Nucleophilic displacement reactions of 5′-derivatised nucleosides in a vibration ball mill

Autor: Olga Eguaogie, Patrick F. Conlon, Francesco Ravalico, Jamie S. T. Sweet, Thomas B. Elder, Louis P. Conway, Marc E. Lennon, David R. W. Hodgson, Joseph S. Vyle

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 87-92 (2017)

Vibration ball-milling in a zirconia-lined vessel afforded clean and quantitative nucleophilic displacement reactions between 4-methoxybenzylthiolate salts and nucleoside 5′-halides or 5′-tosylates in five to 60 minutes. Under these conditions, c

Externí odkaz: https://doaj.org/article/6d3b6b6007ef41de80e4fea654d64978

Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: a backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography

Autor: Julian Steinhoegl, Olga Eguaogie, Patrick F. Conlon, Christopher J. Law, Jamie S. T. Sweet, Sarah Allman, Jordan J. Wilson, Oliver G. A. Hancox, James H. R. Tucker, Klaudia Englert, Joseph S. Vyle, James P. Hall

Publikováno v: Conlon, P, Eguaogie, O, Wilson, J, Sweet, J, Steinhoegl, J, Englert, K, Hancox, O, Law, C, Allman, S, Tucker, J H R, Hall, J & Vyle, J 2019, ' Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: a backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography ', Chemical Science, vol. 10, pp. 10948-10957 . https://doi.org/10.1039/C9SC04098F

Oligodeoxynucleotides incorporating internucleotide phosphoroselenolate linkages have been prepared under solid-phase synthesis conditions using dimer phosphoramidites. These dimers were constructed following the high yielding Michaelis-Arbuzov (M-A)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bf37a04d1a39a1ef5481f8b8c7ad79
https://centaur.reading.ac.uk/86671/9/c9sc04098f.pdf

Vibration Ball Milling for the Synthesis of 5'-Thioadenosine 5'-Pyrophosphate (P'→5') Adenosine (dASppA)

Autor: Olga Eguaogie, Joseph S. Vyle

Publikováno v: Eguaogie, O & Vyle, J S 2018, ' Vibration Ball Milling for the Synthesis of 5'-Thioadenosine 5'-Pyrophosphate (P'→5') Adenosine (dASppA) ', Current protocols in nucleic acid chemistry, vol. 70, pp. 1.41.1-1.41.12 . https://doi.org/10.1002/cpnc.37
Current Protocols in Nucleic Acid Chemistry

Using vibration ball milling, 5'-chloro-5'-deoxyadenosine (CldA) reacts cleanly with 4-methoxybenzyl mercaptan (MobSH), under basic conditions, to the corresponding thioether (MobSdA), which is isolated following precipitation and trituration. Under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295d03d562aafe76070b739aeb938698
https://pubmed.ncbi.nlm.nih.gov/28921493

Synthesis of novel pyrophosphorothiolate-linked dinucleoside cap analogues in a ball mill

Autor: Francesco Ravalico, Olga Eguaogie, Christopher J. Law, Patricia M. L. Martin, David R. W. Hodgson, Louis P. Conway, Leonie A. Cooke, Joseph S. Vyle

Publikováno v: Eguaogie, O, Cooke, L, Martin, P M L, Ravalico, F, Conway, L P, Hodgson, D R W, Law, C J & Vyle, J S 2016, ' Synthesis of novel pyrophosphorothiolate-linked dinucleoside cap analogues in a ball mill ', Organic and Biomolecular Chemistry, vol. 14, no. 4, pp. 1201–1205 . https://doi.org/10.1039/C5OB02061A
ResearcherID
Organic and biomolecular chemistry, 2016, Vol.14(4), pp.1201-1205 [Peer Reviewed Journal]

Michaelis–Arbuzov reactions of S-aryl disulfide derivatives of 3′-thiothymidine or 5′-thioadenosine with tris(trimethylsilyl) phosphite proceeded in high yields to the corresponding phosphorothiolate monoesters. Subsequent hydrolytic desilylati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9bd784888632395c984227b7008b2b
https://pure.qub.ac.uk/en/publications/synthesis-of-novel-pyrophosphorothiolatelinked-dinucleoside-cap-analogues-in-a-ball-mill(b177e1fb-4489-4f99-91db-d0af7e959dd2).html

Detection of single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer using a fluorophore-tagged DNA probe

Autor: Zheng-yun Zhao, Joseph S. Vyle, James H. R. Tucker, John R. Arrand, Jean-Louis H. A. Duprey, Marie San

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:129-132

Single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer were identified using oligodeoxynucleotide probe sequences bearing internal anthracene fluorophores proximal to the SNP site. Depending upon the nature of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09ba9eeaba115ba1ac3322594743985
https://doi.org/10.1016/j.bmcl.2011.11.053