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pro vyhledávání: '"Joseph R. Norris"'
Autor:
Mohosin Sarkar, Christina Keventzidis Harsch, George T. Matic, Kathryn Hoffman, Joseph R. Norris, Tamara C. Otto, David E. Lenz, Douglas M. Cerasoli, Thomas J. Magliery
Publikováno v:
Journal of Lipids, Vol 2012 (2012)
Paraoxonase-1 (PON1) is a serum protein, the activity of which is related to susceptibility to cardiovascular disease and intoxication by organophosphorus (OP) compounds. It may also be involved in innate immunity, and it is a possible lead molecule
Externí odkaz:
https://doaj.org/article/35be391fb4584692816b53e50b774e5a
Publikováno v:
Chemico-biological interactions. 203(1)
Variants of human paraoxonase 1 (PON1) are being developed as catalytic bioscavengers for the organophosphorus chemical warfare agents (OP). It is preferable that the new PON1 variants have broad spectrum hydrolase activities to hydrolyze both G- and
Autor:
David E. Lenz, Douglas M. Cerasoli, Joseph R. Norris, Christina I. Keventzidis Harsch, George T. Matic, Kathryn Hoffman, Mohosin Sarkar, Thomas J. Magliery, Tamara C. Otto
Publikováno v:
Journal of Lipids
Journal of Lipids, Vol 2012 (2012)
Journal of Lipids, Vol 2012 (2012)
Paraoxonase-1 (PON1) is a serum protein, the activity of which is related to susceptibility to cardiovascular disease and intoxication by organophosphorus (OP) compounds. It may also be involved in innate immunity, and it is a possible lead molecule
Autor:
Douglas M. Cerasoli, Joseph R. Norris, Richard E. Sweeney, Brian J. Bahnson, Stephen D. Kirby
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. (12):1809-1815
Organophosphorus compounds (OPs) such as sarin and soman are some of the most toxic chemicals synthesized by man. They exert toxic effects by inactivating acetylcholinesterase (AChE) and bind secondary target protein. Organophosphorus compounds are h