Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Joseph Sarhan"'
Autor:
Hayley I. Muendlein, Joseph Sarhan, Beiyun C. Liu, Wilson M. Connolly, Stephen A. Schworer, Irina Smirnova, Amy Y. Tang, Vladimir Ilyukha, Jodie Pietruska, Soroush Tahmasebi, Nahum Sonenberg, Alexei Degterev, Alexander Poltorak
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 699-713.e4 (2020)
Summary: Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are well known for their capacity to drive necroptosis via mixed-lineage kinase-like domain (MLKL). Recently, RIPK1/3 kinase activity has been shown to drive inflammation via activa
Externí odkaz:
https://doaj.org/article/b14db846e8cc4f8c8f65d98ff6c63481
Autor:
Beiyun C. Liu, Joseph Sarhan, Alexander Panda, Hayley I. Muendlein, Vladimir Ilyukha, Jörn Coers, Masahiro Yamamoto, Ralph R. Isberg, Alexander Poltorak
Publikováno v:
Cell Reports, Vol 24, Iss 1, Pp 155-168.e5 (2018)
Summary: Legionella pneumophila elicits caspase-11-driven macrophage pyroptosis through guanylate-binding proteins (GBPs) encoded on chromosome 3. It has been proposed that microbe-driven IFN upregulates GBPs to facilitate pathogen vacuole rupture an
Externí odkaz:
https://doaj.org/article/217eebaf70ed4ee88874c232373dfad4
Autor:
Gautham K Rao, Albert Wong, Mark Collinge, Joseph Sarhan, Timur O Yarovinsky, Vinod S Ramgolam, Matthias Gaestel, Ruggero Pardi, Jeffrey R Bender
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201103 (2018)
Activation of the β2 integrin lymphocyte function-associated antigen-1 (LFA-1) in T cells induces stabilization of proinflammatory AU-rich element (ARE)-bearing mRNAs, by triggering the nuclear-to-cytoplasmic translocation of the mRNA-binding and -s
Externí odkaz:
https://doaj.org/article/ad94a9ab4fcd48998eec75084a4ab756
Autor:
Selinda J Orr, Ashley R Burg, Tim Chan, Laura Quigley, Gareth W Jones, Jill W Ford, Deborah Hodge, Catherine Razzook, Joseph Sarhan, Yava L Jones, Gillian C Whittaker, Kimberly C Boelte, Lyudmila Lyakh, Marco Cardone, Geraldine M O'Connor, Cuiyan Tan, Hongchuan Li, Stephen K Anderson, Simon A Jones, Weiguo Zhang, Philip R Taylor, Giorgio Trinchieri, Daniel W McVicar
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003357 (2013)
Fungal pathogens elicit cytokine responses downstream of immunoreceptor tyrosine-based activation motif (ITAM)-coupled or hemiITAM-containing receptors and TLRs. The Linker for Activation of B cells/Non-T cell Activating Linker (LAB/NTAL) encoded by
Externí odkaz:
https://doaj.org/article/144332c55da84330a2dc42ae2982cc57
Autor:
Simon F Roy, Joseph Sarhan, Xinran Liu, Michael J Murphy, Christopher G Bunick, Keith A Choate, William B Damsky, Jennifer M McNiff
Publikováno v:
British Journal of Dermatology. 188:574-576
We report two cases of cutaneous mpox virus infection (formerly known as monkeypox), one of which presented with unusual clinical findings, and demonstrate their histopathological, RNA in situ hybridization (ISH) and ultrastructural characteristics.
Autor:
Vladimir Ilyukha, Alexei Degterev, Wilson M. Connolly, Hayley I. Muendlein, Beiyun C. Liu, Nahum Sonenberg, Jodie R. Pietruska, Alexander Poltorak, Stephen A Schworer, Amy Y. Tang, Irina Smirnova, Joseph Sarhan, Soroush Tahmasebi
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 699-713.e4 (2020)
Cell reports
Cell reports
SUMMARY Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are well known for their capacity to drive necroptosis via mixed-lineage kinase-like domain (MLKL). Recently, RIPK1/3 kinase activity has been shown to drive inflammation via activat
Publikováno v:
Trends in Molecular Medicine. 24:658-668
Most genetic ablations of Interferon (IFN) signaling abolish both the experimentally induced IFN response and constitutive IFN, whose effects are well established in autoimmunity but understudied during infection. In host-pathogen interactions, most
Autor:
Joseph, Sarhan, Beiyun C, Liu, Hayley I, Muendlein, Peng, Li, Rachael, Nilson, Amy Y, Tang, Anthony, Rongvaux, Stephen C, Bunnell, Feng, Shao, Douglas R, Green, Alexander, Poltorak
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(46)
Cell death and inflammation are intimately linked during Yersinia infection. Pathogenic Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ, thereby silencing cytokine expression while activating caspase-8–mediate
Autor:
Douglas R. Green, Alexander Poltorak, Joseph Sarhan, Hayley I. Muendlein, Rachael Nilson, Anthony Rongvaux, Feng Shao, Amy Y. Tang, Peng Li, Stephen C. Bunnell, Beiyun C. Liu
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Cell death and inflammation are intimately linked during Yersinia infection. Pathogenic Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ, thereby silencing cytokine expression while activating caspase-8–mediate
Autor:
Joseph Sarhan, Anar Mikailov
Publikováno v:
Journal of the American Academy of Dermatology. 82:e93