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of 5
pro vyhledávání: '"Joseph Robert Burgoyne"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Histone crotonylation is a newly identified epigenetic modification that has a pronounced ability to regulate gene expression. It belongs to an expanding group of short chain lysine acylations that also includes the extensively studied mark histone a
Externí odkaz:
https://doaj.org/article/eabcafc76daa40d38470c9eba37499d3
Autor:
Hyun-Ju Cho, Christopher Harry Switzer, Alisa Kamynina, Rebecca Charles, Olena Rudyk, Tony Ng, Joseph Robert Burgoyne, Philip Eaton
Publikováno v:
Redox Biology, Vol 29, Iss , Pp - (2020)
Nitro-oleate (10-nitro-octadec-9-enoic acid), which inhibits soluble epoxide hydrolase (sEH) by covalently adducting to C521, increases the abundance of epoxyeicosatrienoic acids (EETs) that can be health promoting, for example by lowering blood pres
Externí odkaz:
https://doaj.org/article/661d433630a3446990b74330d9bfc1b2
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
A dysfunction of autophagy can be detected in aged tissues, but how this is regulated is unclear. Here, the authors show in vitro and in aged mice aorta, that inhibition of LC3 lipidation under conditions of oxidative stress causes oxidation of Atg3
Externí odkaz:
https://doaj.org/article/8e8eefa46f644e3e88874424709de09f
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
Homeostatic cardiac function is maintained by a complex network of interdependent signaling pathways which become compromised during disease progression. Excitation-contraction-coupling, the translation of an electrical signal to a contractile respon
Externí odkaz:
https://doaj.org/article/a4953833b23d4fcdb348c1ef543c4a03
Autor:
Joseph Robert, Burgoyne, Philip, Eaton
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1020
cGMP-dependent protein kinase, also known as protein kinase G (PKG), is activated independently of cGMP by a novel thiol-reactive mechanism involving the formation of an intermolecular disulfide. This oxidative modification within PKG is generally no