Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Joseph S Snowden"'
Autor:
Joseph S Snowden, Daniel L Hurdiss, Oluwapelumi O Adeyemi, Neil A Ranson, Morgan R Herod, Nicola J Stonehouse
Publikováno v:
PLoS Biology, Vol 18, Iss 3, p e3000649 (2020)
Icosahedral viral capsids must undergo conformational rearrangements to coordinate essential processes during the viral life cycle. Capturing such conformational flexibility has been technically challenging yet could be key for developing rational th
Externí odkaz:
https://doaj.org/article/9d3e1b9c3f2e493eb9f7b4ef1bc203d2
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1005955 (2016)
The type I interferon (IFN) response is a crucial innate immune signalling pathway required for defense against viral infection. Accordingly, the great majority of mammalian viruses possess means to inhibit this important host immune response. Here w
Externí odkaz:
https://doaj.org/article/14e0e834f7734b31bf827723548285fa
Autor:
Natalie J. Kingston, Keith Grehan, Joseph S. Snowden, Mark Hassall, Jehad Alzahrani, Guido C. Paesen, Lee Sherry, Connor Hayward, Amy Roe, Sam Stephen, Darren Tomlinson, Antra Zeltina, Katie J. Doores, Neil A. Ranson, Martin Stacey, Mark Page, Nicola J. Rose, Thomas A. Bowden, David J. Rowlands, Nicola J. Stonehouse
Publikováno v:
mSphere, Vol 8, Iss 1 (2023)
ABSTRACT Having varied approaches to the design and manufacture of vaccines is critical in being able to respond to worldwide needs and newly emerging pathogens. Virus-like particles (VLPs) form the basis of two of the most successful licensed vaccin
Externí odkaz:
https://doaj.org/article/b7c301ef9e3a4446bd7a97505024123b
Autor:
Jake T. Mills, Susanna C. Minogue, Joseph S. Snowden, Wynter K.C. Arden, David J. Rowlands, Nicola J. Stonehouse, Christiane E. Wobus, Morgan R. Herod
Publikováno v:
bioRxiv
Viruses interact with receptors on the cell surface to initiate and co-ordinate infection. The distribution of receptors on host cells can be a key determinant of viral tropism and host infection. Unravelling the complex nature of virus-receptor inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0248f9ff41366452b188f983fe434c80
https://europepmc.org/articles/PMC9949111/
https://europepmc.org/articles/PMC9949111/
Autor:
Natalie J Kingston, Joseph S Snowden, Agnieszka Martyna, Mona Shegdar, Keith Grehan, Alison Tedcastle, Elaine Pegg, Helen Fox, Andrew J Macadam, Javier Martin, James M Hogle, David J Rowlands, Nicola J Stonehouse
Enterovirus A71 (EVA71) causes widespread disease in young children with occasional fatal consequences. In common with other picornaviruses, both empty capsids (ECs) and infectious virions are produced during the viral lifecycle. While initially anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb6b0829e1b634e1f8b5dad2afac80f5
https://doi.org/10.1101/2023.01.30.526315
https://doi.org/10.1101/2023.01.30.526315
Autor:
Natalie J. Kingston, Mona Shegdar, Joseph S. Snowden, Helen Fox, Elisabetta Groppelli, Andrew Macadam, David J. Rowlands, Nicola J. Stonehouse
Publikováno v:
The Journal of general virology. 103(8)
Enterovirus A71 (EVA71) infection can result in paralysis and may be fatal. In common with other picornaviruses, empty capsids are produced alongside infectious virions during the viral lifecycle. These empty capsids are antigenically indistinguishab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be8bbae3ba4a0d454f4b9d317cb7a2a
https://pubmed.ncbi.nlm.nih.gov/35997623
https://pubmed.ncbi.nlm.nih.gov/35997623
Autor:
Natalie J. Kingston, Keith Grehan, Joseph S. Snowden, Mona Shegdar, Helen Fox, Andrew J. Macadam, David J. Rowlands, Nicola J. Stonehouse
Publikováno v:
mSphere. 7(3)
Enterovirus A71 (EVA71) is a medically important virus that is commonly associated with hand, foot, and mouth disease (HFMD). It is responsible for periodic outbreaks, resulting in significant economic impact and loss of life. Vaccination offers the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b30bd9d9001e7b8a771aa67c5b41660
https://pubmed.ncbi.nlm.nih.gov/35642505
https://pubmed.ncbi.nlm.nih.gov/35642505
Autor:
Natalie J Kingston, Keith Grehan, Joseph S Snowden, Mark Hassall, Jehad Alzahrani, Guido C Paesen, Lee Sherry, Connor Hayward, Amy Roe, Sam Stephen, Darren Tomlinson, Antra Zeltina, Katie J Doores, Neil A Ranson, Martin Stacey, Mark Page, Nicola J Rose, Thomas A Bowden, David J Rowlands, Nicola J Stonehouse
Having varied approaches to the design and manufacture of vaccines is critical in being able to respond to worldwide needs and to newly emerging pathogens. Virus-like particle (VLP) vaccines form the basis of two of the most successful licensed vacci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0345f2318ac7709ebb7dabbc45162e8e
https://doi.org/10.1101/2022.04.22.489148
https://doi.org/10.1101/2022.04.22.489148
Autor:
Callum Talbot-Cooper, Yongxu Lu, Liane Dupont, Brian J. P. Huntly, Geoffrey L. Smith, Jennifer H. Stuart, Shuchi Agrawal-Singh, Joseph S. Snowden, Andrei I. Smid
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Histone deacetylases (HDACs) are regulators of host gene expression. HDAC4 is shown here to have an important role in type I interferon (IFN) signaling. Here, multiple cell lines lacking HDAC4 had impaired responses to IFN-α and were re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18abd67d3939b3fe8a1323591374e449
https://doi.org/10.1073/pnas.1816399116
https://doi.org/10.1073/pnas.1816399116
Autor:
David J. Rowlands, Martin Stacey, Joseph S. Snowden, Neil A. Ranson, Lee Sherry, Jehad Alzahrani, Nicola J. Stonehouse
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Type I fatty acid synthases (FASs) are critical metabolic enzymes which are common targets for bioengineering in the production of biofuels and other products. Serendipitously, we identified FAS as a contaminant in a cryoEM dataset of virus-like part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac685bad930a375c12726f501936d8ed
http://europepmc.org/articles/PMC8105331
http://europepmc.org/articles/PMC8105331