Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Joseph T Nickels"'
Autor:
Michelle L Villasmil, Antonio Daniel Barbosa, Jessie Lee Cunningham, Symeon Siniossoglou, Joseph T Nickels
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235746 (2020)
Azole resistant fungal infections remain a health problem for the immune compromised. Current therapies are limited due to rises in new resistance mechanisms. Therefore, it is important to identify new drug targets for drug discovery and novel therap
Externí odkaz:
https://doaj.org/article/69957f3095894e4e9a1f75421cbf0efb
Autor:
Muhua Yang, Joseph T. Nickels
Publikováno v:
Diseases, Vol 3, Iss 3, Pp 176-192 (2015)
Metabolic syndrome is an ever-increasing health problem among the world’s population. It is a group of intertwined maladies that includes obesity, hypertriglyceridemia, hypertension, nonalcoholic fatty liver disease (NAFLD), and diabetes mellitus t
Externí odkaz:
https://doaj.org/article/e0bfb562ed09420da924c6f8624b8e36
Autor:
Raymond G. Franks, Dividutta Das, Alyssa M. Brown, Michael Hayward, Joseph T. Nickels, Jessie Lee Cunningham, Karla K. Frietze
Publikováno v:
Autophagy
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease globally. NAFLD is a consequence of fat accumulation in the liver leading to lipotoxicity. Increasing evidence has demonstrated the critical role of autophagy in N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d2934fe907298698b05282eeccd841
https://doi.org/10.1080/15548627.2021.1920818
https://doi.org/10.1080/15548627.2021.1920818
Autor:
Karla K. Frietze, Michael Hayward, Weidong Liu, Jessie Lee Cunningham, Joshua Wayne, Alyssa D. Brown, Joseph T. Nickels
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::884b90aff544dbb9881012c9887441bb
https://doi.org/10.1096/fasebj.2021.35.s1.05274
https://doi.org/10.1096/fasebj.2021.35.s1.05274
Autor:
Virginia McDonough, Muhua Yang, Joseph T. Nickels, Christina Gallo-Ebert, Michael Hayward, Weidong Liu
Publikováno v:
Molecular and Cellular Biology. 40
Genome-wide association studies (GWAS) have linked IGF2BP2 single-nucleotide polymorphisms (SNPs) with type 2 diabetes (T2D). Mice overexpressing mIGF2BP2 have elevated cholesterol levels when fed a diet that induces hepatic steatosis. These and othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64556d0ce7b2632927e08f70936dfeb3
https://doi.org/10.1128/mcb.00058-20
https://doi.org/10.1128/mcb.00058-20
Autor:
Muhua, Yang, Christina, Gallo-Ebert, Michael, Hayward, Weidong, Liu, Virginia, McDonough, Joseph T, Nickels
Publikováno v:
Mol Cell Biol
Genome-wide association studies (GWAS) have linked IGF2BP2 single-nucleotide polymorphisms (SNPs) with type 2 diabetes (T2D). Mice overexpressing mIGF2BP2 have elevated cholesterol levels when fed a diet that induces hepatic steatosis. These and othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2477cbdc24d8a84aa9fc7223ba8ec690
https://pubmed.ncbi.nlm.nih.gov/32482798
https://pubmed.ncbi.nlm.nih.gov/32482798
Autor:
Hsing-Yin Liu, Olesia Buiakova, Michael Hayward, Kinnari Modi, Riley Draper, Jamie Francisco, Beverly K. Jones, Christina Gallo-Ebert, Virginia McDonough, Joseph T. Nickels
Publikováno v:
Journal of Biological Chemistry. 293:5956-5974
Metabolic syndrome (MetS) is a term used to characterize individuals having at least three of the following diseases: obesity, dyslipidemia, hyperglycemia, insulin resistance, hypertension, and nonalcoholic fatty liver disease (NAFLD). It is widespre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6312e22280e05b05e52af2971d379d1
https://doi.org/10.1074/jbc.ra117.000800
https://doi.org/10.1074/jbc.ra117.000800
Autor:
Joseph T. Nickels
Publikováno v:
J Lipid Res
Pathogenic organisms may be sensitive to inhibitors of sterol biosynthesis, which carry antimetabolite properties, through manipulation of the key enzyme, sterol methyltransferase (SMT). Here, we isolated natural suicide substrates of the ergosterol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9e204db2b2760dfb13d2122a0b4d52
https://doi.org/10.1194/jlr.c094250
https://doi.org/10.1194/jlr.c094250
Autor:
Melissa Donigan, Hsing-Yin Liu, Adam Bata, Josie E. Parker, Joseph T. Nickels, Steven L. Kelly, Caroline Giordano, Paula McCourt, Christina Gallo-Ebert
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 11, Pp 3455-3465 (2016)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
Candida albicans is an opportunistic fungus responsible for the majority of systemic fungal infections. Multiple factors contribute to C. albicans pathogenicity. C. albicans strains lacking CaArv1 are avirulent. Arv1 has a conserved Arv1 homology dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43150317ff307bb7b7cf8ab2e978ecb4
https://doi.org/10.1534/g3.116.033969
https://doi.org/10.1534/g3.116.033969
Autor:
Joseph T. Nickels, Antonio Daniel Barbosa, Symeon Siniossoglou, Michelle L. Villasmil, Jessie Lee Cunningham
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0235746 (2020)
PLoS ONE, Vol 15, Iss 7, p e0235746 (2020)
Azole resistant fungal infections remain a health problem for the immune compromised. Current therapies are limited due to rises in new resistance mechanisms. Therefore, it is important to identify new drug targets for drug discovery and novel therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f02142288cb64a49105676afb7244603
https://doi.org/10.1371/journal.pone.0235746
https://doi.org/10.1371/journal.pone.0235746