Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Joseph Raybon"'
Autor:
Jeremy H. Toyn, Lorin A. Thompson, Kimberley A. Lentz, Jere E. Meredith, Catherine R. Burton, Sethu Sankaranararyanan, Valerie Guss, Tracey Hall, Lawrence G. Iben, Carol M. Krause, Rudy Krause, Xu-Alan Lin, Maria Pierdomenico, Craig Polson, Alan S. Robertson, R. Rex Denton, James E. Grace, John Morrison, Joseph Raybon, Xiaoliang Zhuo, Kimberly Snow, Ramesh Padmanabha, Michele Agler, Kim Esposito, David Harden, Margaret Prack, Sam Varma, Victoria Wong, Yingjie Zhu, Tatyana Zvyaga, Samuel Gerritz, Lawrence R. Marcin, Mendi A. Higgins, Jianliang Shi, Cong Wei, Joseph L. Cantone, Dieter M. Drexler, John E. Macor, Richard E. Olson, Michael K. Ahlijanian, Charles F. Albright
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2014 (2014)
Alzheimer’s disease is the most prevalent cause of dementia and is associated with accumulation of amyloid-β peptide (Aβ), particularly the 42-amino acid Aβ1-42, in the brain. Aβ1-42 levels can be decreased by γ-secretase modulators (GSM), whi
Externí odkaz:
https://doaj.org/article/1dce320132d4411583a19dcbfe2b54ae
Autor:
Katherine A. Grant-Young, Andrew Nickel, Rajesh Onkardas Bora, Prakash Anjanappa, Bender John A, Kevin Kish, Kap-Sun Yeung, Dawn D. Parker, Joseph Raybon, Mark R. Witmer, Karen Rigat, Matthew G. Soars, Steven Sheriff, Yue-Zhong Shu, Kenneth S. Santone, Prashantha Gunaga, Kyle Parcella, Nicholas A. Meanwell, Jay O. Knipe, Susan B. Roberts, Alicia Ng, Michael Sinz, Kathy Mosure, Ying-Kai Wang, Brett R. Beno, Mengping Liu, Elizabeth Colston, Dennis M. Grasela, John F. Kadow, Qi Gao, Min Gao, Umesh Hanumegowda, Roy Haskell, Julie A. Lemm, Xiaoliang Zhuo, Changhong Wan, Kumaravel Selvakumar
Publikováno v:
Journal of Medicinal Chemistry. 60:4369-4385
The hepatitis C virus (HCV) NS5B replicase is a prime target for the development of direct-acting antiviral drugs for the treatment of chronic HCV infection. Inspired by the overlay of bound structures of three structurally distinct NS5B palm site al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e500f8c2cd73d6873f1280c193d753
https://doi.org/10.1021/acs.jmedchem.7b00328
https://doi.org/10.1021/acs.jmedchem.7b00328
Autor:
Amy Newton, Joanna Hu, Thorsten Rosner, George O. Tora, Yu-Wen Li, Joseph Raybon, Yi Hsiao, Xiaoping Hou, Joanne J. Bronson, Nicholas J. Lodge, John E. Macor, David A. Conlon, Carl D. Davis, Jung-Hui Sun, Michael K. Wong, Kevin W. Gillman, Sarah J. Taylor, Umesh Hanumegowda, Rudolph G. Krause, Huiping Zhang, Hong Huang, Matthew T. Taber, Andrew P. Degnan, Rick L. Pieschl
Publikováno v:
ACS Chemical Neuroscience. 7:1635-1640
Combination studies of neurokinin 1 (NK1) receptor antagonists and serotonin-selective reuptake inhibitors (SSRIs) have shown promise in preclinical models of depression. Such a combination may offer important advantages over the current standard of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6fa37d587f9db97c4c47bad7b33ffb
https://doi.org/10.1021/acschemneuro.6b00337
https://doi.org/10.1021/acschemneuro.6b00337
Autor:
John Morrison, Kenneth M. Boy, Alan S. Robertson, Malaz AbuTarif, Jeremy H. Toyn, Valerie Guss, Xiaoliang Zhuo, Maciej Gasior, James E. Grace, Cong Wei, Jun-Sheng Wang, Quan Hong, Joseph Raybon, Lynda S. Cook, Nina Hoque, Richard E. Olson, Wendy Clarke, Rex Denton, Lorin A. Thompson, Francis Sweeney, Flora Berisha, Jere E. Meredith, Dieter M. Drexler, Holly Soares, Kimberly A. Lentz, Charlie F. Albright, Ramesh Padmanabha, Michael J. Furlong, John E. Macor, Michael K. Ahlijanian, Dmitry Zuev, Kimberly Snow
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
The amyloid-β peptide (Aβ)-in particular, the 42-amino acid form, Aβ1-42-is thought to play a key role in the pathogenesis of Alzheimer's disease (AD). Thus, several therapeutic modalities aiming to inhibit Aβ synthesis or increase the clearance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c27817650721b910af7d1d2e922680b
https://doi.org/10.1124/jpet.116.232249
https://doi.org/10.1124/jpet.116.232249
Autor:
Matt Pokross, Jonathan Lippy, Guanglin Luo, Vinod Arora, Hong Xiao, Nengyin Liu, John E. Macor, Joseph Raybon, Wendy Clarke, Catherine R. Burton, David R. Langley, Carol M. Krause, Gene M. Dubowchik, Yang Cao, Ling Chen, Hal A. Lewis, Kimberly Snow, Prasanna Sivaprakasam, Kevin Kish
Publikováno v:
Journal of Medicinal Chemistry. 59:1041-1051
GSK-3 is a serine/threonine kinase that has numerous substrates. Many of these proteins are involved in the regulation of diverse cellular functions, including metabolism, differentiation, proliferation, and apoptosis. Inhibition of GSK-3 may be usef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6b7565032e7ab38f139d202ec3bbb6
https://doi.org/10.1021/acs.jmedchem.5b01550
https://doi.org/10.1021/acs.jmedchem.5b01550
Autor:
Majid Vakilynejad, Arijit Chakravarty, Tonika Bohnert, Anu Shilpa Krishnatry, Jerome T. Mettetal, Tristan S. Maurer, Christopher R. Gibson, Daniel R. Mudra, Edgar Schuck, Yaming Su, Marjoleen J.M.A Nijsen, Tycho Heimbach, Shining Wang, Virna J A Schuck, Cheng-Pang Hsu, Harvey Wong, Patrick Trapa, Joseph Raybon, Patricia Schroeder, Satyendra Suryawanshi, Jing Lin, Bianca M. Liederer, Valeriu Damian-Iordache, Alice Tsai
Publikováno v:
The AAPS Journal. 17:462-473
The application of modeling and simulation techniques is increasingly common in preclinical stages of the drug discovery and development process. A survey focusing on preclinical pharmacokinetic/pharmacodynamics (PK/PD) analysis was conducted across
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987c55984d67b4b816af57121c982893
https://doi.org/10.1208/s12248-014-9716-2
https://doi.org/10.1208/s12248-014-9716-2
Autor:
Michael K. Ahlijanian, Joseph Raybon, Jun-Sheng Wang, Richard E. Olson, Holly Soares, Robert M. Berman, Dieter M. Drexler, Quan Hong, Flora Berisha, Kimberley A. Lentz, Billy Akinsanya, Malaz AbuTarif, John Morrison, John E. Macor, Jeremy H. Toyn, Naiyu Zheng, Maciej Gasior, Michael T. Furlong, Lorin A. Thompson, Francis J. Sweeney, Charlie F. Albright
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
The pharmacokinetics, pharmacodynamics, safety, and tolerability of BMS-932481, a γ-secretase modulator (GSM), were tested in healthy young and elderly volunteers after single and multiple doses. BMS-932481 was orally absorbed, showed dose proportio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9f5f583fd8b029e4b384a20801f0c4
https://pubmed.ncbi.nlm.nih.gov/27189973
https://pubmed.ncbi.nlm.nih.gov/27189973
Autor:
Ramesh Padmanabha, Samuel Gerritz, Lorin A. Thompson, Joseph L. Cantone, Michele Agler, Dieter M. Drexler, Tracey Hall, David G. Harden, Rudy Krause, Charles F. Albright, Tatyana Zvyaga, Xiaoliang Zhuo, Victoria Wong, Jianliang Shi, Craig Polson, James E. Grace, Jeremy H. Toyn, Kim Esposito, Kimberly Snow, Valerie Guss, Maria Pierdomenico, John Morrison, Lawrence R. Marcin, Sam Varma, Jere E. Meredith, Cong Wei, Sethu Sankaranararyanan, John E. Macor, Mendi A. Higgins, Kimberley A. Lentz, Xu-Alan Lin, Joseph Raybon, Carol M. Krause, Michael K. Ahlijanian, Margaret M. Prack, Catherine R. Burton, Lawrence G. Iben, Richard E. Olson, Alan S. Robertson, Rex Denton, Yingjie Zhu
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2014 (2014)
International Journal of Alzheimer's Disease
International Journal of Alzheimer's Disease
Alzheimer’s disease is the most prevalent cause of dementia and is associated with accumulation of amyloid-βpeptide (Aβ), particularly the 42-amino acid Aβ1-42, in the brain. Aβ1-42 levels can be decreased byγ-secretase modulators (GSM), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a200c84c75814b878131607c3b7c2d
Publikováno v:
Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12a3adc5189a2d3a04cb1114ac658fea
https://doi.org/10.1002/9781118354483.ch4
https://doi.org/10.1002/9781118354483.ch4
Autor:
Donna M. Barten, Valerie Guss, Gary Pilcher, Kimberley A. Lentz, Kevin W. Gillman, Joseph Raybon, John E. Macor, Paul Rhyne, Vlad Coric, Lorna Castaneda, John G. Houston, Jeremy H. Toyn, Jun-Sheng Wang, Robert Zaczek, Howard Feldman, Robert M. Berman, Frank J. Simutis, Jere E. Meredith, Gary Tong, Charles F. Albright, Craig Polson, Thomas P. Sanderson, Joanne J. Bronson, Catherine R. Burton, Sethu Sankaranarayanan, Oleksandr Sverdlov, Randy White, Randy C. Dockens, John E. Starrett, Randy Slemmon, Shu-Pang Huang, Richard E. Olson, Rex Denton
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 344(3)
A hallmark of Alzheimer's disease (AD) pathology is the accumulation of brain amyloid β-peptide (Aβ), generated by γ-secretase-mediated cleavage of the amyloid precursor protein (APP). Therefore, γ-secretase inhibitors (GSIs) may lower brain Aβ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf75c2695cab36ae969768516aeb875c
https://pubmed.ncbi.nlm.nih.gov/23275065
https://pubmed.ncbi.nlm.nih.gov/23275065