Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joseph S. Briguglio"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The molecular identity of the clamp that arrests the fusion machinery such that synaptic vesicles are docked and primed to release neurotransmitters remains controversial. In this study, the authors use truncation mutants of synaptotagmin (syt) 1 and
Externí odkaz:
https://doaj.org/article/60a9c376ca40470abac94a203d8f4cc1
Autor:
David A. Ruhl, Ewa Bomba-Warczak, Emma T. Watson, Mazdak M. Bradberry, Tabitha A. Peterson, Trina Basu, Alyssa Frelka, Chantell S. Evans, Joseph S. Briguglio, Tamara Basta, Michael H. B. Stowell, Jeffrey N. Savas, Avtar Roopra, Robert A. Pearce, Robert C. Piper, Edwin R. Chapman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The functional role of synaptotagmin-17 (syt-17) has remained unanswered. In this study, authors demonstrate that syt-17 exists in two distinct pools in hippocampal neurons (Golgi complex and early endosomes), where it served two completely independe
Externí odkaz:
https://doaj.org/article/2285b841eadf401cae3e662ea7ba2f42
Publikováno v:
Molecular biology of the cell. 33(6)
Granule-plasma membrane docking and fusion can only occur when proteins that enable these reactions are present at the granule-plasma membrane contact. Thus, the mobility of granule membrane proteins may influence docking, and membrane fusion. We mea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66d17407f89cb9c3b63561c79d6d291
https://pubmed.ncbi.nlm.nih.gov/34851717
https://pubmed.ncbi.nlm.nih.gov/34851717
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Synaptic vesicle (SV) exocytosis is mediated by SNARE proteins. Reconstituted SNAREs are constitutively active, so a major focus has been to identify fusion clamps that regulate their activity in synapses: the primary candidates are synaptotagmin (sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5626bd386a67b7cd684b84357a68fc
https://doaj.org/article/60a9c376ca40470abac94a203d8f4cc1
https://doaj.org/article/60a9c376ca40470abac94a203d8f4cc1
Although many of the proteins of secretory granules have been identified, little is known about their molecular organization and diffusion characteristics. Granule-plasma membrane fusion can only occur when proteins that enable fusion are present at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7577bc959d8cd6960aae899aad28ec6e
https://doi.org/10.1101/2021.02.20.432015
https://doi.org/10.1101/2021.02.20.432015
Autor:
Yihao Jiang, Huan Bao, Nicholas A. Courtney, Debasis Das, Qiang Cui, Daniel Roston, Xiaochu Lou, Baron Chanda, Joseph S. Briguglio, Edwin R. Chapman
Publikováno v:
Nature. 554:260-263
The fusion pore is the first crucial intermediate formed during exocytosis, yet little is known about the mechanisms that determine the size and kinetic properties of these transient structures. Here, we reduced the number of available SNAREs (protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c605f7746c12c37699f7ccb664f924e7
https://doi.org/10.1038/nature25481
https://doi.org/10.1038/nature25481
Autor:
Avtar Roopra, Robert C. Piper, Michael H. B. Stowell, Tabitha A. Peterson, Chantell S. Evans, Jeffrey N. Savas, Ewa Bomba-Warczak, Robert A. Pearce, Emma T. Watson, Tamara Basta, David A. Ruhl, Trina Basu, Edwin R. Chapman, Alyssa Frelka, Mazdak M. Bradberry, Joseph S. Briguglio
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
The synaptotagmin (syt) proteins have been widely studied for their role in regulating fusion of intracellular vesicles with the plasma membrane. Here we report that syt-17, an unusual isoform of unknown function, plays no role in exocytosis, and ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a6afb6f376eac639a4363ece0f07b4
https://doi.org/10.1038/s41467-019-11459-4
https://doi.org/10.1038/s41467-019-11459-4
Autor:
David A. Ruhl, Robert A. Pearce, Joseph S. Briguglio, Alexander G Figueroa, Edwin R. Chapman, Renhao Xue
Various forms of synaptic plasticity underlie aspects of learning and memory. Synaptic augmentation is a form of short-term plasticity characterized by synaptic enhancement that persists for seconds following specific patterns of stimulation. The mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c8c136e2dc5615965a959ba7f0999d
https://europepmc.org/articles/PMC6004496/
https://europepmc.org/articles/PMC6004496/
Autor:
Edwin R. Chapman, Mazdak M. Bradberry, Joseph S. Briguglio, Nicholas A. Courtney, Christina Greer
Spontaneous neurotransmitter release (mini) is an important form of Ca(2+)-dependent synaptic transmission that occurs in the absence of action potentials. A molecular understanding of this process requires an identification of the underlying Ca(2+)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42489e447c33834cc92e71e8b25e7c4
https://europepmc.org/articles/PMC6090561/
https://europepmc.org/articles/PMC6090561/
Autor:
Timothy Comar, Cynthia D. Huebner, Taha Mirza, Joseph S. Briguglio, Maria Radcliffe, Jeremy Nadolski, Preston R. Aldrich, Enela Aliaj, Jermeen El-Zabet, Seerat Hassan
Publikováno v:
Physica A: Statistical Mechanics and its Applications. 438:32-39
Several studies have shown that human transportation networks exhibit small-world structure, meaning they have high local clustering and are easily traversed. However, some have concluded this without statistical evaluations, and others have compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92476332480066625053095927084915
https://doi.org/10.1016/j.physa.2015.06.013
https://doi.org/10.1016/j.physa.2015.06.013