Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Joseph R. Ghilardi"'
Autor:
Brian C Martinson, David Nelson, Emily Hagel-Campbell, David Mohr, Martin P Charns, Ann Bangerter, Carol R Thrush, Joseph R Ghilardi, Hanna Bloomfield, Richard Owen, James A Wells
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151571 (2016)
BACKGROUND:In service to its core mission of improving the health and well-being of veterans, Veterans Affairs (VA) leadership is committed to supporting research best practices in the VA. Recognizing that the behavior of researchers is influenced by
Externí odkaz:
https://doaj.org/article/18d7c82d28614ac18b57d344099efd15
Autor:
Gabriela Castañeda-Corral, Joseph R. Ghilardi, Juan Miguel Jimenez-Andrade, Michael A. Kuskowski, Patrick W. Mantyh
Publikováno v:
Pain. 152:2564-2574
Early, preemptive blockade of nerve growth factor (NGF)/tropomyosin receptor kinase A (TrkA) attenuates tumor-induced nerve sprouting and bone cancer pain. A critical unanswered question is whether late blockade of NGF/TrkA can attenuate cancer pain
Autor:
Michael A. Kuskowski, Joseph R. Ghilardi, Patrick W. Mantyh, Magdalena J. Kaczmarska, Reid N. Taylor, Katie T. Freeman, Kathleen A. Coughlin, Aaron P. Bloom, Juan Miguel Jimenez-Andrade, Gabriela Castañeda-Corral
Publikováno v:
The Journal of Pain. 12:698-711
Breast cancer metastasis to bone is frequently accompanied by pain. What remains unclear is why this pain tends to become more severe and difficult to control with disease progression. Here we test the hypothesis that with disease progression, sensor
Autor:
James Winkler, Patrice Lee, Joseph R. Ghilardi, David Trollinger, William G. Mantyh, Katie T. Freeman, Patrick W. Mantyh, Aaron P. Bloom, Juan Miguel Jimenez-Andrade, Michael A. Kuskowski, Steven W. Andrews, Karyn Bouhana
Publikováno v:
Bone. 48:389-398
Current therapies for treating skeletal pain have significant limitations as available drugs (non-steroidal anti-inflammatory drugs and opiates) have significant unwanted side effects. Targeting nerve growth factor (NGF) or its cognate receptor tropo
Autor:
Katie T. Freeman, Magdalena J. Kaczmarska, Joseph R. Ghilardi, Patrick W. Mantyh, Michael A. Kuskowski, Reid N. Taylor, James I. Stake, Aaron P. Bloom, Juan Miguel Jimenez-Andrade, William G. Mantyh
Publikováno v:
Neuroscience. 171:588-598
For many patients, pain is the first sign of cancer and, while pain can be present at any time, the frequency and intensity of pain tend to increase with advancing stages of the disease. Thus, between 75 and 90% of patients with metastatic or advance
Autor:
Michael A. Kuskowski, Reid N. Taylor, William G. Mantyh, James I. Stake, Aaron P. Bloom, Joseph R. Ghilardi, Katie T. Freeman, Patrick W. Mantyh, Juan Miguel Jimenez-Andrade
Publikováno v:
The Journal of Neuroscience. 30:14649-14656
Pain frequently accompanies cancer. What remains unclear is why this pain frequently becomes more severe and difficult to control with disease progression. Here we test the hypothesis that with disease progression, sensory nerve fibers that innervate
Autor:
Patrick W. Mantyh, Joseph R. Ghilardi, Aaron P. Bloom, William G. Mantyh, Michael A. Kuskowski, Juan Miguel Jimenez-Andrade, Katie T. Freeman
Publikováno v:
Molecular Pain
Molecular Pain, Vol 6, Iss 1, p 87 (2010)
Molecular Pain, Vol 6, Iss 1, p 87 (2010)
Pain often accompanies cancer and most current therapies for treating cancer pain have significant unwanted side effects. Targeting nerve growth factor (NGF) or its cognate receptor tropomyosin receptor kinase A (TrkA) has become an attractive target
Autor:
Nathan J. Koewler, Aaron P. Bloom, Juan Miguel Jimenez-Andrade, William G. Mantyh, Joseph R. Ghilardi, Michael A. Kuskowski, Patrick W. Mantyh, Katie T. Freeman, David Delong
Publikováno v:
Neuroscience. 162:1244-1254
Although skeletal pain can have a marked impact on a patient's functional status and quality of life, relatively little is known about the specific populations of peripheral nerve fibers that drive non-malignant bone pain. In the present report, neon
Autor:
Jerome F. Daanen, Joseph P. Mikusa, Chih Hung Lee, Chengmin Zhong, Jason A. Segreti, Patrick W. Mantyh, Torben R. Neelands, Patricia N. Banfor, Michael F. Jarvis, Arthur Gomtsyan, Prasant Chandran, Molly A. Sevcik, Philip R. Kym, Donna M. Gauvin, Regina M. Reilly, Kennan C. Marsh, Michael E. Kort, Connie R. Faltynek, James P. Sullivan, Erol K. Bayburt, Carol S. Surowy, Joseph R. Ghilardi, Prisca Honore, Gricelda Hernandez, Ryan M. Fryer, Shailen K. Joshi
Publikováno v:
Pain. 142:27-35
Transient receptor potential vanilloid type 1 (TRPV1) is a ligand-gated ion channel that functions as an integrator of multiple pain stimuli including heat, acid, capsaicin and a variety of putative endogenous lipid ligands. TRPV1 antagonists have be
Autor:
Joseph R. Ghilardi, Nathan J. Koewler, Carl D. Martin, Ryan J. Buus, Monica B Herrera, Michael A. Kuskowski, Patrick W. Mantyh, Katie T. Freeman, Juan Miguel Jimenez-Andrade
Publikováno v:
Anesthesiology. 108:473-483
Background Because of the relative lack of understanding of the mechanisms that drive skeletal pain, the purpose of this study was to adapt a previously validated closed femur fracture model to quantitatively evaluate skeletal pain in female and male