-interaction domain (GKPID) mediates spindle orientation in diverse animal ta
Externí odkaz:
https://doaj.org/article/7a65c4bcff1e44fe918790d2f5a1f597
Publikováno v:
eLife, Vol 4 (2015)
Complexes of specifically interacting molecules, such as transcription factor proteins (TFs) and the DNA response elements (REs) they recognize, control most biological processes, but little is known concerning the functional and evolutionary effects
Externí odkaz:
https://doaj.org/article/5189ae9b95f047f5a8cd1a86ea03eebf
Autor:
Kathryn M Hart, Michael J Harms, Bryan H Schmidt, Carolyn Elya, Joseph W Thornton, Susan Marqusee
Publikováno v:
PLoS Biology, Vol 12, Iss 11, p e1001994 (2014)
Proteins from thermophiles are generally more thermostable than their mesophilic homologs, but little is known about the evolutionary process driving these differences. Here we attempt to understand how the diverse thermostabilities of bacterial ribo
Externí odkaz:
https://doaj.org/article/62689c0666cd47c69cc017d59a7320ae
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004058 (2014)
An important goal in molecular evolution is to understand the genetic and physical mechanisms by which protein functions evolve and, in turn, to characterize how a protein's physical architecture influences its evolution. Here we dissect the mechanis
Externí odkaz:
https://doaj.org/article/2b2b4e4d770542f48100cb087436e833
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003072 (2012)
Most proteins are regulated by physical interactions with other molecules; some are highly specific, but others interact with many partners. Despite much speculation, we know little about how and why specificity/promiscuity evolves in natural protein
Externí odkaz:
https://doaj.org/article/3bda7cf931ed494c80d31fc15a0e4b4a
Publikováno v:
PLoS Genetics, Vol 7, Iss 6, p e1002117 (2011)
Understanding the genetic, structural, and biophysical mechanisms that caused protein functions to evolve is a central goal of molecular evolutionary studies. Ancestral sequence reconstruction (ASR) offers an experimental approach to these questions.
Externí odkaz:
https://doaj.org/article/534ee399467d44e286c4800c9aec5b85