Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Joseph S. Ostby"'
Autor:
Leon Earl Gray, Joseph S. Ostby, Christy S. Lambright, Andrew K. Hotchkiss, Louise Parks-Saldutti, John G. Vandenbergh
Publikováno v:
Toxicological Sciences. 96:335-345
In mammals, abnormal increases in fetal androgens disrupt normal development of the female phenotype. Due to the recent concern regarding environmental androgen-active chemicals, there is a need to identify sources of fetal androgen variation and sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0eef9d58a885b34999bec4897fa947
https://doi.org/10.1093/toxsci/kfm002
https://doi.org/10.1093/toxsci/kfm002
Publikováno v:
Biology of Reproduction. 72:1324-1335
Prochloraz (PZ) is an imidazole fungicide that displays multiple endocrine activities. It inhibits steroid synthesis via P450 modulation and acts as an androgen receptor (AR) antagonist, but its effects on male sexual differentiation have not been de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1487c2034416a26820c3161391c78018
https://doi.org/10.1095/biolreprod.104.031385
https://doi.org/10.1095/biolreprod.104.031385
Autor:
Christy S. Lambright, Johnathan Furr, L.G. Parks-Saldutti, Joseph S. Ostby, Leon Earl Gray, John G. Vandenbergh, Andrew K. Hotchkiss
Publikováno v:
Biology of Reproduction. 71:1852-1861
Prenatal exposure to environmental chemicals that interfere with the androgen signaling pathway can cause permanent adverse effects on reproductive development in male rats. The objectives of this study were to 1) determine whether a documented antia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04e0a81f8dd2b8754861ff57781ed790
https://doi.org/10.1095/biolreprod.104.031674
https://doi.org/10.1095/biolreprod.104.031674
Autor:
Joseph S. Ostby, Carmen R. Wood, Vickie S. Wilson, Gary A. Held, Christy S. Lambright, L. Earl Gray, Johnathan Furr
Publikováno v:
Toxicology Letters. 146:207-215
Targeted inactivation of the insulin-like hormone 3 (insl3) gene in male mice results in altered gubernacular development, disrupted testis decent, and cryptorchidism. Cryptorchidism is a fairly common human malformation, being displayed in about thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df5d7120c7a28e4ae59742f516afeb5
https://doi.org/10.1016/j.toxlet.2003.09.012
https://doi.org/10.1016/j.toxlet.2003.09.012
Publikováno v:
Physiology & Behavior. 79:151-156
During mammalian sexual differentiation, the androgens, testosterone and dihydrotestosterone are critical for the organization of the male phenotype. In rats, play behavior is sexually dimorphic. Administration of exogenous androgens during the perin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6527784d612e2b808068db70bfcf6683
https://doi.org/10.1016/s0031-9384(03)00093-3
https://doi.org/10.1016/s0031-9384(03)00093-3
Autor:
Cynthia J. Wolf, Leon Earl Gray, Joseph S. Ostby, S.J. Degitz, J.E. Tietge, Ralph L. Cooper, K.M. Jensen, M. Price, Christy S. Lambright, Phillip C. Hartig, Andrew K. Hotchkiss, Tammy E. Stoker, Vickie S. Wilson, E.A. Makynen, J.J. Korte, Johnathan Furr, Kathy Bobseine, M.D. Kahl, Gerald T. Ankley, Louise G. Parks, Susan C. Laws
Publikováno v:
Toxicology. :371-382
The US Environmental Protection Agency (EPA) is developing a screening and testing program for endocrine disrupting chemicals (EDCs) to detect alterations of hypothalamic–pituitary–gonadal (HPG) function, estrogen (ER), androgen (AR) and thyroid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::084fddecf6c24803431163cec9692f41
https://doi.org/10.1016/s0300-483x(02)00469-9
https://doi.org/10.1016/s0300-483x(02)00469-9
Publikováno v:
Toxicological Sciences. 51:259-264
Low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), administered as a single dose to the dam during gestation, alter development of the fetal rodent reproductive system. In male rat and hamster offspring, dosing with TCDD during gestation reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cb5057ca4b499e1d2e273696807b33
https://doi.org/10.1093/toxsci/51.2.259
https://doi.org/10.1093/toxsci/51.2.259
Publikováno v:
Toxicology and Industrial Health. 15:48-64
In humans and rodents, exposure to antiandrogenic chemicals during sexual differentiation can produce malformations of the reproductive tract. Perinatal administration of 100 or 200 mg vinclozolin (V) kg−1 day−1 during sexual differentiation in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd344f25803984827a234da13d7d15c
https://doi.org/10.1177/074823379901500106
https://doi.org/10.1177/074823379901500106
Autor:
Joseph S. Ostby, Ralph L. Cooper, Christy S. Lambright, Matthew Price, Cynthia J. Wolf, L. Earl Gray, Peter C. Mann
Publikováno v:
Toxicology and Industrial Health. 15:94-118
Antiandrogenic chemicals alter sexual differentiation by a variety of mechanisms, and as a consequence, they induce different profiles of effects. For example, in utero treatment with the androgen receptor (AR) antagonist, flutamide, produces ventral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb85f2c14ead3932ab8cdc42874b1c82
https://doi.org/10.1191/074823399678846664
https://doi.org/10.1191/074823399678846664
Publikováno v:
Environmental Toxicology and Chemistry. 17:109-118
Wildlife populations from contaminated ecosystems display a variety of reproductive alterations, including cryptorchidism in the Florida panther, small baculum in young male otters, small penises in alligators, sex reversal in fish, and altered socia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8c89f2c2a50da8b35936bd3a87c1898
https://doi.org/10.1002/etc.5620170113
https://doi.org/10.1002/etc.5620170113