Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joseph Ramcharan"'
Publikováno v:
Methods. 47:243-248
Oligonucleotide assays have been invaluable for elucidation of the molecular mechanisms of retroviral integrases. A suite of rapid and sensitive fluorescence assays to measure the DNA binding, processing, and joining activities of integrase (IN) is d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b995660bb495bd281212f3c227430b
https://doi.org/10.1016/j.ymeth.2008.10.024
https://doi.org/10.1016/j.ymeth.2008.10.024
Autor:
Joseph Ramcharan, Anna Marie Skalka
Publikováno v:
Future Virology. 1:717-731
HIV-1 integrase, which catalyzes the joining of viral DNA to the host cell DNA, has attracted considerable attention as a target for the design and screening of novel anti-HIV drugs as it is essential for virus replication and the establishment of pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad4cfaf1c5efa119ee0a6c79fffa476b
https://doi.org/10.2217/17460794.1.6.717
https://doi.org/10.2217/17460794.1.6.717
Autor:
Marc A. Labroli, G. Peter Beardsley, Thomas H. Marsilje, Stephen J. Baker, Joel Desharnais, Ali Tavassoli, Joseph Ramcharan, Michael P. Hedrick, Yan Zhang, Stephen J. Benkovic, Lata T. Gooljarsingh, Ian A. Wilson, Dale L. Boger, Qing Jin
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:2739-2749
The synthesis of 10-formyl-DDACTHF (3) as a potential inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase) is reported. Aldehyde 3, the corresponding gamma- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab0040ee427018bd1a971fa3dc0e170c
https://doi.org/10.1016/s0968-0896(02)00102-5
https://doi.org/10.1016/s0968-0896(02)00102-5
Autor:
Patricia A. Horton, Ian A. Wilson, Stephen J. Benkovic, S.E. Greasley, Joseph Ramcharan, G.P. Beardsley
Publikováno v:
Nature Structural Biology. 8:402-406
Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afb8ff084c2a2d00839890bfca54dc4e
https://doi.org/10.1038/87555
https://doi.org/10.1038/87555
Autor:
Ariane E. Marolewski, Paul A. Kitos, Dale L. Boger, Joseph Ramcharan, Nancy-Ellen Haynes, Mark S. Warren, Stephen J. Benkovic
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:1817-1830
The synthesis of 10-formyl-5,8,10-trideazafolic acid (3) as a potential inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) is reported. The target compound was prepared by a convergent synthesis utilizing the alkylation of hydrazone 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801564b7c66ebceeb7b44a19dcdf6271
https://doi.org/10.1016/s0968-0896(97)00120-x
https://doi.org/10.1016/s0968-0896(97)00120-x
Autor:
Joseph Ramcharan, Stephen J. Benkovic, Mark S. Warren, Paul A. Kitos, Lata T. Gooljarsingh, Nancy-Ellen Haynes, Dale L. Boger
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:1831-1838
A series of TDAF-based analogues of 10-formyl-tetrahydrofolic acid are examined in efforts to explore the formyl transfer region of GAR Tfase and AICAR Tfase.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9deb241e33a823c08832a2cc74b8f04d
https://doi.org/10.1016/s0968-0896(97)00121-1
https://doi.org/10.1016/s0968-0896(97)00121-1
Autor:
Mark S. Warren, Joseph Ramcharan, Nancy-Ellen Haynes, Paul A. Kitos, Dale L. Boger, Stephen J. Benkovic
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:1839-1846
A set of inhibitors 3 and 4 of GAR and AICAR Tfase based on the TDAF core which contain an sp2 C-10 carbon atom replacing N-10 of the natural cofactor are detailed. Both possess electrophilic olefins and the potential of trapping the reacting amine o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8fa69c92d9bd85787eeb3715cbe9fe
https://doi.org/10.1016/s0968-0896(97)00122-3
https://doi.org/10.1016/s0968-0896(97)00122-3
Autor:
Joseph Ramcharan, Michael Karpusas, Haridasan V M Namboodiri, Young Hee Lee, Eric B. Springman, Marina Bukhtiyarova
Publikováno v:
Biochemistry. 49(17)
Protein kinases c-Abl, b-Raf, and p38alpha are recognized as important targets for therapeutic intervention. c-Abl and b-Raf are major targets of marketed oncology drugs Imatinib (Gleevec) and Sorafenib (Nexavar), respectively, and BIRB-796 is a p38a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa81c3ca704ccd2426c9aabc63023eea
https://pubmed.ncbi.nlm.nih.gov/20337484
https://pubmed.ncbi.nlm.nih.gov/20337484
Autor:
George Merkel, Mark Andrake, Anna Marie Skalka, Xue Zhi Zhao, Joseph Ramcharan, Terrence R. Burke
Publikováno v:
AIDS Research and Therapy
AIDS Research and Therapy, Vol 6, Iss 1, p 14 (2009)
AIDS Research and Therapy, Vol 6, Iss 1, p 14 (2009)
Background HIV-1 integrase (IN) is an attractive target for the development of drugs to treat AIDS, and inhibitors of this viral enzyme are already in the clinic. Nevertheless, there is a continuing need to devise new approaches to block the activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b564822086255752084f197e95fb8cdc
https://doi.org/10.1186/1742-6405-6-14
https://doi.org/10.1186/1742-6405-6-14
Publikováno v:
Retrovirology, Vol 3, Iss 1, p 34 (2006)
Retrovirology
Retrovirology
BackgroundTo further our understanding of the structure and function of HIV-1 integrase (IN) we developed and characterized a library of monoclonal antibodies (mAbs) directed against this protein. One of these antibodies, mAb33, which is specific for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741a99b95f7e569c6fce2d3221bfd6f3
https://doi.org/10.1186/1742-4690-3-34
https://doi.org/10.1186/1742-4690-3-34