Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Joseph V Raimondo"'
Autor:
Richard J Burman, Lauren M Watson, Danielle C Smith, Joseph V Raimondo, Robea Ballo, Janine Scholefield, Sally A Cowley, Matthew J A Wood, Susan H Kidson, Leslie J Greenberg
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247434 (2021)
Spinocerebellar ataxia type 7 (SCA7) is an inherited neurodegenerative disease caused by a polyglutamine repeat expansion in the ATXN7 gene. Patients with this disease suffer from a degeneration of their cerebellar Purkinje neurons and retinal photor
Externí odkaz:
https://doaj.org/article/d17f542b1879484485ae79adc792653e
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 5, p e1007932 (2020)
Fast synaptic inhibition is a critical determinant of neuronal output, with subcellular targeting of synaptic inhibition able to exert different transformations of the neuronal input-output function. At the receptor level, synaptic inhibition is prim
Externí odkaz:
https://doaj.org/article/871e7a2591dd4925943e7d1d81e4dcd2
Autor:
Christopher B Currin, Phumlani N Khoza, Alexander D Antrobus, Peter E Latham, Tim P Vogels, Joseph V Raimondo
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 7, p e1007049 (2019)
Externí odkaz:
https://doaj.org/article/9d5da0b32bd74b11beb155d5904765f3
Autor:
Joshua S. Selfe, Teresa J. S. Steyn, Eran F. Shorer, Richard J. Burman, Kira M. Düsterwald, Ariel Z. Kraitzick, Ahmed S. Abdelfattah, Eric R. Schreiter, Sarah E. Newey, Colin J. Akerman, Joseph V. Raimondo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Ionic driving forces provide the net electromotive force for ion movement across receptors, channels, and transporters, and are a fundamental property of all cells. In the nervous system, fast synaptic inhibition is mediated by chloride perm
Externí odkaz:
https://doaj.org/article/c0646bb3d3a84e5dae514f6b764b6a3a
Autor:
Kira M Düsterwald, Christopher B Currin, Richard J Burman, Colin J Akerman, Alan R Kay, Joseph V Raimondo
Publikováno v:
eLife, Vol 7 (2018)
Fast synaptic inhibition in the nervous system depends on the transmembrane flux of Cl- ions based on the neuronal Cl- driving force. Established theories regarding the determinants of Cl- driving force have recently been questioned. Here, we present
Externí odkaz:
https://doaj.org/article/e9a813f7c04348fd9fe281c9429697d1
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106363- (2023)
Summary: Intracellular chloride and pH play fundamental roles in determining a neuron’s synaptic inhibition and excitability. Yet it has been difficult to measure changes in these ions during periods of heightened network activity, such as occur in
Externí odkaz:
https://doaj.org/article/9025d1633a5b469286b62a8748f91148
Autor:
Neela K. Codadu, Robert T. Graham, Richard J. Burman, R. Thomas Jackson‐Taylor, Joseph V. Raimondo, Andrew J. Trevelyan, R. Ryley Parrish
Publikováno v:
Physiological Reports, Vol 7, Iss 19, Pp n/a-n/a (2019)
Abstract Much debate exists about how the brain transitions into an epileptic seizure. One source of confusion is that there are likely to be critical differences between experimental seizure models. To address this, we have compared the evolving act
Externí odkaz:
https://doaj.org/article/4e551e9cdeed4faaadcabc914c99a425
Fast synaptic inhibition determines neuronal response properties in the mammalian brain and is mediated by chloride-permeable ionotropic GABA-A receptors (GABAARs). Despite their fundamental role, it is still not known how GABAARs signal in the intac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff49d9bd5f63ec87d33d8306a8c5ef04
https://doi.org/10.1101/2023.03.01.530641
https://doi.org/10.1101/2023.03.01.530641
Autor:
Amalia N. Awala, Maahir Kauchali, Anja de Lange, Emily Ruth Higgitt, Tshepiso Mbangiwa, Joseph V. Raimondo, Rachael Dangarembizi
Publikováno v:
Methods in Molecular Biology ISBN: 9781071631980
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de89dfcc7872a79521bc60e0fe7db29e
https://doi.org/10.1007/978-1-0716-3199-7_3
https://doi.org/10.1007/978-1-0716-3199-7_3
Autor:
Richard J, Burman, Richard E, Rosch, Jo M, Wilmshurst, Arjune, Sen, Georgia, Ramantani, Colin J, Akerman, Joseph V, Raimondo
Publikováno v:
Nature reviews. Neurology. 18(7)
Status epilepticus is a life-threatening neurological emergency that affects both adults and children. Approximately 36% of episodes of status epilepticus do not respond to the current preferred first-line treatment, benzodiazepines. The proportion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aa0fd7ab2134b890d92aed2fcba6664e
https://pubmed.ncbi.nlm.nih.gov/35585227
https://pubmed.ncbi.nlm.nih.gov/35585227