Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Joseph R. Shaeffer"'
Autor:
Robert E. Cohen, Joseph R. Shaeffer
Publikováno v:
Annals of the New York Academy of Sciences. 850:394-397
Autor:
Robert E. Cohen, Joseph R. Shaeffer
Publikováno v:
Blood. 90:1300-1308
Two major causes of the anemia in β-thalassemia are a deficiency in hemoglobin (Hb) β-subunit (and consequently HbA) synthesis and, due to the resulting excess of Hb α-subunits, erythroid cell hemolysis. The hemolytic component might be ameliorate
Autor:
Mary A. Kania, Joseph R. Shaeffer
Publikováno v:
Biochemistry. 34:4015-4021
Ubiquitin-125I-alpha-globin conjugate fractions containing either one (Ub1-alpha), or two (Ub2-alpha), or a mixture of three and four (Ub3,4-alpha) molecules of ubiquitin (Ub), covalently linked to one 125I-alpha-globin molecule were isolated after i
Autor:
Robert E. Cohen, Joseph R. Shaeffer
Publikováno v:
Biochemistry. 35(33)
ATP-dependent proteolysis of 125I-labeled human alpha-globin, bovine alpha-lactalbumin, bovine serum albumin, or chicken lysozyme was assessed in a rabbit reticulocyte extract supplemented with ATP, excess ubiquitin, and variable amounts of ubiquitin
Autor:
Joseph R. Shaeffer
Publikováno v:
Journal of Biological Chemistry. 248:7473-7480
Hemoglobin Sabine (β91 Leu→Pro) is an unstable molecule present at low concentrations (12% of total hemoglobin) in the peripheral blood of one individual. The following results of structural studies demonstrated that hemoglobin Sabine existed pred
Publikováno v:
Journal of Biological Chemistry. 256:1727-1731
Publikováno v:
Biochemical and Biophysical Research Communications. 59:564-569
Summary Reticulocytes were isolated from the blood of eight nonanemic individuals with sickle cell trait; five donors had relatively low hemoglobin S concentrations (26 to 32%) and three had high hemoglobin S concentrations (40 to 42%). The cells wer
Publikováno v:
Journal of Biological Chemistry. 261:1111-1115
Dissociation of alpha beta and alpha gamma dimers of human hemoglobins (Hb) A and F into monomers was studied by alpha chain exchange (Shaeffer, J. R., McDonald, M. J., Turci, S. M., Dinda, D. M., and Bunn, H. F. (1984) J. Biol. Chem. 259, 14544-1454
Publikováno v:
Trends in Biochemical Sciences. 6:158-161
158 TIBS -June 1981 has been operationally separated into two distinct steps: an endonucleoytic cleavage of the pre-tRNA which produces the inter- vening sequence and two half-tRNA sized molecules and a ligation step in which the halves are joined to
Autor:
Joseph R. Shaeffer, Lewis C. Altenburg
Publikováno v:
Journal of Biological Chemistry. 249:2243-2248
Rabbit reticulocytes were pulse-labeled with [3H]leucine in a medium supporting protein synthesis in the absence or presence of 10-3 m hydroxylamine. When hydroxylamine was present, incorporation into soluble globin (primarily α chains) and α-hemog