Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Joseph T. Rodgers"'
Autor:
Hao Zhou, Lisa Nguyen, Cosimo Arnesano, Yuta Ando, Manmeet Raval, Joseph T. Rodgers, Scott Fraser, Rong Lu, Keyue Shen
Publikováno v:
iScience, Vol 23, Iss 2, Pp - (2020)
Summary: Metabolism is a key regulator of hematopoietic stem cell (HSC) functions. There is a lack of real-time, non-invasive approaches to evaluate metabolism in single HSCs. Using fluorescence lifetime imaging microscopy, we developed a set of meta
Externí odkaz:
https://doaj.org/article/6411ab9c0dc14f859f5fd031273b4366
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 479-486 (2017)
Summary: The activation of quiescent stem cells into the cell cycle is a key step in initiating the process of tissue repair. We recently reported that quiescent stem cells can transition into GAlert, a cellular state in which they have an increased
Externí odkaz:
https://doaj.org/article/1f9ed1c512c7427f836e394673665d32
Autor:
Manmeet H. Raval, Joseph T. Rodgers, A. Chareunsouk, M. Ederer, Rajiv Lochan Tiwari, S. Ahsan
Injury to muscle tissue induces the resident, quiescent, skeletal muscle stem cells (MuSCs) to activate - to exit quiescence and enter the cell cycle. Previous work has shown that MuSC activation is associated with significant metabolic changes, howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc1c81a5a8428380f5e22ae57f3970e4
https://doi.org/10.1101/2020.07.28.225847
https://doi.org/10.1101/2020.07.28.225847
Autor:
Manmeet H. Raval, Pin-Chung Cheng, Nicholas Guardino, Sanjana Ahsan, Hao Zhou, Rajiv Lochan Tiwari, Lu Wang, Andrew Chareunsouk, Maxwell Ederer, Ara B. Hwang, Matt Ellenberger, Rob Pepin, Daniel Raftery, Daniel Promislow, Keyue Shen, Andrew S. Brack, Joseph T. Rodgers
Decline in the skeletal muscle stem cell (MuSC) function is a major contributor to age-associated impairments in muscle regeneration and function. The ability of MuSCs to activate (i.e. exit quiescence, enter the cell cycle, and divide) following inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d131a18ef953be98d7b655f1ee9d7b
Autor:
Scott E. Fraser, Manmeet H. Raval, Rong Lu, Keyue Shen, Joseph T. Rodgers, Cosimo Arnesano, Lisa Nguyen, Hao Zhou, Yuta Ando
Publikováno v:
iScience
iScience, Vol 23, Iss 2, Pp-(2020)
iScience, Vol 23, Iss 2, Pp-(2020)
Summary Metabolism is a key regulator of hematopoietic stem cell (HSC) functions. There is a lack of real-time, non-invasive approaches to evaluate metabolism in single HSCs. Using fluorescence lifetime imaging microscopy, we developed a set of metab
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 479-486 (2017)
Summary: The activation of quiescent stem cells into the cell cycle is a key step in initiating the process of tissue repair. We recently reported that quiescent stem cells can transition into GAlert, a cellular state in which they have an increased
Autor:
Yana Cen, Fengying Gong, Brett P. Monia, John M. Asara, Joseph T. Rodgers, Lin Zhang, Odile D. Peroni, Anthony A. Sauve, Daniel Kraus, Ya Chin Wang, Qin Yang, Thomas Pulinilkunnil, Sanjay Bhanot, Pere Puigserver, Alexander S. Banks, Dong Kong, Eija Pirinen, Leena Alhonen, Barbara B. Kahn
Publikováno v:
Nature. 508:258-262
In obesity and type 2 diabetes, Glut4 glucose transporter expression is decreased selectively in adipocytes1. Adipose-specific knockout or overexpression of Glut4 alters systemic insulin sensitivity2. Here we show, using DNA array analyses, that nico
Publikováno v:
Molecular Cell. 41(4):471-479
Akt mediates important cellular decisions involved in growth, survival, and metabolism. The mechanisms by which Akt is phosphorylated and activated in response to growth factors or insulin have been extensively studied, but the molecular regulatory c
Publikováno v:
Cell Metabolism. 11:23-34
SummaryDynamic regulation of insulin signaling and metabolic gene expression is critical to nutrient homeostasis; dysregulation of these pathways is widely implicated in insulin resistance and other disease states. Though the metabolic effects of ins
Autor:
Rebeccah Riley, Julie K. Andersen, Heinrich Jasper, Monique N. O’Leary, Jason R. Rock, Samantha Haller, Joseph T. Rodgers, Simon Melov, Subir Kapuria, Thomas A. Rando, Katherine H. Schreiber, Brian K. Kennedy, Jianwen Que
Publikováno v:
Cell Stem Cell. 21:806-818.e5
The balance between self-renewal and differentiation ensures long-term maintenance of stem cell (SC) pools in regenerating epithelial tissues. This balance is challenged during periods of high regenerative pressure and is often compromised in aged an