Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joseph Schragenheim"'
Autor:
David Sacerdoti, Shailendra P. Singh, Joseph Schragenheim, Lars Bellner, Luca Vanella, Marco Raffaele, Aliza Meissner, Ilana Grant, Gaia Favero, Rita Rezzani, Luigi F. Rodella, David Bamshad, Edward Lebovics, Nader G. Abraham
Publikováno v:
International Journal of Hepatology, Vol 2018 (2018)
Aim. Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress, and lipotoxicity. We hypothesize that an increase in the inflammatory adipokine NOV decreases antioxidant Heme Oxygenase 1 (
Externí odkaz:
https://doaj.org/article/2f59c4d9df324c50bc6b0e37fe9efbad
Autor:
Victor Garcia, Varunkumar Pandey, Lars Bellner, Kevin Agostinucci, Joseph Schragenheim, Mahesh P. Paudyal, Nader G. Abraham, Shailendra P. Singh, J. Capdevila, John R. Falck, Ankit Gilani, Michal L. Schwartzman
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 315:R934-R944
20-Hydroxyeicosatetraenoic acid (20-HETE) has been shown to positively correlate with body mass index, hyperglycemia, and plasma insulin levels. This study seeks to identify a causal relationship between 20-HETE and obesity-driven insulin resistance.
Autor:
Lars Bellner, Marco Raffaele, Darryl C. Zeldin, Shailendra P. Singh, Jian Cao, Nitin Puri, Nader G. Abraham, Joseph Schragenheim, J. Alyce Bradbury, Lu Liu, Luca Vanella
Publikováno v:
Prostaglandins & Other Lipid Mediators. 138:1-8
We have shown that epoxyeicosatrienoic acids (EETs), specifically 11,12- and 14,15-EETs, reduce adipogenesis in human mesenchymal stem cells and mouse preadipocytes (3T-3L1). In this study, we explore the effects of soluble epoxide hydrolase (sEH) de
Autor:
Shailendra P. Singh, Aliza Meissner, Edward Lebovics, Rita Rezzani, David Sacerdoti, David Bamshad, Luca Vanella, Lars Bellner, Ilana Grant, Marco Raffaele, Gaia Favero, Nader G. Abraham, Joseph Schragenheim, Luigi Fabrizio Rodella
Publikováno v:
International Journal of Hepatology, Vol 2018 (2018)
International Journal of Hepatology
International Journal of Hepatology
Aim. Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress, and lipotoxicity. We hypothesize that an increase in the inflammatory adipokine NOV decreases antioxidant Heme Oxygenase 1 (
Publikováno v:
Trends in Pharmacological Sciences. 37:945-962
Cardiovascular disease remains the leading cause of death worldwide. Among many potential targets for pharmacological intervention, a promising strategy involves epoxyeicosatrienoic acid (EET) and soluble epoxide hydroxylase (sEH) inhibition. sEH is
Autor:
Nader G. Abraham, Jian Cao, John R. Falck, Joseph Schragenheim, Lars Bellner, Shailendra P. Singh
Publikováno v:
Prostaglandins & Other Lipid Mediators. 125:8-18
Background/objectives Obesity is a risk factor in the development of type 2 diabetes mellitus (DM2), which is associated with increased morbidity and mortality, predominantly as a result of cardiovascular complications. Increased adiposity is a syste
Autor:
Nader G. Abraham, Charles T. Stier, Joseph Schragenheim, John A. McClung, David Bamshad, Joseph Rudman, Ilana Grant, Lars Bellner, Shailendra P. Singh, Aliza Meissner
Publikováno v:
The FASEB Journal. 32
Publikováno v:
The FASEB Journal. 32
Autor:
Falck, John A. McClung, Stephen J. Peterson, Joseph Schragenheim, Edith Hochhauser, Nader G. Abraham, Michael Arad, Shailendra Ps, Lars Bellner, Jeremy A. Weingarten, Jian Cao, Maayan Waldman
Publikováno v:
Cardiovascular Pharmacology: Open Access.
We have previously shown that an Epoxyeicosatrienoic Acid (EET) -agonist has pleiotropic effects and reverses cardiomyopathy by decreasing inflammatory molecules and increasing antioxidant signaling. We hypothesized that administration of an EET agon
Autor:
Jian Cao, Nader G. Abraham, Joseph Schragenheim, Lars Bellner, Attallah Kappas, Gregory Joseph, Shailendra P. Singh
Publikováno v:
Hypertension. 68
Background: Obesity and diabetes are independently associated with the development of cardiac events that occur in db mice that are linked to a decrease in heme oxygenase-1 (HO-1) and epoxyeicosatrienoics (EETs). An increase in HO-1 and EET levels is