Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Joseph T. Neary"'
Publikováno v:
Journal of Neuroscience Research. 86:3096-3105
Extracellular nucleotides play important trophic roles in development and central nervous system (CNS) injury, but the functions of distinct purinergic receptors and related signaling pathways have not been fully elucidated. In the present study we i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47bda37abae0cb09633f99b5da52b420
https://doi.org/10.1002/jnr.21765
https://doi.org/10.1002/jnr.21765
Autor:
Joseph T. Neary, K.B. Washburn
Publikováno v:
Neuroscience. 142:411-423
Extracellular ATP, released upon tissue damage to the CNS, can evoke reactive astrogliosis. The released ATP activates P2 purinergic receptors associated with the proliferation of normally quiescent astrocytes, although the underlying mechanisms rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47dd503dc55358d6f39860de5e22c2fc
https://doi.org/10.1016/j.neuroscience.2006.06.034
https://doi.org/10.1016/j.neuroscience.2006.06.034
Autor:
Minh D. Tran, Joseph T. Neary
Publikováno v:
Proceedings of the National Academy of Sciences. 103:9321-9326
Thrombospondin (TSP)-1, a multidomain glycoprotein, is secreted from astrocytes and promotes synaptogenesis. However, little is known about the mechanisms regulating its expression and release. In this article, we report that purinergic signaling par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a70b40a72c43e78e1c34ae8bf5572d
https://doi.org/10.1073/pnas.0603146103
https://doi.org/10.1073/pnas.0603146103
Autor:
Joseph T. Neary
Publikováno v:
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life). 57:711-718
Advances in our understanding of the signaling pathways and cellular functions regulated by protein kinase cascades have paved the way to study their role in the response of brain and spinal cord to traumatic injury. Mechanical forces imparted by tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fec5769a06a9aa872af9dc37ee3a56c
https://doi.org/10.1080/15216540500319143
https://doi.org/10.1080/15216540500319143
Publikováno v:
Journal of Neurotrauma. 22:491-500
Protein kinase B/Akt is a key signaling molecule that regulates cell survival, growth, and metabolism, and inhibits apoptosis. Traumatic brain injury (TBI) activates Akt, and Akt has been implicated in neuronal survival after TBI, but little is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7f03119d06b129447baac1f0df1ee5
https://doi.org/10.1089/neu.2005.22.491
https://doi.org/10.1089/neu.2005.22.491
Autor:
Fernando A. González, Gary A. Weisman, Qiongman Kong, Joseph T. Neary, Grace Y. Sun, Cheikh I. Seye, Nataliya E. Chorna, L. Erb, Meifang Wang
Publikováno v:
Molecular Neurobiology. 31:169-184
In the mammalian nervous system, P2 nucleotide receptors mediate neurotransmission, release of proinflammatory cytokines, and reactive astrogliosis. Extracellular nucleotides activate multiple P2 receptors in neurons and glial cells, including G prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3be78ee48b6480624e9da610c3e6a138
https://doi.org/10.1385/mn:31:1-3:169
https://doi.org/10.1385/mn:31:1-3:169
Publikováno v:
Neurochemical Research. 29:2037-2042
In the CNS, extracellular ATP can function as an excitatory neurotransmitter as well as a trophic factor. These short-term and long-term actions are mediated by nucleotide receptors. Extracellular ATP can also act as a co-mitogen in conjunction with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7edfd3e20ad6e6d3d13ac26f2ab4397e
https://doi.org/10.1007/s11064-004-6876-y
https://doi.org/10.1007/s11064-004-6876-y
Autor:
Joseph T. Neary, Cheikh I. Seye, Nataliya E. Chorna, Fernando A. González, Laurie Erb, Laura I. Santiago-Pérez, Grace Y. Sun, Gary A. Weisman
Publikováno v:
Journal of Neurochemistry. 91:119-132
Mechanical or ischemic trauma to the CNS causes the release of nucleotides and other neurotransmitters into the extracellular space. Nucleotides can activate nucleotide receptors that modulate the expression of genes implicated in cellular adaptive r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c9019c88d1cb4491b5c2a1bf16f0b3f
https://doi.org/10.1111/j.1471-4159.2004.02699.x
https://doi.org/10.1111/j.1471-4159.2004.02699.x
Autor:
Fernando A. González, Richard Rodnight, Gary A. Weisman, Qiongman Kong, Zhongji Liao, Guido Lenz, Joseph T. Neary, Yuan Kang, Minh D. Tran, Maria C. Jacques-Silva
Publikováno v:
British Journal of Pharmacology. 141:1106-1117
Emerging evidence indicates that nucleotide receptors are widely expressed in the nervous system. Here, we present evidence that P2Y and P2X receptors, particularly the P2X7 subtype, are coupled to the phosphoinositide 3-kinase (PI3K)/Akt pathway in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea872b079404485daf7b3e0acf5312c8
https://doi.org/10.1038/sj.bjp.0705685
https://doi.org/10.1038/sj.bjp.0705685
Autor:
Marta Fumagalli, Flaminio Cattabeni, Joseph T. Neary, Lorenzo Cottini, Paul R. Schiller, Maria P. Abbracchio, Roberta Brambilla
Publikováno v:
Drug Development Research. 59:161-170
Exposure of rat cortical astrocytes to αβmethyleneATP results in features of reactive astrogliosis via activation of a novel P2Y receptor linked to cyclooxygenase-2 (COX-2) upregulation [Brambilla et al., J Neurochem 2002, 83:1285-1296]. Here, we h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d41777da3a439eab084bdb9bf7d078fd
https://doi.org/10.1002/ddr.10217
https://doi.org/10.1002/ddr.10217