Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Joseph T Bruder"'
Autor:
Neal N Padte, Mar Boente-Carrera, Chasity D Andrews, Jenny McManus, Brooke F Grasperge, Agegnehu Gettie, Jordana G Coelho-dos-Reis, Xiangming Li, Douglass Wu, Joseph T Bruder, Martha Sedegah, Noelle Patterson, Thomas L Richie, Chi-Huey Wong, David D Ho, Sandhya Vasan, Moriya Tsuji
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78407 (2013)
A key strategy to a successful vaccine against malaria is to identify and develop new adjuvants that can enhance T-cell responses and improve protective immunity. Upon co-administration with a rodent malaria vaccine in mice, 7DW8-5, a recently identi
Externí odkaz:
https://doaj.org/article/9f9aeffae151400bbaac60e368566594
Autor:
Ilin Chuang, Martha Sedegah, Susan Cicatelli, Michele Spring, Mark Polhemus, Cindy Tamminga, Noelle Patterson, Melanie Guerrero, Jason W Bennett, Shannon McGrath, Harini Ganeshan, Maria Belmonte, Fouzia Farooq, Esteban Abot, Jo Glenna Banania, Jun Huang, Rhonda Newcomer, Lisa Rein, Dianne Litilit, Nancy O Richie, Chloe Wood, Jittawadee Murphy, Robert Sauerwein, Cornelus C Hermsen, Andrea J McCoy, Edwin Kamau, James Cummings, Jack Komisar, Awalludin Sutamihardja, Meng Shi, Judith E Epstein, Santina Maiolatesi, Donna Tosh, Keith Limbach, Evelina Angov, Elke Bergmann-Leitner, Joseph T Bruder, Denise L Doolan, C Richter King, Daniel Carucci, Sheetij Dutta, Lorraine Soisson, Carter Diggs, Michael R Hollingdale, Christian F Ockenhouse, Thomas L Richie
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55571 (2013)
Gene-based vaccination using prime/boost regimens protects animals and humans against malaria, inducing cell-mediated responses that in animal models target liver stage malaria parasites. We tested a DNA prime/adenovirus boost malaria vaccine in a Ph
Externí odkaz:
https://doaj.org/article/29ce14248ad349cd876816870b787f25
Autor:
Joseph T Bruder, Elena Semenova, Ping Chen, Keith Limbach, Noelle B Patterson, Maureen E Stefaniak, Svetlana Konovalova, Charlie Thomas, Melissa Hamilton, C Richter King, Thomas L Richie, Denise L Doolan
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e33920 (2012)
The development of an effective malaria vaccine is a high global health priority. Vaccine vectors based on adenovirus type 5 are capable of generating robust and protective T cell and antibody responses in animal models and are currently being evalua
Externí odkaz:
https://doaj.org/article/a5d21dfeacc34529810ff1df47ca014f
Autor:
Martha Sedegah, Cindy Tamminga, Shannon McGrath, Brent House, Harini Ganeshan, Jennylynn Lejano, Esteban Abot, Glenna J Banania, Renato Sayo, Fouzia Farooq, Maria Belmonte, Nalini Manohar, Nancy O Richie, Chloe Wood, Carole A Long, David Regis, Francis T Williams, Meng Shi, Ilin Chuang, Michele Spring, Judith E Epstein, Jose Mendoza-Silveiras, Keith Limbach, Noelle B Patterson, Joseph T Bruder, Denise L Doolan, C Richter King, Lorraine Soisson, Carter Diggs, Daniel Carucci, Sheetij Dutta, Michael R Hollingdale, Christian F Ockenhouse, Thomas L Richie
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e24586 (2011)
Models of immunity to malaria indicate the importance of CD8+ T cell responses for targeting intrahepatic stages and antibodies for targeting sporozoite and blood stages. We designed a multistage adenovirus 5 (Ad5)-vectored Plasmodium falciparum mala
Externí odkaz:
https://doaj.org/article/9c9a093b9e1d42e4bfd2af438749573f
Autor:
Cindy Tamminga, Martha Sedegah, David Regis, Ilin Chuang, Judith E Epstein, Michele Spring, Jose Mendoza-Silveiras, Shannon McGrath, Santina Maiolatesi, Sharina Reyes, Victoria Steinbeiss, Charlotte Fedders, Kathryn Smith, Brent House, Harini Ganeshan, Jennylynn Lejano, Esteban Abot, Glenna J Banania, Renato Sayo, Fouzia Farooq, Maria Belmonte, Jittawadee Murphy, Jack Komisar, Jackie Williams, Meng Shi, Donald Brambilla, Nalini Manohar, Nancy O Richie, Chloe Wood, Keith Limbach, Noelle B Patterson, Joseph T Bruder, Denise L Doolan, C Richter King, Carter Diggs, Lorraine Soisson, Daniel Carucci, Gail Levine, Sheetij Dutta, Michael R Hollingdale, Christian F Ockenhouse, Thomas L Richie
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25868 (2011)
A protective malaria vaccine will likely need to elicit both cell-mediated and antibody responses. As adenovirus vaccine vectors induce both these responses in humans, a Phase 1/2a clinical trial was conducted to evaluate the efficacy of an adenoviru
Externí odkaz:
https://doaj.org/article/97a1ce60fb5e4006ae377a92a4081a31
Autor:
George Jiang, Meng Shi, Solomon Conteh, Nancy Richie, Glenna Banania, Harini Geneshan, Anais Valencia, Priti Singh, Joao Aguiar, Keith Limbach, Kurt I Kamrud, Jonathan Rayner, Jonathan Smith, Joseph T Bruder, C Richter King, Takafumi Tsuboi, Satoru Takeo, Yaeta Endo, Denise L Doolan, Thomas L Richie, Walter R Weiss
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6559 (2009)
Using newer vaccine platforms which have been effective against malaria in rodent models, we tested five immunization regimens against Plasmodium knowlesi in rhesus monkeys. All vaccines included the same four P. knowlesi antigens: the pre-erythrocyt
Externí odkaz:
https://doaj.org/article/9e6e88399c3947899ccd9b821b2fadf7
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 330-343 (2023)
Impairment of GABAergic inhibitory neuronal function is linked to epilepsy and other neurological and psychiatric disorders. Recombinant adeno-associated virus (rAAV)-based gene therapy targeting GABAergic neurons is a promising treatment for GABA-as
Externí odkaz:
https://doaj.org/article/633f6c85c70a407c989042e89a913a96
Autor:
Bradley S. Hollidge, Hayley B. Carroll, Randolph Qian, Madison L. Fuller, April R. Giles, Andrew C. Mercer, Olivier Danos, Ye Liu, Joseph T. Bruder, Jared B. Smith
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Understanding the kinetics and durability of AAV-mediated transgene expression in the brain is essential for conducting basic neuroscience studies as well as for developing gene therapy approaches for CNS diseases. Here, we characterize and compare t
Externí odkaz:
https://doaj.org/article/211584121410446c9ae0775d23eb5024
Autor:
Alexander W.M. Hooper, Hayes Wong, Yosuke Niibori, Rozita Abdoli, Subha Karumuthil-Melethil, Chunping Qiao, Olivier Danos, Joseph T. Bruder, David R. Hampson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 196-209 (2021)
Fragile X syndrome (FXS), a neurodevelopmental disorder with no known cure, is caused by a lack of expression of the fragile X mental retardation protein (FMRP). As a single-gene disorder, FXS is an excellent candidate for viral-vector-based gene the
Externí odkaz:
https://doaj.org/article/39f2762e4bc2409e975a474aed179042
Autor:
Matthew Piechnik, Paige C. Amendum, Kazuki Sawamoto, Molly Stapleton, Shaukat Khan, Nidhi Fnu, Victor Álvarez, Angelica Maria Herreño Pachon, Olivier Danos, Joseph T. Bruder, Subha Karumuthil-Melethil, Shunji Tomatsu
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12693 (2022)
Adeno-associated virus (AAV) vector-based therapies can effectively correct some disease pathology in murine models with mucopolysaccharidoses. However, immunogenicity can limit therapeutic effect as immune responses target capsid proteins, transduce
Externí odkaz:
https://doaj.org/article/1ad44dfbf6134a6093180066ae8bb01a