Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Joseph Trapani"'
Autor:
Julie A. Spicer, Kristiina M. Huttunen, Jiney Jose, Ivo Dimitrov, Hedieh Akhlaghi, Vivien R. Sutton, Ilia Voskoboinik, Joseph Trapani
Publikováno v:
Journal of Medicinal Chemistry. 65:14305-14325
New drugs that precisely target the immune mechanisms critical for cytotoxic T lymphocyte (CTL) and natural killer (NK) cell driven pathologies are desperately needed. In this perspective, we explore the cytolytic protein perforin as a target for the
Autor:
Alex T. Ritter, Gleb Shtengel, C. Shan Xu, Aubrey Weigel, David P. Hoffman, Melanie Freeman, Nirmala Iyer, Nensi Alivodej, David Ackerman, Ilia Voskoboinik, Joseph Trapani, Harald F. Hess, Ira Mellman
Publikováno v:
Science. 376:377-382
Cytotoxic T lymphocytes (CTLs) and natural killer cells kill virus-infected and tumor cells through the polarized release of perforin and granzymes. Perforin is a pore-forming toxin that creates a lesion in the plasma membrane of the target cell thro
Autor:
Wenxin Hu, Amit Kumar, Shijiao Qi, Teresa Sadras, Joshua Casan, David Ma, Lauren Brown, Michelle Haber, Ilia Voskoboinik, Joseph Trapani, Paul Ekert, Mohamed Fareh
Precision oncology programs can rapidly identify oncogenic gene fusions in individual patients1–3. However, despite their established oncogenic status, the vast majority of gene fusions remain ‘undruggable’ due to the lack of specific inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a805a044cfe3d6695597cf87e996cca
https://doi.org/10.1101/2022.06.22.497105
https://doi.org/10.1101/2022.06.22.497105
Autor:
Wenxin Hu, Wei Zhao, Amit Kumar, Gurjeet Jagjeet Singh, Shijiao Qi, Josh Casan, Carolyn Shembery, Danielle Fong, Jennifer M. Zerbato, Jori Symons, Rajeev Rudraraju, Damian Purcell, Michelle Haber, Ilia Voskoboinik, Paul G. Ekert, Sharon Lewin, Joseph Trapani, Mohamed Fareh
Publikováno v:
Pathology
Autor:
Joseph Trapani
Publikováno v:
Encyclopedia of Immunology ISBN: 9780122267659
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a11d1c38c2a583700d52502be25b60fa
https://doi.org/10.1006/rwei.1999.0266
https://doi.org/10.1006/rwei.1999.0266
Autor:
Paul Neeson, David Ritchie, Amit Khot, Stefan Peinert, Tsin Tai, Dirk Honemann, Peter Gambell, David Westerman, Jennifer Westwood, Andrew Scott, Lucy Kravets, Michael Dickinson, Joseph Trapani, Mark Smyth, Phillip Darcy, Michael Kershaw, H. Prince
Publikováno v:
The Journal of Immunology. 190:177.10-177.10
Second generation chimeric antigen receptor (CAR) T cells were used to treat patients with acute myeloid leukemia (AML) in a phase I clinical study. Autologous T cells were genetically modified to express a CAR which re-directed T cell effector funct