Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Joseph Rucker"'
Autor:
Kelly Byrnes-Blake, Kate Slovik, Joseph Rucker, Ileine Sanchez, Kyle Doolan, Breanna Tyrell, Anna Lobley, Nicholas Molino, Kristin Shema, Kyle Guldner, Hayley Roth, Alyssa Cunningham, Eric Butz, Stanley Roberts, Riley Payne, Ed Calamai, Ross Chambers
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/eaa8b95d0cde48acbfa27244651580da
Autor:
Benjamin Doranz, Joseph Rucker, Ileine Sanchez, Kyle Doolan, Breanna Tyrell, Anna Lobley, Hayley Roth, Alyssa Cunningham, Ross Chambers, Trevor Barnes, Nnenna Nwogu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/40d96e55d97a4795a515ad0e11fa65f1
Autor:
Melissa A Edeling, S Kyle Austin, Bimmi Shrestha, Kimberly A Dowd, Swati Mukherjee, Christopher A Nelson, Syd Johnson, Manu N Mabila, Elizabeth A Christian, Joseph Rucker, Theodore C Pierson, Michael S Diamond, Daved H Fremont
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004072 (2014)
We recently described our most potently neutralizing monoclonal antibody, E106, which protected against lethal Dengue virus type 1 (DENV-1) infection in mice. To further understand its functional properties, we determined the crystal structure of E10
Externí odkaz:
https://doaj.org/article/2e886409b57a4c2e80d053bbf06bccf9
Autor:
Joseph Rucker, Rachel H. Fong, Tabb Sullivan, Carmen Navia, Brad Screnci, Rona Wilf, Benjamin J. Doranz
Publikováno v:
Cancer Research. 83:2646-2646
Rigorous specificity analysis is critical for the development of antibody-based therapies, as even minimal off-target binding can lead to toxicity and clinical failures. Long believed to be exquisitely specific, recent preclinical data and our own wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdec5dca593a7da126c4c78ab976761d
https://doi.org/10.1158/1538-7445.am2023-2646
https://doi.org/10.1158/1538-7445.am2023-2646
Autor:
Joseph Rucker, Kyle Doolan, Breanna Tyrell, Anna Lobley, Nick Molino, Kristen Shema, Kyle Guldner, Alyssa Cunningham, Ross Chambers, Riley Payne
Publikováno v:
Cancer Research. 82:2892-2892
There is growing interest in applying antibody modalities including bispecifics, antibody-drug conjugates, and CART to solid tumors. However, identifying appropriate tumor-specific targets that avoid adverse effects in healthy tissue has been challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::031701fdbee10d5213bf9150b199a04a
https://doi.org/10.1158/1538-7445.am2022-2892
https://doi.org/10.1158/1538-7445.am2022-2892
Autor:
Sean Deacon, Martin Stogniew, Joshua E. Allen, Caroline A. Cuoco, R. Benjamin Free, Joseph Rucker, Varun V. Prabhu, David R. Sibley, Chidananda Sulli, Lakshmi Anantharaman, Wolfgang Oster, Benjamin J. Doranz, Marilyn M. Day, Edgar Davidson, J. Robert Lane, Neil Charter, Blair K. A. Willette
Publikováno v:
Neuro Oncol
ONC201 has exhibited durable tumor regressions in midline high grade glioma patients. G protein-coupled receptor (GPCR) dopamine receptor D2 (DRD2) is overexpressed in high grade gliomas, controls several oncogenic mechanisms, and its antagonism caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c41d688770375ff704a83407a6fd1d
https://europepmc.org/articles/PMC6847112/
https://europepmc.org/articles/PMC6847112/
Autor:
Caroline A. Cuoco, Mark R. Gilbert, Varun V. Prabhu, Neil Charter, Lakshmi Anantharaman, Blair K. A. Willette, Jinkyu Jung, Abed Rahman Kawakibi, R. Benjamin Free, Benjamin J. Doranz, Martin Stogniew, Joshua E. Allen, Wolfgang Oster, Joseph Rucker, David R. Sibley, Marilyn M. Day
Publikováno v:
Neuro Oncol
ONC201 is the first bitopic antagonist of dopamine receptor D2 (DRD2) in oncology clinical trials, which have shown that the small molecule is well tolerated and induces durable tumor regressions in H3 K27M-mutant glioma patients. ONC201 possesses a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8452f35618af80dff5922e2f235ec552
https://europepmc.org/articles/PMC6846870/
https://europepmc.org/articles/PMC6846870/
Autor:
Nicholas Molino, Chidananda Sulli, Benjamin J. Doranz, Lewis J. Stafford, Erin Rosenberg, Tom Charpentier, Ross Chambers, David F. Tucker, Joseph Rucker, Brad Screnci
Publikováno v:
Diabetes. 68
Integral membrane proteins are important drug targets, and monoclonal antibodies (mAbs) against them are highly sought for therapeutic and diagnostic purposes. However, the complex structure of multipass membrane proteins makes discovery of these mAb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1caa2784f51922aa6c0b4e56b2e766b
https://doi.org/10.2337/db19-1177-p
https://doi.org/10.2337/db19-1177-p
Autor:
Tracy M. Handel, Melanie P. Wescott, Irina Kufareva, Jason R. Goodman, Bridget A. Puffer, Cheryl Paes, Yana Thaker, Eli Berdougo, Benjamin J. Doranz, Joseph Rucker
Publikováno v:
Proceedings of the National Academy of Sciences. 113:9928-9933
The atomic-level mechanisms by which G protein-coupled receptors (GPCRs) transmit extracellular ligand binding events through their transmembrane helices to activate intracellular G proteins remain unclear. Using a comprehensive library of mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985bcf54c2372a63a27787f2ed51356b
https://doi.org/10.1073/pnas.1601278113
https://doi.org/10.1073/pnas.1601278113
Autor:
Ellen J. Collarini, Lucia Lopalco, Minha Park, Stephanie Varela, Rob Etches, Harriman William Don, Shelley Izquierdo, Joseph Rucker, Daniel R. Lu, Shreya Pramanick
Publikováno v:
Microscopy
The analysis of secreted antibody from large and diverse populations of B cells in parallel at the clonal level can reveal desirable antibodies for diagnostic or therapeutic applications. By immobilizing B cells in microdroplets with particulate repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be526c83301c5f057430781ba0d5927f
https://doi.org/10.1093/jmicro/dfw014
https://doi.org/10.1093/jmicro/dfw014