Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Joseph R. Couto"'
Publikováno v:
DNA and Cell Biology. 16:861-869
Lactadherin, a major glycoprotein of the human milk fat globule membrane, is abundant in human breast milk and expressed in human breast carcinomas. Previously, we have shown that the mature protein, formerly known as BA46, has three domains: an epid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c8009a9d435413b9e8402e280c97e3
https://doi.org/10.1089/dna.1997.16.861
https://doi.org/10.1089/dna.1997.16.861
Publikováno v:
DNA and Cell Biology. 15:281-286
The BA46 antigen of the human milk fat globule (HMFG) membrane is expressed in human breast carcinomas and has been used successfully as a target for experimental breast cancer radioimmunotherapy. To characterize this antigen further, we obtained the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565ec7e270536d59ce31ee0813af42f3
https://doi.org/10.1089/dna.1996.15.281
https://doi.org/10.1089/dna.1996.15.281
Publikováno v:
Hybridoma. 13:215-219
We have previously constructed a chimeric version of KC4G3, a murine antibody that reacts with several human epithelial cancers and binds to the human breast epithelial mucin. We have now successfully humanized KC4G3 using positional consensus data,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179684e5d0f7d89fc4709b89187c3cbb
https://doi.org/10.1089/hyb.1994.13.215
https://doi.org/10.1089/hyb.1994.13.215
Publikováno v:
Cell. 60:705-717
We previously described a dominant suppressor of the splicing defect conferred by an A----C intron branchpoint mutation in S. cerevisiae. Suppression occurs by increasing the frequency with which the mutant branchpoint is utilized. We have now cloned
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2053eda2131e4dbbb0dc712da52027c
https://doi.org/10.1016/0092-8674(90)90086-t
https://doi.org/10.1016/0092-8674(90)90086-t
Autor:
Kimberly-Anne Mattia, Moniquetta Hall, Sharon H. Willis, Manu Mabila, Rohan Keshwara, Joseph R. Couto, Joseph Rucker, Riley Payne, Cheryl Paes, Benjamin J. Doranz, Christine Rettew
Publikováno v:
Cancer Research. 75:656-656
Integral membrane proteins are important drug targets and monoclonal antibodies (MAbs) directed against them are highly sought for therapeutic purposes. However, the complex structure of membrane protein targets makes the discovery of these MAbs espe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73004bfd390f46124a207eb330b09130
https://doi.org/10.1158/1538-7445.am2015-656
https://doi.org/10.1158/1538-7445.am2015-656
Autor:
Yana Thaker, Anu Thomas, Joseph Rucker, Joseph R. Couto, Jason R. Goodman, Cheryl Paes, Melanie P. Wescott, Benjamin J. Doranz
Publikováno v:
Cancer Research. 75:2441-2441
Alanine (Ala) scanning is a widely used mutagenesis approach for systematic evaluation of protein function, which for large targets can be laborious and time-consuming. We have developed a platform technology, Shotgun Mutagenesis, for rapid and compr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72ad3f12aa26b4d3f688360bbb73a758
https://doi.org/10.1158/1538-7445.am2015-2441
https://doi.org/10.1158/1538-7445.am2015-2441
Autor:
Lars Linden, Khusru Asadullah, Sabine Wittemer-Rump, Matthew Nelson, Ulf Forssmann, Thomas Krahn, Joseph R. Couto, Joerg Willuda, Claudia Schneider, Yifei Zhu, Daniel Forler, Zhiming Liao, Alton Hiscox, Robert Pytela, Ricarda Finnern
Publikováno v:
Cancer Research. 74:2836-2836
C4.4a (LYPD3), a GPI-anchored cell surface protein, has been identified previously as a cancer- and metastasis-associated cell surface protein. It is expressed in a variety of cancer indications and, particularly, in the squamous cell subtype of non-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::331febcf2f8f3599685f78bfef8c8449
https://doi.org/10.1158/1538-7445.am2014-2836
https://doi.org/10.1158/1538-7445.am2014-2836
Autor:
Yifei Zhu, Alton Hiscox, Zhiming Liao, Robert C. Newton, James Hnatyszyn, Xiangdong Liu, Joseph R. Couto, Heather Gustafson
Publikováno v:
Journal of Clinical Oncology. 32:3043-3043
3043 Background: Indoleamine 2,3-dioxygenase-1 (IDO1) mediates oxidative cleavage of tryptophan, an amino acid essential for cell proliferation and survival. The depletion of tryptophan and the gen...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d19c92935e680647387b5e03b47a3ea
https://doi.org/10.1200/jco.2014.32.15_suppl.3043
https://doi.org/10.1200/jco.2014.32.15_suppl.3043
Publikováno v:
Hybridoma. 16(3)
In radioimmunotherapy, the long circulation times of antibody radioconjugates correlate with high relative radiation doses to nontumor tissues. Tumor/normal tissue ratios can be significantly improved by using targeting molecules with shorter circula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba56361fb613206b9d4246323d43626
https://pubmed.ncbi.nlm.nih.gov/9219034
https://pubmed.ncbi.nlm.nih.gov/9219034
Autor:
Jerry A. Peterson, Rosemarie B. Christian, R. Renae Speck, Joseph R. Couto, Roberto L. Ceriani, Simon G. Godwin, Radwan Kiwan
Publikováno v:
Molecular immunology. 33(14)
The IFab2 molecule described is expressed by a single gene construct that encodes the VH-CH1 and the Vk-Ck modules of a humanized version of the anti-breast cancer antibody BrE-3, joined via a short peptide linker. It can be shown that this basic gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95546804f62d86bfda98fe7d6051f8d7
https://pubmed.ncbi.nlm.nih.gov/9047375
https://pubmed.ncbi.nlm.nih.gov/9047375