Zobrazeno 1 - 10
of 248
pro vyhledávání: '"Joseph S. Beckman"'
Autor:
James B. W. Hilton, Kai Kysenius, Jeffrey R. Liddell, Stephen W. Mercer, Bence Paul, Joseph S. Beckman, Catriona A. McLean, Anthony R. White, Paul S. Donnelly, Ashley I. Bush, Dominic J. Hare, Blaine R. Roberts, Peter J. Crouch
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The copper compound CuII(atsm) has progressed to phase 2/3 testing for treatment of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). CuII(atsm) is neuroprotective in mutant SOD1 mouse models of ALS where its activity is asc
Externí odkaz:
https://doaj.org/article/236516f7a4ca40819c0aeb1e8d9cbdfc
Autor:
Jeffrey R. Liddell, James B. W. Hilton, Kai Kysenius, Jessica L. Billings, Sara Nikseresht, Lachlan E. McInnes, Dominic J. Hare, Bence Paul, Stephen W. Mercer, Abdel A. Belaidi, Scott Ayton, Blaine R. Roberts, Joseph S. Beckman, Catriona A. McLean, Anthony R. White, Paul S. Donnelly, Ashley I. Bush, Peter J. Crouch
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-21 (2024)
Abstract Background Ferroptosis is a form of regulated cell death characterised by lipid peroxidation as the terminal endpoint and a requirement for iron. Although it protects against cancer and infection, ferroptosis is also implicated in causing ne
Externí odkaz:
https://doaj.org/article/c1c1ef71cd304efcb8d9a959888a9cd7
Autor:
Shay Vimer, Gili Ben-Nissan, David Morgenstern, Fanindra Kumar-Deshmukh, Caley Polkinghorn, Royston S. Quintyn, Yury V. Vasil’ev, Joseph S. Beckman, Nadav Elad, Vicki H. Wysocki, Michal Sharon
Publikováno v:
ACS Central Science, Vol 6, Iss 4, Pp 573-588 (2020)
Externí odkaz:
https://doaj.org/article/fc82531319674d8e8935501609c8c817
Autor:
Phillip Zhu, Stanislau Stanisheuski, Rachel Franklin, Amber Vogel, Cat Hoang Vesely, Patrick Reardon, Nikolai N. Sluchanko, Joseph S. Beckman, P. Andrew Karplus, Ryan A. Mehl, Richard B. Cooley
Publikováno v:
ACS Central Science. 9:816-835
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::735c8f2c6744e63b8ade649081062c56
https://doi.org/10.1021/acscentsci.3c00191
https://doi.org/10.1021/acscentsci.3c00191
Publikováno v:
Neurobiology of Disease, Vol 130, Iss , Pp 104495- (2019)
CuATSM is a PET-imaging agent that has recently received attention for its success in extending the lifespan in animals in several neurodegenerative disease models. In the SOD1G93A model of ALS, CuATSM prolonged mouse longevity far longer than any pr
Externí odkaz:
https://doaj.org/article/50f67288efd045359c01b8ccc0e7e642
Autor:
Emiliano Trias, Pamela R. Beilby, Mariángeles Kovacs, Sofía Ibarburu, Valentina Varela, Romina Barreto-Núñez, Samuel C. Bradford, Joseph S. Beckman, Luis Barbeito
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Age is a recognized risk factor for amyotrophic lateral sclerosis (ALS), a paralytic disease characterized by progressive loss of motor neurons and neuroinflammation. A hallmark of aging is the accumulation of senescent cells. Yet, the pathogenic rol
Externí odkaz:
https://doaj.org/article/24663bf2e9884539badf6024476304e9
Autor:
Jared R. Williams, Emiliano Trias, Pamela R. Beilby, Nathan I. Lopez, Edwin M. Labut, C. Samuel Bradford, Blaine R. Roberts, Erin J. McAllum, Peter J. Crouch, Timothy W. Rhoads, Cliff Pereira, Marjatta Son, Jeffrey L. Elliott, Maria Clara Franco, Alvaro G. Estévez, Luis Barbeito, Joseph S. Beckman
Publikováno v:
Neurobiology of Disease, Vol 89, Iss , Pp 1-9 (2016)
Over-expression of mutant copper, zinc superoxide dismutase (SOD) in mice induces ALS and has become the most widely used model of neurodegeneration. However, no pharmaceutical agent in 20 years has extended lifespan by more than a few weeks. The Cop
Externí odkaz:
https://doaj.org/article/317f96cedfe543dcbf44df3fa341418c
Publikováno v:
Free Radical Biology and Medicine. 178:330-346
Mitochondria serve vital roles critical for overall cellular function outside of energy transduction. Thus, mitochondrial decay is postulated to be a key factor in aging and in age-related diseases. Mitochondria may be targets of their own decay thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0244c78e6e61bff034ff5f98d9b8329b
https://doi.org/10.1016/j.freeradbiomed.2021.12.008
https://doi.org/10.1016/j.freeradbiomed.2021.12.008
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2500
Localizing metal binding to specific sites in proteins remains a challenging analytical problem in vitro and in vivo. Although metal binding can be maintained by "native" electrospray ionization with intact proteins for quantitation by mass spectrome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c68aadcd52d132893de75fcfb0239cd4
https://pubmed.ncbi.nlm.nih.gov/35657595
https://pubmed.ncbi.nlm.nih.gov/35657595
Autor:
Valery G. Voinov, Michael Hare, George Stafford, Jared B. Shaw, Yury V. Vasil’ev, Derrill Sturgeon, Cody Schwarzer, Christian Klein, Rebecca Glaskin, Joseph S. Beckman, Shuai Wu, Diana Oppenheimer
Publikováno v:
Journal of the American Society for Mass Spectrometry
Electron-based dissociation (ExD) produces uncluttered mass spectra of intact proteins while preserving labile post-translational modifications. However, technical challenges have limited this option to only a few high-end mass spectrometers. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94fb157017229d6319017cab94f6ee6
https://doi.org/10.1021/jasms.0c00482
https://doi.org/10.1021/jasms.0c00482