Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Joseph S. Ainscough"'
Autor:
Thomas Macleod, Joseph S. Ainscough, Christina Hesse, Sebastian Konzok, Armin Braun, Anna-Lena Buhl, Joerg Wenzel, Paul Bowyer, Yutaka Terao, Sarah Herrick, Miriam Wittmann, Martin Stacey
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108515- (2020)
Summary: Epithelial tissues represent vital interfaces between organisms and their environment. As they are constantly exposed to harmful pathogens, innocuous commensals, and environmental microbes, it is essential they sense and elicit appropriate r
Externí odkaz:
https://doaj.org/article/83bec1d408764455abe14e907b7e24a4
Autor:
Martin Stacey, Paul Bowyer, Joerg Wenzel, Miriam Wittmann, Tom Macleod, Sebastian Konzok, Armin Braun, Joseph S. Ainscough, Yutaka Terao, Anna-Lena Buhl, Christina Hesse, Sarah E. Herrick
Publikováno v:
Cell Reports
Cell Reports, Vol 33, Iss 11, Pp 108515-(2020)
Macleod, T, Ainscough, J S, Hesse, C, Konzok, S, Braun, A, Buhl, A-L, Wenzel, J, Bowyer, P, Terao, Y, Herrick, S, Wittmann, M & Stacey, M 2020, ' The Proinflammatory Cytokine IL-36γ Is a Global Discriminator of Harmless Microbes and Invasive Pathogens within Epithelial Tissues ', Cell Reports, vol. 33, no. 11, 108515, pp. 1-12.e3 . https://doi.org/10.1016/j.celrep.2020.108515
Macleod, T, Ainscough, J, Hesse, C, Konzok, S, Braun, A, Buhl, A-L, Wenzel, J, Bowyer, P, Terao, Y, Herrick, S, Wittmann, M & Stacey, M 2020, ' The Proinflammatory Cytokine IL-36γ Is a Global Discriminator of Harmless Microbes and Invasive Pathogens within Epithelial Tissues ', Cell Reports, vol. 33, no. 11, pp. 1-12.e3 . https://doi.org/10.1016/j.celrep.2020.108515
Cell Reports, Vol 33, Iss 11, Pp 108515-(2020)
Macleod, T, Ainscough, J S, Hesse, C, Konzok, S, Braun, A, Buhl, A-L, Wenzel, J, Bowyer, P, Terao, Y, Herrick, S, Wittmann, M & Stacey, M 2020, ' The Proinflammatory Cytokine IL-36γ Is a Global Discriminator of Harmless Microbes and Invasive Pathogens within Epithelial Tissues ', Cell Reports, vol. 33, no. 11, 108515, pp. 1-12.e3 . https://doi.org/10.1016/j.celrep.2020.108515
Macleod, T, Ainscough, J, Hesse, C, Konzok, S, Braun, A, Buhl, A-L, Wenzel, J, Bowyer, P, Terao, Y, Herrick, S, Wittmann, M & Stacey, M 2020, ' The Proinflammatory Cytokine IL-36γ Is a Global Discriminator of Harmless Microbes and Invasive Pathogens within Epithelial Tissues ', Cell Reports, vol. 33, no. 11, pp. 1-12.e3 . https://doi.org/10.1016/j.celrep.2020.108515
Summary Epithelial tissues represent vital interfaces between organisms and their environment. As they are constantly exposed to harmful pathogens, innocuous commensals, and environmental microbes, it is essential they sense and elicit appropriate re
Autor:
David L. Moyes, Julian R. Naglik, Jonathan P. Richardson, Sarah L. Gaffen, Diksha Sihra, J. Ho, Bianca M. Coleman, Felix E. Y. Aggor, Martin Stacey, Akash H. Verma, Olivia W. Hepworth, Joseph S. Ainscough, Bernhard Hube, Hanna Zafar, Nicole O. Ponde, Mandy J. McGeachy
Publikováno v:
The Journal of Immunology. 201:627-634
Protection against microbial infection by the induction of inflammation is a key function of the IL-1 superfamily, including both classical IL-1 and the new IL-36 cytokine families. Candida albicans is a frequent human fungal pathogen causing mucosal
Autor:
Andrew Wright, Martin Stacey, Gordon D. Brown, Tom Macleod, Philip Laws, Miriam Wittmann, Adewonuola Alase, Joerg Wenzel, Anna Berekméri, Joseph S. Ainscough, Philip S. Helliwell, Delyth M. Reid, Mark Goodfield, Anne Latzko, Sara Edward
Publikováno v:
The Journal of Allergy and Clinical Immunology
This project was mainly supported by a 2014 Pfizer Inflammation Competitive Research Programme (ICRP). In addition, assay development support was received by MRC grant MR/M01942X/1. GDB and DMR were funded by the Wellcome Trust (102705, 97377), the M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d7877a6bab9a126c6f27618d5da8cb
https://eprints.whiterose.ac.uk/131520/8/1-s2.0-S0091674918307061-main.pdf
https://eprints.whiterose.ac.uk/131520/8/1-s2.0-S0091674918307061-main.pdf
Autor:
Tom Macleod, Ade Alase, Jens M. Baron, Dennis McGonagle, Miriam Wittmann, Martin Stacey, Rosella Brakefield, Joseph S. Ainscough
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(13)
The pro-inflammatory cytokine IL-36γ is highly expressed in epithelial cells and is a pivotal mediator of epithelial inflammation. In particular, IL-36γ is strongly associated with the inflammatory skin disease psoriasis. As with other IL-1 cytokin
Publikováno v:
Journal of Immunotoxicology. 10:223-234
Allergic contact dermatitis is an important occupational and environmental disease caused by topical exposure to chemical allergens. An area of considerable interest and, in the context of hazard identification and characterization, an area of great
Publikováno v:
The Journal of Biological Chemistry
Ainscough, J, Gerberick, G F, Kimber, I & Dearman, R J 2015, ' Interleukin-1β processing is dependent upon a calcium-mediated interaction with calmodulin. ', The Journal of biological chemistry, vol. 290, no. 52, pp. 31151-31161 . https://doi.org/10.1074/jbc.M115.680694
Ainscough, J, Gerberick, G F, Kimber, I & Dearman, R J 2015, ' Interleukin-1β processing is dependent upon a calcium-mediated interaction with calmodulin. ', The Journal of biological chemistry, vol. 290, no. 52, pp. 31151-31161 . https://doi.org/10.1074/jbc.M115.680694
The secretion of IL-1β is a central event in the initiation of inflammation. Unlike most other cytokines, the secretion of IL-1β requires two signals: one signal to induce the intracellular up-regulation of pro-IL-1β and a second signal to drive s
Autor:
Pavlos C, Englezou, Simon W, Rothwell, Joseph S, Ainscough, David, Brough, Robert, Landsiedel, Alexei, Verkhratsky, Ian, Kimber, Rebecca J, Dearman
Publikováno v:
Cytokine
Highlights • P2X7R-driven IL-1 responses are markedly enhanced in BMDC compared to BMM. • P2X7R antagonist A-740003 inhibitedIL-1 release in BMDC and BMM. • P2X7R-induced pore formation was greater in BMDC than in BMM. • LPS-primed BMDC resis
Autor:
Rebecca J. Dearman, Ian Kimber, Gloria Lopez-Castejon, Maryam Zahedi-Nejad, David Brough, Joseph S. Ainscough, G. Frank Gerberick
Publikováno v:
The Journal of Biological Chemistry
Background: Interleukin-1 secretion is an important process in inflammation and thus, the intracellular regulation of these cytokines is of interest. Results: Inhibition of the proteasome in dendritic cells inhibits interleukin-1 degradation and lead
Publikováno v:
Journal of Investigative Dermatology. 136:S226