Výsledky vyhledávání - "Joseph S. Mitchell"

The Development of a [211At]-Astatinated Endoradiotherapeutic Drug: Part IV—Late Radiation Effects

Publikováno v: International Journal of Radiation OncologyBiologyPhysics. 40:1177-1183

Purpose: 6-[ 211 At]-astato-MNDP is a high-LET endoradiotherapeutic drug that selectively targets to an oncogenically associated alkaline phosphatase isoenzyme expressed by certain tumors. A detailed histopathological study of the late tissue effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a12179990d9a29d954a95c97efb6bee
https://doi.org/10.1016/s0360-3016(97)00907-3

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The development of a [211at]-astatinated endoradiotherapeutic drug: Part I. Localization by α-particle autoradiography in a murine tumor model

Autor: Ian Brown, R. N. Carpenter, Joseph S. Mitchell

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 23:563-572

α-particle track autoradiography has been used to define the in vivo cellular and intracellular distribution of radioactivity from the potential high linear energy transfer endoradiotherapeutic drug, 6-[ 211 At]-astato-2-methyl-1,4-naphthoquinol bis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10a18b222a03cc378b13b577d93368c
https://doi.org/10.1016/0360-3016(92)90012-7

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The development of a [211At]-astatinated endoradiotherapeutic drug: Part II. Therapeutic results for transplanted adenocarcinoma of the rectum in mice and associated studies

Autor: Joseph S. Mitchell, Ian Brown

Publikováno v: International journal of radiation oncology, biology, physics. 29(1)

Purpose: 6-[ 211 At]-astato-MNDP is of a class of a high linear energy transfer endoradiotherapeutic drug, which selectively targets to an onco -APase isoenzyme expressed by certain epithelial and germ cell tumors. The therapeutic efficacy and acute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f881c61b79f40ca4c52489ed8a49b5
https://pubmed.ncbi.nlm.nih.gov/8175418

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The in vitro selective concentration of an 125I-iodinated compound in human tumor cells

Autor: R. N. Carpenter, Joseph S. Mitchell, B. Chir, Ian Brown

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 9:51-55

Uptake studies of the potential endoradiotherapeutic agent, 6- 125 I-iodo-2-methyl-1,4-naphthoquinoI bis(diammonium phosphate) have been carried out in vitro on a wide range of normal and malignant human cells. In general, for a standardized dose of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a330ff1cca913ea9581643c382bdff
https://doi.org/10.1016/0360-3016(83)90208-0

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α-Particle track autoradiographic study of the distribution of a [211At]-astatinated drug in normal tissues of the mouse

Autor: Joseph S. Mitchell, Ian Brown, R. N. Carpenter

Publikováno v: Experientia. 41:925-928

The microscopic distribution of the potential endoradiotherapeutic drug, 6-[211At]-astato-2-methyl-1,4- naphthoquinol bis (diphosphate salt) in normal tissues of the mouse has been studied by alpha-particle track autoradiography. The uptake into crit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe73f99aae185c5a8f4ab7a06111a04e
https://doi.org/10.1007/bf01970016

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Potential diagnostic and therapeutic agents for malignant melanoma: Synthesis of heavy radiohalogenated derivatives of methylene blue by electrophilic and nucleophilic methods

Autor: R. N. Carpenter, Eva M. Link, Joseph S. Mitchell, Ian Brown

Publikováno v: Journal of Radioanalytical and Nuclear Chemistry Letters. 107:337-351

Heavy radiohalogenated derivatives of methylene blue of potential value as possible diagnostic and endoradiotherapeutic agents for malignant melanoma, have been synthesized by both electrophilic and nucleophilic reaction routes. Thermal halogen isoto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80086a654ae7b0be75db71d07461f6f5
https://doi.org/10.1007/bf02164199

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Biodistribution of 6-[211At]astato-2-methyl-1,4-naphthoquinol bis(diphosphate salt) and 211At− in mice with a transplanted rectal adenocarcinoma

Autor: Joseph S. Mitchell, Ian Brown, R. N. Carpenter

Publikováno v: The International Journal of Applied Radiation and Isotopes. 35:843-847

6-[211At]astato-MNDP is currently being investigated as a potential high LET endoradiotherapeutic drug. Biodistribution and whole-body radiation retention studies have been carried out with 6-[211At]astato-MNDP and 211At− in a murine rectal tumour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0969e578130bd64469131948baa7f086
https://doi.org/10.1016/0020-708x(84)90019-x

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