Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Joseph Seco"'
Autor:
Aislyn D W Boran, Joseph Seco, Vinodh Jayaraman, Gomathi Jayaraman, Shan Zhao, Sushmitha Reddy, Yibang Chen, Ravi Iyengar
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49702 (2012)
The epidermal growth factor receptor (EGFR) is involved in many cancers and EGFR has been heavily pursued as a drug target. Drugs targeting EGFR have shown promising clinical results for several cancer types. However, resistance to EGFR inhibitors of
Externí odkaz:
https://doaj.org/article/fd41bd35e3254e84bfb4509bb011c156
Autor:
Robert J Norgard, Pratha Budhani, Sarah O'Brian, Jessica Potts, Brianna Flynn, Xavier Salce, Joshua Tagore, Lucinda Thiede, Joseph Seco, Suzanne Segal, Mark Love, Ania Mikucka, Charlie Cote, Ruby Wasti, Mohanapriya Kamalakannan, Astrid Jeschko, Gabriela Melo-Zainzinger, Angela Mcnabola, Varenka Rodriguez Rodriguez DiBlasi, Joseph Tumang, Ulrike Tontsch-Grunt, Melanie Hinkel, Jeanine Pignatelli, Francesca Trapani, Sandra Martinez-Morilla, Kaja Kostyrko, Marco H Hofmann, Abhishek Kashyap, Emilio Flano, Kang Liu
Publikováno v:
Cancer Immunology Research. 10:B23-B23
KRAS is most frequently mutated in pancreatic adenocarcinomas (PDAC) with more than 90% of cases having a KRAS mutation. This leads to constitutive activation of the downstream signaling pathways, driving tumor cell proliferation whilst co-opting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23cdb26903f70506c8f0e4a9e01950f7
https://doi.org/10.1158/2326-6074.tumimm22-b23
https://doi.org/10.1158/2326-6074.tumimm22-b23