Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Joseph Therrien"'
Autor:
Adrian Tomkinson, Gary Phillips, Jayaraman Chandrasekhar, Nicholas Alexander Till, Leena Patel, Jia Hao, Jennifer Treiberg, Joseph Therrien, Kathleen S. Keegan, Mary E. McGrath, Sedillo Kassandra F, Fatima Arjmand, Yelena Zherebina, Stephane Perreault, David Koditek, Clinton K. Matson, Eve-Irene Lepist
Publikováno v:
ACS Med Chem Lett
[Image: see text] A series of PI3Kβ selective inhibitors derived from a novel 4-(1H-benzo[d]imidazol-1-yl)quinoline chemotype has been rationally designed. Crucial to achieving the desired selectivity over the other class I PI3K isoforms, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141717e365da34c534fb82eddbca0b95
https://doi.org/10.1021/acsmedchemlett.0c00095
https://doi.org/10.1021/acsmedchemlett.0c00095
Autor:
Gary Phillips, Leena Patel, Stephane Perreault, Jennifer Treiberg, Nicholas Alexander Till, Eve-Irene Lepist, Armando G. Villaseñor, Mary E. McGrath, David Koditek, Yelena Zherebina, John R. Somoza, Sedillo Kassandra F, Joshua Van Veldhuizen, Joseph Therrien, Ryan Dick, Jayaraman Chandrasekhar
Publikováno v:
Journal of Medicinal Chemistry. 61:6858-6868
Atropisomerism is a type of axial chirality in which enantiomers or diastereoisomers arise due to hindered rotation around a bond axis. In this manuscript, we report a case in which torsional scan studies guided the thoughtful creation of a restricte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003a7f21c3079be9796f9eb37ab9e739
https://doi.org/10.1021/acs.jmedchem.8b00797
https://doi.org/10.1021/acs.jmedchem.8b00797
Autor:
Gary Phillips, Nikolai Novikov, Kamal D. Puri, Mary E. McGrath, Leena Patel, Carmen Ip, Arthur Yeung, Latesh Lad, Kirk L. Stevens, Musong Kim, Eve-Irene Lepist, Armando G. Villaseñor, Jayaraman Chandrasekhar, Joseph Therrien, Joshua Kaplan, Jerry Evarts, John R. Somoza, Aaron C. Haran, David Koditek, Stephane Perreault, Bart H. Steiner, Jennifer Treiberg
Publikováno v:
Journal of Medicinal Chemistry. 59:3532-3548
Inhibition of phosphoinositide 3-kinase δ (PI3Kδ) is an appealing target for several hematological malignancies and inflammatory diseases. Herein, we describe the discovery and optimization of a series of propeller shaped PI3Kδ inhibitors comprisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbe4b5b6b4c34240fb4472508c6868c
https://doi.org/10.1021/acs.jmedchem.6b00213
https://doi.org/10.1021/acs.jmedchem.6b00213
Autor:
Anjen Chenn, Chad M. McCall, Gaia Cantelli, Matthew J. Warner, Lindsey A. Olivere, Brandon Ngo, Hisayuki Yao, Joseph Therrien, Elizabeth M. Jablonski, Stacey Tannheimer, Dorothy A. Sipkins, Sarah M. Ridge, Trevor T. Price
Publikováno v:
Nature
Acute lymphoblastic leukaemia (ALL) has a marked propensity to metastasize to the central nervous system (CNS). In contrast to brain metastases from solid tumours, metastases of ALL seldom involve the parenchyma but are isolated to the leptomeninges,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0b96430be0801c116df2a738fa14d3
https://europepmc.org/articles/PMC10257142/
https://europepmc.org/articles/PMC10257142/
Autor:
Jerry Evarts, Gary Phillips, Joshua Kaplan, David Koditek, Kathleen S. Keegan, Adam Kashishian, Zhi-Hua Cui, Joseph Therrien, Jennifer Treiberg, Bart Phillips, Latesh Lad, Eve-Irene Lepist, Jayaraman Chandrasekhar, Leena Patel, Anella Yahiaoui, Stephane Perreault, Jia Hao, Mary E. McGrath, Thomas Kenney
Publikováno v:
Journal of medicinal chemistry. 60(4)
Phosphoinositide 3-kinase (PI3K) β signaling is required to sustain cancer cell growth in which the tumor suppressor phosphatase and tensin homolog (PTEN) has been deactivated. This manuscript describes the discovery, optimization, and in vivo evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a2121eb475207997996dbaba211945
https://pubmed.ncbi.nlm.nih.gov/28106991
https://pubmed.ncbi.nlm.nih.gov/28106991
Autor:
Kamal D. Puri, Carmen Ip, Adam Kashishian, Gary Phillips, Sandy Koppenol, Musong Kim, Jennifer Treiberg, Armando G. Villaseñor, Jayaraman Chandrasekhar, Stephane Perreault, Kristen Forseth, Leena Patel, Mary E. McGrath, Bart H. Steiner, Joseph Therrien, John R. Somoza, Aaron C. Haran, David Koditek, Latesh Lad, Eve-Irene Lepist, Jerry Evarts
Publikováno v:
Journal of medicinal chemistry. 59(19)
Aberrant signaling of phosphoinositide 3-kinase δ (PI3Kδ) has been implicated in numerous pathologies including hematological malignancies and rheumatoid arthritis. Described in this manuscript are the discovery, optimization, and in vivo evaluatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8830debbf42314c8fbf74c493372feca
https://pubmed.ncbi.nlm.nih.gov/27660855
https://pubmed.ncbi.nlm.nih.gov/27660855
Autor:
Thomas F. Kenney, Lynn M. Barker, Joseph Therrien, Jennifer L. Sutherland, William R. Baker, David Macleod, Jyoti Velayudhan
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:1529-1538
Elevated levels of mucins present in bronchiectatic airways predispose patients to bacterial infections and reduce the effectiveness of antibiotic therapies by directly inactivating antibiotics. Consequently, new antibiotics that are not inhibited by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ead647a22a5c19ccd3409f40c50da3d
https://doi.org/10.1128/aac.05958-11
https://doi.org/10.1128/aac.05958-11
Autor:
Xiao Shang, Lonnie A. Robarge, Martin Dimitroff, Shaopei Cai, Joseph Therrien, David Ryckman, Malcolm Reider, Tracey Mckennon
Publikováno v:
Organic Process Research & Development. 8:353-359
Starting from a known linear route and a proposed convergent route, we have successfully developed a new hybrid convergent route to MIV-150 that takes advantage of the robust chemistry for the preparation of a fluoroketal and the stereospecific Negis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f6f770741b695f0679c13df1c153a5b
https://doi.org/10.1021/op0341871
https://doi.org/10.1021/op0341871
Autor:
J.D. Brown, Robert Joseph Therrien, W. Nagy, R. Borges, Kevin J. Linthicum, Thomas Gehrke, P. Rajagopal, Edwin L. Piner, Sameer Singhal, Jerry W. Johnson, John C. Roberts, Andrei Vescan
Publikováno v:
physica status solidi (c). :52-56
GaN grown on Si is currently the only pathway towards high volume manufacturing of GaN based RF devices. In this paper we present the technological status of GaN grown on 100 mm Si substrates. Optimised growth, accounting for the lattice and thermal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdec78b17bd7d5c5d72671b3ac1763a0
https://doi.org/10.1002/pssc.200390106
https://doi.org/10.1002/pssc.200390106
Autor:
Robert Joseph Therrien, Sameer Singhal, Ric Borges, Andrei Vescan, Edwin L. Piner, J.D. Brown
Publikováno v:
Solid-State Electronics. 46:1535-1539
The group III-nitride material system has been demonstrated by many groups to produce high performance, heterostructure field effect transistors (HFETs). AlGaN/GaN heterostructures yield high two-dimensional electron gas densities with high carrier m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b0019a9a31256ac26296279acbb19e2
https://doi.org/10.1016/s0038-1101(02)00101-6
https://doi.org/10.1016/s0038-1101(02)00101-6