Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Joseph Silburt"'
Autor:
Joseph Silburt, Isabelle Aubert
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-20 (2022)
Abstract Background In conditions of brain injury and degeneration, defining microglial and astrocytic activation using cellular markers alone remains a challenging task. We developed the MORPHIOUS software package, an unsupervised machine learning w
Externí odkaz:
https://doaj.org/article/be67cb657ff143eebcdf2d650a63886f
Autor:
Rikke Hahn Kofoed, Stefan Heinen, Joseph Silburt, Sonam Dubey, Chinaza Lilian Dibia, Miriam Maes, Elizabeth M. Simpson, Kullervo Hynynen, Isabelle Aubert
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 390-405 (2021)
Efficient disease-modifying treatments for Alzheimer disease, the most common form of dementia, have yet to be established. Gene therapy has the potential to provide the long-term production of therapeutic in the brain following a single administrati
Externí odkaz:
https://doaj.org/article/2fac79d9eff6473f8934f1dbcffeddbc
Autor:
Danielle Weber-Adrian, Rikke Hahn Kofoed, Joseph Silburt, Zeinab Noroozian, Kairavi Shah, Alison Burgess, Shawna Rideout, Sebastian Kügler, Kullervo Hynynen, Isabelle Aubert
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Non-surgical gene delivery to the brain can be achieved following intravenous injection of viral vectors coupled with transcranial MRI-guided focused ultrasound (MRIgFUS) to temporarily and locally permeabilize the blood–brain barrier. Vec
Externí odkaz:
https://doaj.org/article/4d292ee5b9e644b58491675946f97773
Autor:
Zeinab Noroozian, Joseph Silburt, Josephine Wing Yee Chan, Rikke Hahn Kofoed, Isabelle Aubert, Danielle Weber-Adrian, Sebastian Kügler, Kullervo Hynynen
Publikováno v:
Theranostics
Gene therapy can be designed to efficiently counter pathological features characteristic of neurodegenerative disorders. Here, we took advantage of the glial fibrillary acidic protein (GFAP) promoter to preferentially enhance transgene expression nea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7340f6c29b2faa1448cf35b4d582c587
https://doi.org/10.7150/thno.36718
https://doi.org/10.7150/thno.36718
Autor:
Joseph Silburt, Isabelle Aubert
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-20 (2022)
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-20 (2022)
Background In conditions of brain injury and degeneration, defining microglial and astrocytic activation using cellular markers alone remains a challenging task. We developed the MORPHIOUS software package, an unsupervised machine learning workflow w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2311b8c34bf8912aa8380f850881b09f
https://pubmed.ncbi.nlm.nih.gov/35093113
https://pubmed.ncbi.nlm.nih.gov/35093113
Autor:
Isabelle Aubert, Joseph Silburt
In cases of brain injury, degeneration and repair, defining microglia and astrocytic activation using cellular markers alone remains a challenging task. We developed MORPHIOUS, an unsupervised machine learning workflow that utilizes a one-class suppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::197dc0b51cd84a4793f7acafaa9fc64c
https://doi.org/10.1101/2020.08.17.251843
https://doi.org/10.1101/2020.08.17.251843
Autor:
Kullervo Hynynen, Shawna Rideout, Alison Burgess, Zeinab Noroozian, Joseph Silburt, Isabelle Aubert, Danielle Weber-Adrian, Sebastian Kügler, Kairavi Shah, Rikke Hahn Kofoed
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Non-surgical gene delivery to the brain can be achieved following intravenous injection of viral vectors coupled with transcranial MRI-guided focused ultrasound (MRIgFUS) to temporarily and locally permeabilize the blood–brain barrier. Vector and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db35b3d278efa5c948f847512f42159
https://pubmed.ncbi.nlm.nih.gov/33479314
https://pubmed.ncbi.nlm.nih.gov/33479314
Publikováno v:
The Journal of Neuroscience. 36:12296-12298
The blood-brain barrier is a highly selective anatomical and functional interface allowing a unique environment for neuro-glia networks. Blood-brain barrier dysfunction is common in most brain disorders and is associated with disease course and delay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ae4931a2cffcf7e0477e4939f20875
https://doi.org/10.1523/jneurosci.2962-16.2016
https://doi.org/10.1523/jneurosci.2962-16.2016
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Transcranial focused ultrasound (FUS) is promising for the treatment of neurological disorders, and the brain’s response to FUS requires full consideration for a safe translation to the clinic. The study by Kovacs et al. (1) provides insights into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35270013ba5f14bba2e6b2790da7d6f6
https://doi.org/10.1073/pnas.1710761114
https://doi.org/10.1073/pnas.1710761114
Publikováno v:
Journal of neurochemistry. 140(2)
Read the highlighted article 'Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells' on page 216.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05dcb6a18de683f1eb2d3536a63f4d5
https://pubmed.ncbi.nlm.nih.gov/27976378
https://pubmed.ncbi.nlm.nih.gov/27976378