Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Joseph R. Knoff"'
Autor:
Endri Karaj, Shaimaa H. Sindi, Nishanth Kuganesan, Radhika A. Koranne, Joseph R. Knoff, Antonisamy William James, Yu Fu, Lauren N. Kotsull, Mary Kay Pflum, Zahoor Shah, William R. Taylor, L. M. Viranga Tillekeratne
Publikováno v:
Journal of Medicinal Chemistry. 65:14764-14791
HDAC inhibitors are an attractive class of cytotoxic agents for the design of hybrid molecules. Several HDAC hybrids have emerged over the years, but none combines HDAC inhibition with ferroptosis, a combination which is being extensively studied bec
Autor:
Abdulateef Alqahtani, Ayad A. Al-Hamashi, Matthew Dunworth, Joseph R. Knoff, Robert A. Casero, Mary Kay H. Pflum, Lalith Perera, Endri Karaj, L. M. Viranga Tillekeratne, Radhika Koranne, Maisha S. Rashid, Samkeliso Dlamini, William R. Taylor
Publikováno v:
Bioorg Chem
Despite the advances in treatment strategies, cancer is still the second leading cause of death in the USA. A majority of the currently used cancer drugs have limitations in their clinical use due to poor selectivity, toxic side effects and multiple
Publikováno v:
European Journal of Medicinal Chemistry. 143:1790-1806
Histone deacetylase (HDAC) enzymes govern the post-translational acetylation state of lysine residues on protein substrates, leading to regulatory changes in cell function. Due to their role in cancers, HDAC proteins have emerged as promising targets
Autor:
Radhika Koranne, Mary Kay H. Pflum, Joseph R. Knoff, Samkeliso Dlamini, L. M. Viranga Tillekeratne, Ahmed T. Negmeldin, William R. Taylor, Ayad A. Al-Hamashi
Publikováno v:
Proceedings, Vol 22, Iss 1, p 63 (2019)
Epigenetic regulation of gene expression without changing DNA sequences is a promising strategy in developing therapeutic agents for human diseases, especially cancer. Histone deacetylases (HDACs) are a family of enzymes involved in epigenetic modula