Zobrazeno 1 - 10 of 49 pro vyhledávání: '"Joseph R Stimers"'
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Akademický článek
Overexpression of the Large-Conductance, Ca2+-Activated K+ (BK) Channel Shortens Action Potential Duration in HL-1 Cardiomyocytes.
Autor: Joseph R Stimers, Li Song, Nancy J Rusch, Sung W Rhee
Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0130588 (2015)
Long QT syndrome is characterized by a prolongation of the interval between the Q wave and the T wave on the electrocardiogram. This abnormality reflects a prolongation of the ventricular action potential caused by a number of genetic mutations or a
Externí odkaz: https://doaj.org/article/e074ea4c1c8d454d893a8f9aa00d99fb
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2
Comparison of metabolic and neuropathy profiles of rats with streptozotocin-induced overt and moderate insulinopenia
Autor: Jing Wang, Dmitry Romanovsky, Joseph R. Stimers, Maxim Dobretsov, Elie D. Al-Chaer
Publikováno v: Neuroscience. 170:337-347
To assess the relative roles of insulinopenia, hyperglycemia and dyslipidemia in pathogenesis of diabetic neuropathy, we compared plasma insulin, glucose and lipid metabolism and peripheral nerve function in rats with streptozotocin (STZ) – induced
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea917a431884396ad2f0aeb53d3cf257
https://doi.org/10.1016/j.neuroscience.2010.06.059
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3
Tumor Necrosis Factor-α Suppresses Sustained Potassium Currents in Rat Small Diameter Sensory Neurons
Autor: Bao-Gang Liu, Maxim Dobretsov, Jun-Ming Zhang, Joseph R. Stimers
Publikováno v: The Open Pain Journal. 1:1-7
Tumor necrosis factor- (TNF- ), a pro-inflammatory cytokine, produces pain and hyperalgesia by activating and/or sensitizing nociceptive sensory neurons. In the present study, using whole-cell patch clamp techniques, the regulation of potassium
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e75988ff1168a31eacd6c8e1ad0c0194
https://doi.org/10.2174/1876386300902010001
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4
Design of Mutant β2Subunits as Decoy Molecules to Reduce the Expression of Functional Ca2+Channels in Cardiac Cells
Autor: Sabine Telemaque, James D. Marsh, Terrie Grain, Nancy J. Rusch, Sung W. Rhee, Swapnil K. Sonkusare, Joseph R. Stimers
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 325:37-46
Calcium influx through long-lasting ("L-type") Ca(2+) channels (Ca(V)) drives excitation-contraction in the normal heart. Dysregulation of this process contributes to Ca(2+) overload, and interventions that reduce expression of the pore-forming alpha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f3dcffa8d0f32e2f811688a7c63d87
https://doi.org/10.1124/jpet.107.128215
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7
Relevance of hyperglycemia to early mechanical hyperalgesia in streptozotocin-induced diabetes
Autor: Stephanie L. Hastings, Joseph R. Stimers, Maxim Dobretsov, Dmitry Romanovsky
Publikováno v: Journal of the Peripheral Nervous System. 9:62-69
A modified von Frey filament test and an algesiometer paw pressure test were used to measure mechanical nociceptive withdrawal thresholds of the hind limb of control rats and rats injected with streptozotocin (STZ, 50 mg/kg). STZ treatment induced hy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7cb2a5add791f18b15ba2f3f498988b
https://doi.org/10.1111/j.1085-9489.2004.009204.x
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8
Stretch receptor-associated expression of α3 isoform of the na+,k+-atpase in rat peripheral nervous system
Autor: Dmitry Romanovsky, T.J Sims, Stephanie L. Hastings, Joseph R. Stimers, Maxim Dobretsov
Publikováno v: Neuroscience. 116:1069-1080
Expression of the neuronal alpha(3) isoform of the Na(+),K(+)-ATPase (alpha(3) Na(+),K(+)-ATPase) was studied in the rat peripheral nervous system using histological and immunohistochemical techniques. Non-uniform expression of the alpha(3) Na(+),K(+
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd05b9eeb8f1e38d3740cf61ac825ce
https://doi.org/10.1016/s0306-4522(02)00922-3
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9
Differential Effects of Linoleic Acid Metabolites on Cardiac Sodium Current
Autor: Joseph R. Stimers, Maddison D. Harrell
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 303:347-355
9,10-Epoxy-12-octadecenoic acid (EOA), a metabolite of linoleic acid, causes cardiac arrest in dogs. Other metabolites of linoleic acid also have toxic effects. This study investigates the mechanism of action of four of these compounds on cardiac Na(
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238daf9b644a125c326c5b318c988c23
https://doi.org/10.1124/jpet.102.038166
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10
Doxorubicin inhibits lymphatic function in vitro and in vivo (655.1)
Autor: Rachel Versluis, Nancy J. Rusch, Asif R. Pathan, Amanda J. Stolarz, Ekaterina I. Galanzha, Joseph R. Stimers, Terry W. Fletcher
Publikováno v: The FASEB Journal. 28
Doxorubicin (DOX) is an independent risk factor for lymphedema in breast cancer patients after surgery and/or radiation therapy. The mechanisms by which DOX contributes to lymphedema are unclear. W...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c745d72efef3c14eb683efc875300a43
https://doi.org/10.1096/fasebj.28.1_supplement.655.1
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