Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Joseph Tamasi"'
Autor:
Jawed A. Siddiqui, Joseph Tamasi, Joshua Johnson, Carole Le Henaff, Nicola C. Partridge, Claudine L. Bitel
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
The bone catabolic actions of parathyroid hormone (PTH) are seen in patients with hyperparathyroidism, or with infusion of PTH in rodents. We have previously shown that the chemokine, monocyte chemoattractant protein-1 (MCP-1), is a mediator of PTH
Autor:
Claudine L. Bitel, Nigel Alexander Morrison, Emi Shimizu, Nicola C. Partridge, Joseph Tamasi, Anatoliy Vasilov, Joshua Johnson, Noah A. Benton
Publikováno v:
Journal of Bone and Mineral Research. 28:1975-1986
Parathyroid hormone (PTH) has a significant role as an anabolic hormone in bone when administered by intermittent injection. Previous microarray studies in our laboratory have shown that the most highly regulated gene, monocyte chemoattractant protei
Publikováno v:
Journal of Dental Research. 91:268-274
Bisphosphonates are therapeutic agents in the treatment of post-menopausal osteoporosis. Although they have been associated with delayed healing in injured tissues, inappropriate femoral fractures, and osteonecrosis of the jaw (ONJ), the pathophysiol
Autor:
Jean H.M. Feyen, Nicola C. Partridge, Emi Shimizu, Nagarajan Selvamurugan, Laura M. Bevelock, Liza-Jane Raggatt, Stephen C. Jefcoat, Foo Y. Liew, Joseph Tamasi, Ling Qin
Publikováno v:
Journal of Biological Chemistry. 283:6790-6798
Interleukin-18 (IL-18) can regulate osteoblast and osteoclast function. We have identified, using cDNA microarray technology, that IL-18 expression is increased in UMR 106-01 rat osteoblastic cells in response to parathyroid hormone (PTH) treatment.
Autor:
Jergen Baumann, William A. Schumacher, Thomas E. Steinbacher, Jean H.M. Feyen, Joseph Tamasi, Yizhi Liu, Eileen Bird, James K. Tamura, Anne B. Stewart, Jeffrey S. Bostwick
Publikováno v:
Thrombosis Research. 120:549-558
Introduction TAFI indirectly reduces the action of tPA on plasminogen. Whether exogenous tPA is necessary for TAFI inhibitor efficacy is unclear. Potato carboxypeptidase inhibitor (PCI), a TAFI inhibitor, has shown variable tPA dependence in rat mode
Autor:
Rodney Kowalewski, Sukyee Kwok, Nicola C. Partridge, Stephen C. Jefcoat, Nagarajan Selvamurugan, Joseph Tamasi
Publikováno v:
Journal of Cellular Biochemistry. 99:545-557
The activator protein-1 (AP-1) and runt domain binding (Runx/RD/Cbfa) sites and their respective binding proteins, c-Fos/c-Jun and Runx2 (Cbfa1), regulate the rat matrix metalloproteinase-13 (MMP-13) promoter in both parathyroid hormone (PTH)-treated
Autor:
Joseph Tamasi, Jean H.M. Feyen, Jacques Y. Roberge, Xiaodong Wang, Yu Dong, Zhaoqing Wang, R. Michael Lawrence, Margaret M. Prack, Dora M. Schnur, Vanessa Dell, Yalei Liu, Rajasree Golla, Michele Agler, James R. Corte, Ramakrishna Seethala, Monique Anthony, Tianan Fang, John K. Dickson
Publikováno v:
Steroids. 69:201-217
The identification of a new series of selective nonsteroidal progesterone receptor (PR) agonists is reported. Using a high-throughput screening assay based on the measurement of transactivation of a mouse mammary tumor virus promoter-driven luciferas
Publikováno v:
Journal of Bone and Mineral Research. 18:1605-1611
To investigate the role of leptin in bone formation, the skeleton of the obese female leptin receptor-deficient Zucker rat was examined using pQCT, μCT, and histomorphometry. A trend toward decreasing structural and bone formation parameters in thes
Autor:
Julie C. Frith, Joseph Tamasi, Thomas Harrity, Michele H. French, Michael J. Rogers, Jean H.M. Feyen, JoAnn Swartz, Timur Gungor, Ada Staal
Publikováno v:
Journal of Bone and Mineral Research. 18:88-96
Statins, which are inhibitors of 3-hydroxy-3-glutaryl-coenzyme A (HMG-CoA) reductase, decrease the hepatic biosynthesis of cholesterol by blocking the mevalonate pathway. Nitrogen-containing bisphosphonate drugs also inhibit the mevalonate pathway, p
Autor:
Ling Qin, Ji Zhu, Xin Lu, Xianrong Zhang, Nicola C. Partridge, Xiaoyan Tian, Barbara E. Kream, Haiyan Chen, Joseph Tamasi, Tang Cheng Lee, David W. Threadgill, Yibin Kang
Publikováno v:
Journal of Bone and Mineral Research
While the epidermal growth factor receptor (EGFR)–mediated signaling pathway has been shown to have vital roles in many developmental and pathologic processes, its functions in the development and homeostasis of the skeletal system has been poorly