Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Joseph T. Bruder"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 330-343 (2023)
Impairment of GABAergic inhibitory neuronal function is linked to epilepsy and other neurological and psychiatric disorders. Recombinant adeno-associated virus (rAAV)-based gene therapy targeting GABAergic neurons is a promising treatment for GABA-as
Externí odkaz:
https://doaj.org/article/633f6c85c70a407c989042e89a913a96
Autor:
Bradley S. Hollidge, Hayley B. Carroll, Randolph Qian, Madison L. Fuller, April R. Giles, Andrew C. Mercer, Olivier Danos, Ye Liu, Joseph T. Bruder, Jared B. Smith
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Understanding the kinetics and durability of AAV-mediated transgene expression in the brain is essential for conducting basic neuroscience studies as well as for developing gene therapy approaches for CNS diseases. Here, we characterize and compare t
Externí odkaz:
https://doaj.org/article/211584121410446c9ae0775d23eb5024
Autor:
Alexander W.M. Hooper, Hayes Wong, Yosuke Niibori, Rozita Abdoli, Subha Karumuthil-Melethil, Chunping Qiao, Olivier Danos, Joseph T. Bruder, David R. Hampson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 196-209 (2021)
Fragile X syndrome (FXS), a neurodevelopmental disorder with no known cure, is caused by a lack of expression of the fragile X mental retardation protein (FMRP). As a single-gene disorder, FXS is an excellent candidate for viral-vector-based gene the
Externí odkaz:
https://doaj.org/article/39f2762e4bc2409e975a474aed179042
Autor:
Kazuki Sawamoto, Subha Karumuthil-Melethil, Shaukat Khan, Molly Stapleton, Joseph T. Bruder, Olivier Danos, Shunji Tomatsu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 50-61 (2020)
Mucopolysaccharidosis type IVA (MPS IVA) is due to the deficiency of GALNS (N-acetylgalactosamine 6-sulfate sulfatase) and is characterized by systemic skeletal dysplasia. We have evaluated adeno-associated virus 8 (AAV8) vectors expressing different
Externí odkaz:
https://doaj.org/article/1d90572cb68b45238af54e6b5e927c79
Autor:
Hayes Wong, Alexander W.M. Hooper, Yosuke Niibori, Shiron J. Lee, Luca A. Hategan, Liang Zhang, Subha Karumuthil-Melethil, Sally M. Till, Peter C. Kind, Olivier Danos, Joseph T. Bruder, David R. Hampson
Publikováno v:
Neurobiology of Disease, Vol 146, Iss , Pp 105118- (2020)
Fragile X syndrome (FXS), a neurodevelopmental disorder with autistic features, is caused by the loss of the fragile X mental retardation protein. Sex-specific differences in the clinical profile have been observed in FXS patients, but few studies ha
Externí odkaz:
https://doaj.org/article/408689585b4c4ab0b7a92f55b5b78196
Autor:
Joseph T. Bruder, Ping Chen, Greg Ekberg, Emily C. Smith, Christopher A. Lazarski, Bennett A. Myers, Jessica Bolton, Martha Sedegah, Eileen Villasante, Thomas L. Richie, C. Richter King, Joao C. Aguiar, Denise L. Doolan, Douglas E. Brough
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 7, Iss C, Pp 20-31 (2017)
T cells are critical effectors of host immunity that target intracellular pathogens, such as the causative agents of HIV, tuberculosis, and malaria. The development of vaccines that induce effective cell-mediated immunity against such pathogens has p
Externí odkaz:
https://doaj.org/article/87ae21e3c62d43e7adcd0df59c011f76
Autor:
Keith Limbach, Maureen Stefaniak, Ping Chen, Noelle B. Patterson, Grant Liao, Shaojie Weng, Svetlana Krepkiy, Greg Ekberg, Holly Torano, Damodar Ettyreddy, Kalpana Gowda, Sharvari Sonawane, Arnel Belmonte, Esteban Abot, Martha Sedegah, Michael R. Hollingdale, Ann Moormann, John Vulule, Eileen Villasante, Thomas L. Richie, Douglas E. Brough, Joseph T. Bruder
Publikováno v:
Malaria Journal, Vol 16, Iss 1, Pp 1-12 (2017)
Abstract Background A DNA-human Ad5 (HuAd5) prime-boost malaria vaccine has been shown to protect volunteers against a controlled human malaria infection. The potency of this vaccine, however, appeared to be affected by the presence of pre-existing i
Externí odkaz:
https://doaj.org/article/16f9c4217eb9443ea1a9be99f6391e9f
Autor:
Joseph T. Bruder, Elena Semenova, Ping Chen, Keith Limbach, Noelle B. Patterson, Maureen E. Stefaniak, Svetlana Konovalova, Charlie Thomas, Melissa Hamilton, C. Richter King, Thomas L. Richie, Denise L. Doolan
Publikováno v:
PLoS ONE, Vol 7, Iss 5 (2012)
Externí odkaz:
https://doaj.org/article/399a97eb8c624818ac3aba0381f78548
Autor:
Matthew Piechnik, Paige C. Amendum, Kazuki Sawamoto, Molly Stapleton, Shaukat Khan, Nidhi Fnu, Victor Álvarez, Angelica Maria Herreño Pachon, Olivier Danos, Joseph T. Bruder, Subha Karumuthil-Melethil, Shunji Tomatsu
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 20; Pages: 12693
Adeno-associated virus (AAV) vector-based therapies can effectively correct some disease pathology in murine models with mucopolysaccharidoses. However, immunogenicity can limit therapeutic effect as immune responses target capsid proteins, transduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c3b2d0ff5777290423eb717e88e027
Autor:
Thomas L. Richie, Emily C. Smith, Douglas E. Brough, Joao C. Aguiar, Jessica Bolton, Bennett A. Myers, Martha Sedegah, C. Richter King, Christopher A. Lazarski, Eileen Villasante, Ping Chen, Joseph T. Bruder, Greg Ekberg, Denise L. Doolan
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 7, Iss C, Pp 20-31 (2017)
Molecular Therapy: Methods & Clinical Development, Vol 7, Iss C, Pp 20-31 (2017)
T cells are critical effectors of host immunity that target intracellular pathogens, such as the causative agents of HIV, tuberculosis, and malaria. The development of vaccines that induce effective cell-mediated immunity against such pathogens has p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448fe6f74c64e325724817749785697a
http://europepmc.org/articles/PMC5602877
http://europepmc.org/articles/PMC5602877