Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Joseph T. Clark"'
Autor:
Joseph A. Pereira, Zachary Lanzar, Joseph T. Clark, Andrew P. Hart, Bonnie B. Douglas, Lindsey Shallberg, Keenan O’Dea, David A. Christian, Christopher A. Hunter
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
At homeostasis, a substantial proportion of Foxp3+ T regulatory cells (Tregs) have an activated phenotype associated with enhanced TCR signals and these effector Treg cells (eTregs) co-express elevated levels of PD-1 and CTLA-4. Short term in vivo bl
Externí odkaz:
https://doaj.org/article/ca90c2086bee408fa59ebce36148ce51
Autor:
Joseph T. Clark, Orr-El Weizman, Daniel L. Aldridge, Lindsey A. Shallberg, Julia Eberhard, Zachary Lanzar, Devon Wasche, John D. Huck, Ting Zhou, Aaron M. Ring, Christopher A. Hunter
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112147- (2023)
Summary: Interleukin-18 (IL-18) promotes natural killer (NK) and T cell production of interferon (IFN)-γ, a key factor in resistance to Toxoplasma gondii, but previous work has shown a limited role for endogenous IL-18 in control of this parasite. A
Externí odkaz:
https://doaj.org/article/946478da46cf4bad973624d502c6ee12
Autor:
Daniel P. Dever, Samantha G. Scharenberg, Joab Camarena, Eric J. Kildebeck, Joseph T. Clark, Renata M. Martin, Rasmus O. Bak, Yuming Tang, Monika Dohse, Johannes A. Birgmeier, Karthik A. Jagadeesh, Gill Bejerano, Ann Tsukamoto, Natalia Gomez-Ospina, Nobuko Uchida, Matthew H. Porteus
Publikováno v:
iScience, Vol 15, Iss , Pp 524-535 (2019)
Summary: Human neural stem cells (NSCs) offer therapeutic potential for neurodegenerative diseases, such as inherited monogenic nervous system disorders, and neural injuries. Gene editing in NSCs (GE-NSCs) could enhance their therapeutic potential. W
Externí odkaz:
https://doaj.org/article/2fa9e32ecf84457fb9e04fdb55b3dba9
Autor:
Ayal Hendel, Eric J. Kildebeck, Eli J. Fine, Joseph T. Clark, Niraj Punjya, Vittorio Sebastiano, Gang Bao, Matthew H. Porteus
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 293-305 (2014)
Targeted genome editing with engineered nucleases has transformed the ability to introduce precise sequence modifications at almost any site within the genome. A major obstacle to probing the efficiency and consequences of genome editing is that no e
Externí odkaz:
https://doaj.org/article/857318927be440c7959361fa1a17cf4a
Autor:
Jennifer E Dumaine, Adam Sateriale, Alexis R Gibson, Amita G Reddy, Jodi A Gullicksrud, Emma N Hunter, Joseph T Clark, Boris Striepen
Publikováno v:
eLife, Vol 10 (2021)
The parasite Cryptosporidium is responsible for diarrheal disease in young children causing death, malnutrition, and growth delay. Cryptosporidium invades enterocytes where it develops in a unique intracellular niche. Infected cells exhibit profound
Externí odkaz:
https://doaj.org/article/ae430fdaa3064faba2888e2acc41c05f
Autor:
Joseph T Clark, David A Christian, Jodi A Gullicksrud, Joseph A Perry, Jeongho Park, Maxime Jacquet, James C Tarrant, Enrico Radaelli, Jonathan Silver, Christopher A Hunter
Publikováno v:
eLife, Vol 10 (2021)
IL-33 is an alarmin required for resistance to the parasite Toxoplasma gondii, but its role in innate resistance to this organism is unclear. Infection with T. gondii promotes increased stromal cell expression of IL-33, and levels of parasite replica
Externí odkaz:
https://doaj.org/article/52e090cac47b4fec91345db4426581e2
Autor:
Joseph A. Perry, Lindsey Shallberg, Joseph T. Clark, Jodi A. Gullicksrud, Jonathan H. DeLong, Bonnie B. Douglas, Andrew P. Hart, Zachary Lanzar, Keenan O’Dea, Christoph Konradt, Jeongho Park, Juhi R. Kuchroo, Daniel Grubaugh, Arielle Glatman Zaretsky, Igor E. Brodsky, Rene de Waal Malefyt, David A. Christian, Arlene H. Sharpe, Christopher A. Hunter
Publikováno v:
Nature Immunology. 23:743-756
Autor:
David A. Christian, Thomas A. Adams, Lindsey A. Shallberg, Anthony T. Phan, Tony E. Smith, Mosana Abraha, Joseph Perry, Gordon Ruthel, Joseph T. Clark, Gretchen Harms Pritchard, Lillian R. Aronson, Selamawit Gossa, Dorian B. McGavern, Ross M. Kedl, Christopher A. Hunter
Publikováno v:
Sci Immunol
In the peritoneal cavity, the omentum contains fat-associated lymphoid clusters (FALCs) whose role in response to infection is poorly understood. After intraperitoneal immunization with Toxoplasma gondii , conventional type 1 dendritic cells (cDC1s)
Autor:
Joseph A. Perry, Zachary Lanzar, Joseph T. Clark, Andrew P. Hart, Bonnie B. Douglas, Lindsey Shallberg, Keenan O’Dea, David A. Christian, Christopher A. Hunter
At homeostasis, a substantial proportion of Foxp3+ T regulatory cells (Tregs) have an activated phenotype associated with enhanced TCR signals and these effector Treg cells (eTregs) co-express elevated levels of PD-1 and CTLA-4. Short term in vivo bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acd9aee4d2d29a78b19409ae41da1a32
https://doi.org/10.1101/2022.07.22.501159
https://doi.org/10.1101/2022.07.22.501159