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of 184
pro vyhledávání: '"Joseph R. Prohaska"'
Autor:
Danielle Bousquet-Moore, Joseph R. Prohaska, Eduardo A. Nillni, Traci Czyzyk, William C. Wetsel, Richard E. Mains, Betty A. Eipper
Publikováno v:
Neurobiology of Disease, Vol 37, Iss 1, Pp 130-140 (2010)
Mammalian genomes encode only a small number of cuproenzymes. The many genes involved in coordinating copper uptake, distribution, storage and efflux make gene/nutrient interactions especially important for these cuproenzymes. Copper deficiency and c
Externí odkaz:
https://doaj.org/article/882d7fbdcfca434eb67eec6e9c872671
Autor:
Thomas W. Bastian, Grant W. Anderson, Joseph R. Prohaska, Thu An Nguyen, Michael K. Georgieff, Stephanie Santarriaga
Publikováno v:
Nutritional Neuroscience. 18:365-375
Anemia caused by nutritional deficiencies, such as iron and copper deficiencies, is a global health problem. Iron and copper deficiencies have their most profound effect on the developing fetus/infant, leading to brain development deficits and poor c
Publikováno v:
Endocrinology. 155:1157-1167
Fetal/neonatal iron (Fe) and iodine/TH deficiencies lead to similar brain developmental abnormalities and often coexist in developing countries. We recently demonstrated that fetal/neonatal Fe deficiency results in a mild neonatal thyroidal impairmen
Autor:
Joseph R. Prohaska
Publikováno v:
Annals of the New York Academy of Sciences. 1314:1-5
Humans consume about 1 mg of copper daily, an amount thought adequate for most needs. Genetic, environmental, or physiological alterations can impose a higher copper set point, increasing risk for copper-limited pathophysiology. Humans express about
Copper-deficient Rats have Altered Plasma Dihydroxyphenylacetic acid and Spleen Catecholamine Levels
Autor:
Paul T. Teman, Joseph R. Prohaska
Publikováno v:
Nutritional neuroscience. 2(2)
Perinatal copper (Cu) deficiency was produced in month old female and male Sprague Dawley rats by beginning low Cu treatment at day 7 of gestation and continuing throughout lactation. Offspring were maintained on the treatment of their dams from post
Autor:
Joseph R. Prohaska
Publikováno v:
Metallomics : integrated biometal science. 8(9)
Autor:
Joseph R. Prohaska
Publikováno v:
Present Knowledge in Nutrition. :540-553
Autor:
Joseph R. Prohaska, Katie C. Lassi
Publikováno v:
The Journal of Nutrition. 142:292-297
A sensitive and reliable biomarker has yet to be identified for marginal copper deficiency in humans. The need for such a biomarker is critical, because increased cases of human copper deficiency evolve following bariatric surgery and other secondary
Autor:
Patricia M. Zerfas, Elisabeth J. Rushing, Anthony Donsante, Stephen G. Kaler, Jose A. Centeno, Ling Yi, Joseph R. Prohaska, Lauren R. Brinster, Patricia Sullivan, David S. Goldstein
Publikováno v:
Molecular Therapy. 19:2114-2123
Menkes disease is a lethal infantile neurodegenerative disorder of copper metabolism caused by mutations in a P-type ATPase, ATP7A. Currently available treatment (daily subcutaneous copper injections) is not entirely effective in the majority of affe
Publikováno v:
The Journal of Nutritional Biochemistry. 22:1084-1090
Copper, iron and iodine/thyroid hormone (TH) deficiencies disrupt brain development. Neonatal Cu deficiency causes Fe deficiency and may impact thyroidal status. One purpose of these studies was to determine the impact of improved iron status followi