Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Joseph T. Crossno"'
Autor:
Chrystelle V. Garat, Susan M. Majka, Timothy M. Sullivan, Joseph T. Crossno, Jane E.B. Reusch, Dwight J. Klemm
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Levels of the cAMP-responsive transcription factor, CREB, are reduced in medial smooth muscle cells in remodeled pulmonary arteries from hypertensive calves and rats with chronic hypoxia-induced pulmonary hypertension. Here, we show that chronic hypo
Externí odkaz:
https://doaj.org/article/c782a2b0136c4237a7b0dd49b2f693aa
Autor:
Ananya Chakraborty, Abinaya Nathan, Mark Orcholski, Stuti Agarwal, Elya A. Shamskhou, Natasha Auer, Ankita Mitra, Eleana Stephanie Guardado, Gowri Swaminathan, David F. Condon, Joyce Yu, Matthew McCarra, Nicholas H. Juul, Alden Mallory, Roberto A. Guzman-Hernandez, Ke Yuan, Vanesa Rojas, Joseph T. Crossno, Lai-Ming Yung, Paul B. Yu, Thomas Spencer, Robert A. Winn, Andrea Frump, Vijaya Karoor, Tim Lahm, Haley Hedlin, Jeffrey R. Fineman, Robert Lafyatis, Carsten N. F. Knutsen, Cristina M. Alvira, David N. Cornfield, Vinicio A. de Jesus Perez
Publikováno v:
European Respiratory Journal. :2201625
IntroductionPulmonary arterial hypertension (PAH) is characterized by loss of microvessels. The Wnt pathways control pulmonary angiogenesis, but their role in PAH is incompletely understood. We hypothesized that Wnt activation in pulmonary microvascu
Autor:
Dwight J. Klemm, Chrystelle V. Garat, Timothy M. Sullivan, Jane E.B. Reusch, Joseph T. Crossno, Susan M. Majka
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Levels of the cAMP-responsive transcription factor, CREB, are reduced in medial smooth muscle cells in remodeled pulmonary arteries from hypertensive calves and rats with chronic hypoxia-induced pulmonary hypertension. Here, we show that chronic hypo
Autor:
Elya A. Shamskhou, Ananya Chakraborty, Mark Orcholski, Robert A. Winn, Thomas E. Spencer, V. De Jesus Perez, Joseph T. Crossno, Ke Yuan
Publikováno v:
A97. STATION TO STATION: UNRAVELING THE MOLECULAR PATHOGENESIS OF PAH.
Publikováno v:
Journal of Cardiovascular Pharmacology. 62:539-548
Hypoxia-induced pulmonary hypertension is characterized by progressive remodeling of the pulmonary artery (PA) system and loss of the transcription factor, cAMP response element binding protein (CREB) in PA smooth muscle cells (SMCs). Previous in vit
Autor:
Dennis M. Lyu, Joseph T. Crossno, Todd J. Grazia, Kelly E. Schoeppler, Martin R. Zamora, Katherine M. Vandervest
Publikováno v:
American Journal of Transplantation. 13:376-382
Evidence supports the use of 12 months of cytomegalovirus prophylaxis in all at-risk lung transplants; whether cytomegalovirus serostatus can be used to further optimize this duration remains to be determined. The purpose of this retrospective study
Autor:
Ronald G. Gill, Robert J. Plenter, Martin R. Zamora, Helen M. Lepper, Todd J. Grazia, Joseph T. Crossno, Francisco Victorino, Biagio A. Pietra, Shelley D. Miyamoto
Publikováno v:
American Journal of Transplantation. 11:34-44
Autologous CD117(+) progenitor cells (PC) have been successfully utilized in myocardial infarction and ischemic injury, potentially through the replacement/repair of damaged vascular endothelium. To date, such cells have not been used to enhance soli
Publikováno v:
Journal of Cardiovascular Pharmacology. 55:469-480
The transcription factor CREB is diminished in smooth muscle cells (SMCs) in remodeled, hypertensive pulmonary arteries (PAs) in animals exposed to chronic hypoxia. Forced depletion of cyclic adenosine monophosphate response element binding protein (
Autor:
Dwight J. Klemm, Molly White, Joe. M. McCord, Martha C. Tissot van Patot, Susan M. Majka, David Irwin, Joseph T. Crossno, Ginny Beckly, Eva Nozik-Grayck, Sonia C. Flores, T. Sullivan, Ben Foreman, Damian M. Bailey
Publikováno v:
Free Radical Biology and Medicine. 47:55-61
Acute hypoxia causes pulmonary vascular leak and is involved in the pathogenesis of pulmonary edema associated with inflammation, acute altitude exposure, and other critical illnesses. Reactive oxygen species, HIF-1, and VEGF have all been implicated
Autor:
Dwight J. Klemm, Chrystelle Garat, Kenneth G. Morris, Joseph T. Crossno, Kurt R. Stenmark, Ivan F. McMurtry, Edward C. Dempsey, Jane E.B. Reusch
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 292:L885-L897
Thiazolidinediones (TZDs) are insulin-sensitizing agents that also decrease systemic blood pressure, attenuate the formation of atherosclerotic lesions, and block remodeling of injured arterial walls. Recently, TZDs were shown to prevent pulmonary ar