Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Joseph R. Maxwell"'
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Celiac disease is a common immune-mediated disease characterized by abnormal T-cell responses to gluten. For many patients, symptoms and intestinal damage can be controlled by a gluten-free diet, but, for some, this approach is not enough, and celiac
Externí odkaz:
https://doaj.org/article/66cfb7aa56fe4972bedc28d76cc8ec56
Autor:
Crystal Morales Del Valle, Joseph R. Maxwell, Maria M. Xu, Antoine Menoret, Payal Mittal, Naomi Tsurutani, Adam J. Adler, Anthony T. Vella
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1434-1445.e3 (2019)
Summary: Chronic exposure to tumor-associated antigens inactivates cognate T cells, restricting the repertoire of tumor-specific effector T cells. This problem was studied here by transferring TCR transgenic CD4 T cells into recipient mice that const
Externí odkaz:
https://doaj.org/article/942b5316a64a413e811e6982067fb4b9
Autor:
Marissa Renardy, Alexander J. Prokopienko, Joseph R. Maxwell, Deborah A. Flusberg, Sahak Makaryan, Jangir Selimkhanov, Majid Vakilynejad, Kalyanasundaram Subramanian, Lucia Wille
Publikováno v:
Clinical Pharmacology & Therapeutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcdeee12b4c2c6d7d0a9d0999e086237
https://doi.org/10.1002/cpt.2952
https://doi.org/10.1002/cpt.2952
Autor:
Maria M. Xu, Naomi Tsurutani, Joseph R. Maxwell, Crystal Morales Del Valle, Anthony T. Vella, Payal Mittal, Antoine Ménoret, Adam J. Adler
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1434-1445.e3 (2019)
Summary: Chronic exposure to tumor-associated antigens inactivates cognate T cells, restricting the repertoire of tumor-specific effector T cells. This problem was studied here by transferring TCR transgenic CD4 T cells into recipient mice that const
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d142ca9a6289d57465503f240549c426
http://www.sciencedirect.com/science/article/pii/S2211124719304711
http://www.sciencedirect.com/science/article/pii/S2211124719304711
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Celiac disease is a common immune-mediated disease characterized by abnormal T-cell responses to gluten. For many patients, symptoms and intestinal damage can be controlled by a gluten-free diet, but, for some, this approach is not enough, and celiac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6884c6e919fda609706e316e8efca92b
https://pubmed.ncbi.nlm.nih.gov/33897715
https://pubmed.ncbi.nlm.nih.gov/33897715
Autor:
John A. Davis, Yu Zhang, James B. Rottman, Fergus R. Byrne, Jeannette Bigler, Alison L. Budelsky, Carole L. Smith, Antony Symons, Mike Fiorino, William A. Brown, Erin Stevens, Joseph R. Maxwell, Jennifer E. Towne
Publikováno v:
Immunity. 43(4):739-750
SummaryInterleukin-23 (IL-23) and IL-17 are cytokines currently being targeted in clinical trials. Although inhibition of both of these cytokines is effective for treating psoriasis, IL-12 and IL-23 p40 inhibition attenuates Crohn’s disease, wherea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5b9dc146ce130e7b12a123c458cd9f
Autor:
Keegan Cooke, Leslie J. Dickmann, Joseph R. Maxwell, Hongyan Li, Carole L. Smith, V. Kristina Perry, Carla Forte, Linh Tran, Tara Arvedson, James B. Rottman, Kimberly L. Merriam
Publikováno v:
The Journal of Immunology. 191:1845-1855
Iron is a trace element important for the proper folding and function of various proteins. Physiological regulation of iron stores is of critical importance for RBC production and antimicrobial defense. Hepcidin is a key regulator of iron levels with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3391608d1acb077662ed5ed9e2198a9c
https://doi.org/10.4049/jimmunol.1202716
https://doi.org/10.4049/jimmunol.1202716
Autor:
James B. Rottman, Katja Labitzke, Yang Li, Yingcai Wang, Jennifer E. Towne, Warren N. D'Souza, James A. Johnston, Hailing Hsu, Joseph R. Maxwell, Holger Beckmann, Angela Willee, Sharon X. Mu, Peter Jaeckel, Ralf Schwandner, Ming Zhang, Jason Douangpanya
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0180190 (2017)
PLoS ONE, Vol 12, Iss 7, p e0180190 (2017)
Inflammatory bowel disease (IBD) is associated with a loss of intestinal barrier function and dysregulated immune responses. It has been shown that short chain fatty acids (SCFAs) are protective in IBD and that GPR43 mediates the protective effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c24708b94267dea9b312b3659027e8
https://pubmed.ncbi.nlm.nih.gov/28727837
https://pubmed.ncbi.nlm.nih.gov/28727837
Autor:
Amy R. Weatherill, Joseph R. Maxwell, Andrew D. Weinberg, Anthony T. Vella, Chikara Takahashi
Publikováno v:
Cellular Immunology. 209:63-75
OX40 costimulates T cells, increases activated T cell longevity, and promotes memory acquisition. T cells activated in vivo with agonist anti-OX40 and ovalbumin have a unique pattern of survival and cell division compared to control cells, but are ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082761879c1b989ec2a8ac80fca0bcc7
https://doi.org/10.1006/cimm.2001.1783
https://doi.org/10.1006/cimm.2001.1783
Publikováno v:
Current Protocols in Pharmacology
Animal models of experimentally induced inflammatory bowel disease (IBD) are useful for understanding more about the mechanistic basis of disease, identifying new targets for therapeutic intervention, and testing novel therapeutic agents. This unit p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e97493b58b72d180f3abe50e19483af
https://pubmed.ncbi.nlm.nih.gov/22294404
https://pubmed.ncbi.nlm.nih.gov/22294404