Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Joseph R. O'Rourke"'
Autor:
Panayotis eThanos, Brendan H Clavin, John eHamilton, Joseph R O’Rourke, Thomas eMaher, Christopher eKoumas, Erick eMiao, Jessenia eLankop, Aya eElhage, Samir eHaj-Dahmane, Dale eDeutsch, Martin eKaczocha
Publikováno v:
Frontiers in Psychiatry, Vol 7 (2016)
Abstract:The therapeutic properties of cannabinoids have been well demonstrated but are overshadowed by such adverse effects as cognitive and motor dysfunction, as well as their potential for addiction. Recent research on the natural lipid ligands of
Externí odkaz:
https://doaj.org/article/bc4085c881eb4a47bee3c37d1cbaf6d2
Autor:
Nora D. Volkow, Aurelie Roux, Joseph R. O’Rourke, Panayotis K. Thanos, J. Albert Schultz, Shelley N. Jackson, Damon C. Barbacci, Amina S. Woods, Ludovic Muller, Carey D. Balaban
Publikováno v:
ACS Chem Neurosci
Alcohol abuse is a chronic disease characterized by the consumption of alcohol at a level that interferes with physical and mental health and causes serious and persistent changes in the brain. Lipid metabolism is of particular interest due to its hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9404ddf80576cf942eb24aa5c964ecf
https://doi.org/10.1021/acschemneuro.6b00120
https://doi.org/10.1021/acschemneuro.6b00120
Autor:
Mark S. Gold, Panayotis K. Thanos, Kenneth Blum, Marcelo Febo, Joseph R. O’Rourke, Anthony Napoli, Nora D. Volkow, John Hamilton
Publikováno v:
Oncotarget
Aging produces cellular, molecular, and behavioral changes affecting many areas of the brain. The dopamine (DA) system is known to be vulnerable to the effects of aging, which regulate behavioral functions such as locomotor activity, body weight, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62dce51d3ad0c305df5388c60ea14690
https://doi.org/10.18632/oncotarget.8088
https://doi.org/10.18632/oncotarget.8088
Autor:
Dimitris N. Metaxas, Panayotis K. Thanos, Joseph R. O’Rourke, Chiu Yin Lam, Christophe Restif
Publikováno v:
Journal of Neural Transmission. 124:3-11
Rodents are the most commonly used preclinical model of human disease assessing the mechanism(s) involved as well as the role of genetics, epigenetics, and pharmacotherapy on this disease as well as identifying vulnerability factors and risk assessme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e40edca5c08365c51efb0f4afa72c5
https://doi.org/10.1007/s00702-015-1487-0
https://doi.org/10.1007/s00702-015-1487-0
Autor:
Panayotis K. Thanos, Joseph R. O’Rourke, John Hamilton, Antonio Figueiredo, Dale G. Deutsch, Martin Kaczocha, Samir Haj-Dahmane, Steve Gonzalez, Brendan H. Clavin, Christopher Koumas, Matthew Marion
Publikováno v:
Behavioural pharmacology. 29(6)
Inhibition and genetic deletion of fatty acid-binding proteins (FABPs) 5 and 7 have been shown to increase the levels of the endocannabinoid anandamide as well as the related N-acylethanolamine's palmitoylethanolamide and oleoylethanolamide. This stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4abbcb90d0a5ba7b614b47d7a7173b
https://pubmed.ncbi.nlm.nih.gov/29570114
https://pubmed.ncbi.nlm.nih.gov/29570114
Autor:
Panayotis K. Thanos, Joseph R. O’Rourke, Virginia Womack, Kathrine Baldwin, Carey D. Balaban, J. Albert Schultz, Shelley N. Jackson, Nora D. Volkow, Amina S. Woods, Aurelie Roux, John G. Pagiazitis, Ludovic Muller
Publikováno v:
ACS Chemical Neuroscience
Ceramides (CER) are involved in alcohol-induced neuroinflammation. In a mouse model of chronic alcohol exposure, 16 CER and 18 sphingomyelin (SM) concentrations from whole brain lipid extracts were measured using electrospray mass spectrometry. All 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e21c67556ac8f9390db35c42ad343a
https://doi.org/10.1021/cn500174c
https://doi.org/10.1021/cn500174c
Autor:
Michelino Puopolo, Panayotis K. Thanos, Thomas Maher, John Hamilton, Joseph R. O’Rourke, Martin Kaczocha, Yuji Owada, Sherrye T. Glaser, Brendan Clavin, Mario J. Rebecchi
Publikováno v:
Molecular Pain
Background Fatty acid binding proteins (FABPs) serve as intracellular carriers that deliver endocannabinoids and N-acylethanolamines to their catabolic enzymes. Inhibition of FABPs reduces endocannabinoid transport and catabolism in cells and FABP in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf339839ec999992f52f1e329b70923
http://europepmc.org/articles/PMC4551694
http://europepmc.org/articles/PMC4551694