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pro vyhledávání: '"Joseph Toporowski"'
Autor:
Michael P. Trova, Keith D. Barnes, Curt Barford, Travis Benanti, Mark Bielaska, Lori Burry, John M. Lehman, Christine Murphy, Harold O’Grady, Denise Peace, Susan Salamone, Jennifer Smith, Patricia Snider, Joseph Toporowski, Steven Tregay, Alison Wilson, Michael Wyle, Xiaozhang Zheng, Thomas D. Friedrich
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6608-6612
The introduction of an aryl ring onto the 4-position of the C-6 benzyl amino group of the Cdk inhibitor roscovitine (2), maintained the potent Cdk inhibition demonstrated by roscovitine (2) as well as greatly improving the antiproliferative activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b74222a35c5b64e239a7140455c1dba
https://doi.org/10.1016/j.bmcl.2009.10.025
https://doi.org/10.1016/j.bmcl.2009.10.025
