Výsledky vyhledávání - "Joseph V. Manetta"

Model peptides to study the effects of P2and P3substitutions in statine-containing HIV proteinase inhibitors

Autor: Joseph V. Manetta, Eddie L. Angleton, Robert B. Hermann, Kwan Y. Hui, Theresa Gygi

Publikováno v: FEBS Letters. 327:355-360

Through a series of synthetic model peptides, we have examined the structural requirements of the P2 and P3 residues in statine-based HIV protease (PR) inhibitors. Results agree with the general observations that, the more bulky the P3 aromatic hydro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf80a0d6e5180365db2426c3c3652901
https://doi.org/10.1016/0014-5793(93)81020-z

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A rational approach in the search for potent inhibitors against HIV proteinase

Autor: Theresa Gygi, William M. Shannon, Bonnie J. Bowdon, Kathy A. Keith, Kwan Y. Hui, Mei-Huei T. Lai, Joseph V. Manetta

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 5(11)

Synthetic peptides described as dog renin inhibitors were found to effectively inhibit the aspartyl protease of human immunodeficiency virus (HIV). The selection of oligopeptides for the HIV protease inhibition study was based on 1) the current strat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32595667ac4416e8ba94ecce5914db77
https://pubmed.ncbi.nlm.nih.gov/1868985

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