Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Joseph V Haas"'
Autor:
Melissa A Bellinger, James S Bean, Melissa A Rader, Kathleen M Heinz-Taheny, Jairo S Nunes, Joseph V Haas, Laura F Michael, Mark D Rekhter
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93297 (2014)
BACKGROUND: Acute kidney injury (AKI) is a syndrome characterized by the rapid loss of the kidney excretory function and is strongly associated with increased early and long-term patient morbidity and mortality. Early diagnosis of AKI is challenging;
Externí odkaz:
https://doaj.org/article/ed5393dd682c48c7a0d43188c1bf53c0
Autor:
Charmaine Y Pietersen, Fokko J Bosker, Janine Doorduin, Minke E Jongsma, Folkert Postema, Joseph V Haas, Michael P Johnson, Tineke Koch, Tony Vladusich, Johan A den Boer
Publikováno v:
PLoS ONE, Vol 2, Iss 12, p e1360 (2007)
Schizophrenia is often associated with emotional blunting--the diminished ability to respond to emotionally salient stimuli--particularly those stimuli representative of negative emotional states, such as fear. This disturbance may stem from dysfunct
Externí odkaz:
https://doaj.org/article/6b7498e791fb4f35b096ae79bbd8a290
Autor:
Xiaojun Wang, Xiaohong Yu, Kostas Gavardinas, Asim Dey, Hong Y. Zhang, Gina Porter, Leah Porras, Lan Yu, Haihong Guo, Charles A. Reidy, Joseph V. Haas, Yanping Xu, Mark C. Kowala, Prabhakar K. Jadhav, John R. Wetterau
Publikováno v:
PLoS ONE, Vol 19, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/cf754e359bf0477f99695de1e49dc0e7
Autor:
Guanlin Li, Grace Lai-Hung Wong, Terry Cheuk-Fung Yip, Qingxiong Tan, Huapeng Lin, Jonathan Matthew Wilson, Lenden M Bowsman, Joseph V Haas, Anthony Wing-Hung Chan, Howard Ho-Wai Leung, Xinrong Zhang, Yee-Kit Tse, Sally She-Ting Shu, Angel Mei-Ling Chim, Henry Lik-Yuen Chan, Pong Chi Yuen, Vincent Wai-Sun Wong, Kevin L. Duffin, Yu Chen
Background: A number of protein biomarkers have been proposed for the assessment of non-alcoholic fatty liver disease (NAFLD), but few have been externally validated and directly compared. The aim of this study was to compare the diagnostic accuracie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd9b3fef1e7201d42071066eede5d386
https://doi.org/10.21203/rs.3.rs-2118271/v1
https://doi.org/10.21203/rs.3.rs-2118271/v1
Autor:
Xiaojun Wang, Yanping Xu, Xiaohong Yu, Asim Dey, Hong Y. Zhang, Charity M. Zink, Derek Wodka, Gina Porter, William F. Matter, Leah Porras, Charles A. Reidy, Jeffrey A. Peterson, Brian E. Mattioni, Joseph V. Haas, Mark C. Kowala, John R. Wetterau
Publikováno v:
Pharmacology researchperspectives. 10(2)
An excess phosphate burden in renal disease has pathological consequences for bone, kidney, and heart. Therapies to decrease intestinal phosphate absorption have been used to address the problem, but with limited success. Here, we describe the in viv
Autor:
Harvey D. White, Paul W. Armstrong, E. Magnus Ohman, Lenden M. Bowsman, Mark Y. Chan, Svati H. Shah, Simon G. Gregory, Kevin L. Duffin, Joseph V. Haas, Keith A.A. Fox, Megan L. Neely, Elizabeth Grass, Matthew T. Roe, Lydia Coulter Kwee
Publikováno v:
Physiological Genomics
The genomic regulatory networks underlying the pathogenesis of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) are incompletely understood. As intermediate traits, protein biomarkers report on underlying disease severity and prognosis in
Autor:
Christopher P. Austin, Rajarshi Guha, Madhu Lal-Nag, Bart Trawick, Michelle R. Arkin, Timothy L. Foley, Philip W. Iversen, Jonathan B. Baell, Thomas D.Y. Chung, Zhuyin Li, Eric W. Sayers, Neely Gal-Edd, James McGee, Owen B. McManus, Hanguan Liu, Nathan P. Coussens, Xin Xu, Viswanath Devanaryan, Marilu A. Hoeppner, Matthew D. Hall, Bruce E. Bejcek, Vance Lemmon, Kyle R. Brimacombe, Jeffrey R. Weidner, Jayme L. Dahlin, Andrew D. Napper, Steven D. Kahl, Anton Simeonov, James Inglese, Robert Pacifici, G. Sitta Sittampalam, Lisa Minor, William W. Chin, Abigail Grossman, Julie McVey, Sam Michael, Douglas S. Auld, Stacy Lathrop, Menghang Xia, Terry L. Riss, Mary Jo Wildey, Marcie A. Glicksman, Joseph V. Haas, Stephen C. Kales, O. Joseph Trask
Publikováno v:
Clinical and Translational Science. 11:461-470
The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a "tes
Autor:
Frank C. Brosius, Ravindra L. Mehta, Fabio P. Nunes, William L. Macias, Katherine R. Tuttle, Sharon G. Adler, Jonathan Janes, Kevin L. Duffin, James A. Tumlin, Maria E Silk, Joseph V. Haas, Jiajun Liu, Matthias Kretzler, Yoshiya Tanaka, Masakazu Haneda, Tracy Cardillo
Publikováno v:
Nephrology Dialysis Transplantation
Background Inflammation signaled by Janus kinases (JAKs) promotes progression of diabetic kidney disease (DKD). Baricitinib is an oral, reversible, selective inhibitor of JAK1 and JAK2. This study tested the efficacy of baricitinib versus placebo on
Autor:
Kenneth Cusi, Srilaxmi Kalavalapalli, Kenneth D. Roth, Paul L. Milligan, Kevin L. Duffin, Qian Yang, Joseph V. Haas, Mark L. Hartman, Fernando Bril, Yu Chen
Publikováno v:
Diabetes. 67
Nonalcoholic fatty liver disease (NAFLD) affects a significant number of patients with T2DM and places them at an increased risk of steatohepatitis (NASH) and cirrhosis. However, it is widely underdiagnosed due to lack of a simple, non-invasive test
Autor:
Anne Reifel Miller, Marialuisa C. Marcelo, Qi Chen, Ruth Belin, Pranab Maiti, Joseph V. Haas, Jared L. Piper, Ellen A. Cannady, Steven D. Kahl, Anjana Patel Lewis, Guemalli R. Cardona, Jason T. Johnson, D. Scott Coffey, Dawn A. Brooks, James Ficorilli, Xiaosu Ma, Sweetana Stephanie Ann, Chafiq Hamdouchi, Yanyun Chen, Edward J. Pratt, Keyue Chen, Richard W. Zink, Kelly L. Wilbur, Keith A. Otto, Mark A. Deeg, Nathan Yumibe, Jayana Pankaj Lineswala, Thomas E Eessalu, Chahrzad Montrose-Rafizadeh
Publikováno v:
Journal of medicinal chemistry. 59(24)
The G protein-coupled receptor 40 (GPR40) also known as free fatty acid receptor 1 (FFAR1) is highly expressed in pancreatic, islet β-cells and responds to endogenous fatty acids, resulting in amplification of insulin secretion only in the presence