Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Joseph R Taylor"'
Autor:
Ricardo A García, Debra J Search, John A Lupisella, Jacek Ostrowski, Bo Guan, Jian Chen, Wen-Pin Yang, Amy Truong, Aiqing He, Rongan Zhang, Mujing Yan, Samuel E Hellings, Peter S Gargalovic, Carol S Ryan, Linda M Watson, Robert A Langish, Petia A Shipkova, Nancy L Carson, Joseph R Taylor, Richard Yang, George C Psaltis, Thomas W Harrity, Jeffrey A Robl, David A Gordon
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e53192 (2013)
BACKGROUND: Chronic glucocorticoid excess has been linked to increased atherosclerosis and general cardiovascular risk in humans. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) increases active glucocorticoid levels within tissues by
Externí odkaz:
https://doaj.org/article/6bd68584051f4497b56fefb3bbb8522c
Autor:
Yan Shi, Ying Wang, Wei Meng, Robert P. Brigance, Denis E. Ryono, Scott Bolton, Hao Zhang, Sean Chen, Rebecca Smirk, Shiwei Tao, Joseph A. Tino, Kristin N. Williams, Richard Sulsky, Laura Nielsen, Bruce Ellsworth, Michael K. Y. Wong, Jung-Hui Sun, Leslie W. Leith, Dawn Sun, Dauh-Rurng Wu, Anuradha Gupta, Richard Rampulla, Arvind Mathur, Bang-Chi Chen, Aiying Wang, Helen G. Fuentes-Catanio, Lori Kunselman, Michael Cap, Jacob Zalaznick, Xiaohui Ma, Heng Liu, Joseph R. Taylor, Rachel Zebo, Beverly Jones, Stephen Kalinowski, Joann Swartz, Ada Staal, Kevin O’Malley, Lisa Kopcho, Jodi K. Muckelbauer, Stanley R. Krystek, Steven A. Spronk, Jovita Marcinkeviciene, Gerry Everlof, Xue-Qing Chen, Carrie Xu, Yi-Xin Li, Robert A. Langish, Yanou Yang, Qi Wang, Kamelia Behnia, Aberra Fura, Evan B. Janovitz, Nicola Pannacciulli, Steven Griffen, Bradley A. Zinker, John Krupinski, Mark Kirby, Jean Whaley, Robert Zahler, Joel C. Barrish, Jeffrey A. Robl, Peter T. W. Cheng
Publikováno v:
Journal of Medicinal Chemistry. 65:4291-4317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc68196d2f5ecc2fc360366195341ffb
https://doi.org/10.1021/acs.jmedchem.1c02110
https://doi.org/10.1021/acs.jmedchem.1c02110
Autor:
Brian J. Murphy, Daniel Smith, Julia Sapuppo, Giridhar S. Tirucherai, Lawrence J. Kennedy, Ching-Hsuen Chu, Anthony V. Azzara, Shiwei Tao, Glenn D. Rosen, Subramaniam Krishnananthan, Jun Li, Victor R. Guarino, Lisa Burns, Joseph R. Taylor, Milinda Ziegler, Lakshmi Sivaraman, Bruce A. Ellsworth, Selvakumar Kumaravel, Hao Zhang, Tao Wang, Jun Shi, Atsu Apedo, Dhanusu Suresh, Kathy Mosure, Gerry Everlof, David A. Gordon, Lisa Zhang, Michael Gill, Chen-Pin Hung, Jianqing Li, Peter T. W. Cheng, Robert F. Kaltenbach, Sutjano Jusuf, Ying Wang, Stephanie Boehm, Mary Ellen Cvijic, Matthew G. Soars, Chi Shing Sum, Yan Shi, Jeffrey A. Robl, Reddigunta Ramesh Babu, Bradley A. Zinker, Yanou Yang, Stephen S. Kalinowski, Carrie Xu, Steven J. Walker, Sarah C. Traeger, Rebekah Heiry, Kimberley A. Lentz, Qian Ruan
Publikováno v:
Journal of Medicinal Chemistry. 64:15549-15581
The oxycyclohexyl acid BMS-986278 (33) is a potent lysophosphatidic acid receptor 1 (LPA1) antagonist, with a human LPA1 Kb of 6.9 nM. The structure-activity relationship (SAR) studies starting from the LPA1 antagonist clinical compound BMS-986020 (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c00ce908946d21bafba2486eb2e08c90
https://doi.org/10.1021/acs.jmedchem.1c01256
https://doi.org/10.1021/acs.jmedchem.1c01256
Autor:
Carl G. Jones, Vikash Tatayah, Ken Norris, Caroline M. Wainwright, Malcolm A. C. Nicoll, Emily Black, Joseph R. Taylor, Pier Luigi Vidale
Publikováno v:
Climatic Change. 164
Constraints on evolutionary adaptation and range shifts mean that phenotypic plasticity, which includes physiological, developmental or behavioural responses to environmental conditions, could be an important mode of adaptation to a changing climate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3730c9dab35a6e99c40f04fc3dcc1d53
https://doi.org/10.1007/s10584-021-02971-y
https://doi.org/10.1007/s10584-021-02971-y
Autor:
Michael Gill, Matt Soars, Robert F. Kaltenbach, Mosure Kathy, Peter T. W. Cheng, Anthony V. Azzara, Stephen S. Kalinowski, Shiwei Tao, Chen-Pin Hung, Larry Kennedy, Yan Shi, Lisa Burns, Julia Sapuppo, Tao Wang, David A. Gordon, Roble Jeffrey, Cvijic Mary-Ellen, Hao Zhang, Ching-Hsuen Chu, Reddigunta Ramesh Babu, Jun Shi, Bruce A. Ellsworth, Jun Li, Bradley A. Zinker, Brian J. Murphy, Dhanusu Suresh, Joseph R. Taylor, Ying Wang, Chi-Shing Sum, Ziegler Milinda, Rebekah Heiry, Steve Walker, Stephanie Boehm
Publikováno v:
Idiopathic interstitial pneumonias.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal fibrosing lung disease with limited approved treatment options. The bioactive lysophospholipid lysophosphatidic acid (LPA) and the LPA1 receptor have been implicated in the etiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b54aea41cff0b233b97a0c88ca4d9ae
https://doi.org/10.1183/13993003.congress-2019.pa5383
https://doi.org/10.1183/13993003.congress-2019.pa5383
Autor:
Paul E. Morin, Haixia Wang, Lawrence J. Kennedy, Stephen P. O'connor, James J. Li, Akbar Nayeem, Vidhyashankar Ramamurthy, Steven Sheriff, Nathan Morgan, Steven J. Walker, Xiang-Yang Ye, Frederick Moulin, Brad D. Maxwell, Thomas Harrity, Jeffrey A. Robl, Stephanie Y. Chen, Timothy W. Harper, Rachel Zebo, Jun Li, Zhenqiu Hong, Shung Wu, Mengmeng Wang, Randolph P. Ponticiello, David A. Gordon, Rajasree Golla, Ramakrishna Seethala, Daniel M. Camac, Joseph R. Taylor, David S. Yoon
[Image: see text] BMS-823778 (2), a 1,2,4-triazolopyridinyl-methanol derived analog, was identified as a potent and selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) enzyme (IC(50) = 2.3 nM) with >10,000-fold selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537bf023154f9aff48423a9bc7df61b2
https://europepmc.org/articles/PMC6295842/
https://europepmc.org/articles/PMC6295842/
Autor:
Steven J. Walker, Vidyhashankar Ramamurthy, Jun Li, Shung Wu, David K. Leahy, John D. Dimarco, Brad D. Maxwell, Daniel M. Camac, Joseph R. Taylor, Akbar Nayeem, Zhiwei Guo, James J. Li, Xiang-Yang Ye, Frederick Moulin, Paul E. Morin, Stepen P O’Connor, Haixia Wang, Jeffrey A. Robl, Rachel Zebo, Mark S. Kirby, Thomas Harrity, Joel C. Barrish, Timothy W. Harper, Lawrence L Kennedy, Rajasree Golla, Atsu Apedo, Bogdan Sleczka, Yi-Xin Li, David S. Yoon, Bin He, Steven Sheriff, Ramakrishna Seethala, Nathan Morgan, Mengmeng Wang, Randolph P. Ponticiello, Raymond P. Scaringe, Stephanie Y. Chen, Jianqing Li, Zhenqiu Hong, Ronald L. Hanson, David A. Gordon
Publikováno v:
Journal of medicinal chemistry. 60(12)
BMS-816336 (6n-2), a hydroxy-substituted adamantyl acetamide, has been identified as a novel, potent inhibitor against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme (IC50 3.0 nM) with >10000-fold selectivity over human 11β-hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86602b708c78e42f5648acb482b306b
https://pubmed.ncbi.nlm.nih.gov/28537398
https://pubmed.ncbi.nlm.nih.gov/28537398
Autor:
Ramakrishna Seethala, Steven J. Walker, Jun Li, Stephen P. O'connor, Lawrence J. Kennedy, Steven Sheriff, Rachel Zebo, Daniel M. Camac, Paul E. Morin, Jeffrey A. Robl, Joseph R. Taylor, James J. Li, Haixia Wang, Thomas Harrity, David A. Gordon, Akbar Nayeem, Timothy W. Harper, Zhenqiu Hong, Mengmeng Wang, Randolph P. Ponticiello, Rajasree Golla, Nathan Morgan
Publikováno v:
ACS Medicinal Chemistry Letters. 5:803-808
Small alkyl groups and spirocyclic-aromatic rings directly attached to the left side and right side of the 1,2,4-triazolopyridines (TZP), respectively, were found to be potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase-type 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f50571624276edc8a5db39e2719422c
https://doi.org/10.1021/ml500144h
https://doi.org/10.1021/ml500144h
Autor:
Claudio Mapelli, Ramakrishna Seethala, Songping Han, Ellen Sieber-McMaster, William R. Ewing, Ashish Khanna, Keith L. Constantine, Douglas James Riexinger, Daniel Longhi, John Krupinski, Zhengping Ma, Constance Smith-Monroy, Bastos Margarita M, Dan Shi, Michael S. Bernatowicz, Joseph R. Taylor, Christine Huang, Rajasree Golla, Gordon William Robinson, Jelka Pluscec, Jean M. Whaley, Sesha Natarajan, Jean-Philippe Meyer, Robert H. Stoffel, Li Xin, Ving G. Lee, Barry Koplowitz, Cecilia L Chi, Ildiko Antal-Zimanyi
Publikováno v:
Journal of Medicinal Chemistry. 52:7788-7799
Glucagon-like peptide 1 (GLP-1) is a 30 or 31 amino acid peptide hormone that contributes to the physiological regulation of glucose homeostasis and food intake. Herein, we report the discovery of a novel class of 11 amino acid GLP-1 receptor agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59d43fbd51aab4facd89ceaa788aab6
https://doi.org/10.1021/jm900752a
https://doi.org/10.1021/jm900752a
Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats
Autor:
John R. Wetterau, Deborah Hagan, William N. Washburn, Wei Meng, Joseph R. Taylor, Songping Han, Scott A. Biller, Jean M. Whaley, Li Xin
Publikováno v:
Diabetes. 57:1723-1729
OBJECTIVE—The inhibition of gut and renal sodium-glucose cotransporters (SGLTs) has been proposed as a novel therapeutic approach to the treatment of diabetes. We have identified dapagliflozin as a potent and selective inhibitor of the renal sodium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5864104a49101cfc9c6b52636c8afe
https://doi.org/10.2337/db07-1472
https://doi.org/10.2337/db07-1472