Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Joseph Torchia"'
Autor:
Haider M. Hassan, Oladapo Onabote, Majdina Isovic, Daniel T. Passos, Frederick A. Dick, Joseph Torchia
Publikováno v:
Cancers, Vol 14, Iss 24, p 6191 (2022)
The Farnesoid X Receptor (FXR) belongs to the nuclear receptor superfamily and is an essential bile acid (BA) receptor that regulates the expression of genes involved in the metabolism of BAs. FXR protects the liver from BA overload, which is a major
Externí odkaz:
https://doaj.org/article/aa30c770a5ae41d7a45b9f189dc89595
Publikováno v:
Cancers, Vol 14, Iss 3, p 765 (2022)
DNA methylation is an essential covalent modification that is required for growth and development. Once considered to be a relatively stable epigenetic mark, many studies have established that DNA methylation is dynamic. The 5-methylcytosine (5-mC) m
Externí odkaz:
https://doaj.org/article/67f1fe8db8af4a35b70f4705328e227d
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 4 (2020)
In a recent publication, we demonstrated that conditional deletion of the gene encoding thymine DNA glycosylase (TDG) leads to a late onset of hepatocellular carcinoma (HCC). TDG loss causes disruption in active DNA demethylation in the liver and dys
Externí odkaz:
https://doaj.org/article/493b13ea6e5e40bcace86ea9279e097e
Autor:
Haider M. Hassan, Majdina Isovic, Bart Kolendowski, Natasha Bauer-Maison, Oladapo Onabote, Matthew Cecchini, Aaron Haig, Saman Maleki Vareki, T. Michael Underhill, Joseph Torchia
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: Thymine DNA glycosylase (TDG) is a nuclear receptor coactivator that plays an essential role in the maintenance of epigenetic stability in cells. Here, we demonstrate that the conditional deletion of TDG in adult mice results in a male-predo
Externí odkaz:
https://doaj.org/article/1c7f0c81c5be4026bcbfcb150146cc95
Autor:
Bart Kolendowski, Haider Hassan, Milica Krstic, Majdina Isovic, Gobi Thillainadesan, Ann F. Chambers, Alan B. Tuck, Joseph Torchia
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-19 (2018)
Abstract Background The estrogen receptor (ER) is a ligand-dependant transcription factor expressed in many breast cancers and is the target of many endocrine-based cancer therapies. Genome-wide studies have shown that the ER binds to gene-specific e
Externí odkaz:
https://doaj.org/article/0c534c020e9b47d59484461438530b5e
Autor:
Haider M. Hassan, Bart Kolendowski, Majdina Isovic, Kerstin Bose, Helen J. Dranse, Arthur V. Sampaio, T. Michael Underhill, Joseph Torchia
Publikováno v:
Cell Reports, Vol 19, Iss 8, Pp 1685-1697 (2017)
Retinoic acid (RA) plays important roles in development, growth, and homeostasis through regulation of the nuclear receptors for RA (RARs). Herein, we identify Hypermethylated in Cancer 1 (Hic1) as an RA-inducible gene. HIC1 encodes a tumor suppresso
Externí odkaz:
https://doaj.org/article/6e03681522a548649af0972e5eb6f88e
Autor:
Milica Krstic, Alan B. Tuck, Pieter H. Anborgh, Ann F. Chambers, Haider M. Hassan, Bart Kolendowski, Joseph Torchia, Carl O. Postenka, M. Nicole Hague
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
TBX3 is a member of the highly conserved family of T-box transcription factors involved in embryogenesis, organogenesis and tumor progression. While the functional role of TBX3 in tumorigenesis has been widely studied, less is known about the specifi
Autor:
Milica Krstic, Joseph Torchia, Connor D MacMillan, Haider M. Hassan, Karla C. Williams, Joseph Andrews, Ann F. Chambers, Carl O. Postenka, Matthew J. Cecchini, Alan B. Tuck, Bart Kolendowski, Muriel Brackstone, Hon S. Leong
Publikováno v:
Paediatrics Publications
The Journal of Pathology
The Journal of Pathology
The acquisition of cellular invasiveness by breast epithelial cells and subsequent transition from ductal carcinoma in situ (DCIS) to invasive breast cancer is a critical step in breast cancer progression. Little is known about the molecular dynamics
Autor:
Grace E. Lilly, Frederick A. Dick, Pirunthan Perampalam, Vathany Kulasingam, Haider M. Hassan, Daniel Thompsen Passos, Joseph Torchia, Andrea Bozovic, Patti K. Kiser
Publikováno v:
Paediatrics Publications
J Clin Invest
J Clin Invest
DREAM (Dp, Rb-like, E2F, and MuvB) is a transcriptional repressor complex that regulates cell proliferation, and its loss causes neonatal lethality in mice. To investigate DREAM function in adult mice, we used an assembly-defective p107 protein and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17ef4c54d57d4b3cb1143c0013c0a32
https://ir.lib.uwo.ca/context/paedpub/article/2159/viewcontent/JCI140903.v2.pdf
https://ir.lib.uwo.ca/context/paedpub/article/2159/viewcontent/JCI140903.v2.pdf
Autor:
Joseph Torchia, OP
In Plotinus and Augustine on the Mid-Rank of Soul: Navigating Two Worlds, Joseph Torchia, OP, explores the mid-rank of the soul theme in Plotinus and Augustine with a special focus on its metaphysical, epistemological, and moral implications for each