Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Joseph R Burgoyne"'
Autor:
Dagmar J Haeussler, Alicia M Evangelista, Joseph R Burgoyne, Richard A Cohen, Markus M Bachschmid, David R Pimental
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23160 (2011)
Adenoviruses are widely used for overexpressing proteins in primary mammalian cells. Incorporation of the early viral gene, E1A, or viral cross-contamination can occur during amplification, and identification of these products is crucial as the trans
Externí odkaz:
https://doaj.org/article/68126fb7c4bc4e34b0120abaed92c0b7
Autor:
Maithily S. Nanadikar, Ana M. Vergel Leon, Jia Guo, Gijsbert J. van Belle, Aline Jatho, Elvina S. Philip, Astrid F. Brandner, Rainer A. Böckmann, Runzhu Shi, Anke Zieseniss, Carla M. Siemssen, Katja Dettmer, Susanne Brodesser, Marlen Schmidtendorf, Jingyun Lee, Hanzhi Wu, Cristina M. Furdui, Sören Brandenburg, Joseph R. Burgoyne, Ivan Bogeski, Jan Riemer, Arpita Chowdhury, Peter Rehling, Tobias Bruegmann, Vsevolod V. Belousov, Dörthe M. Katschinski
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Redox signaling and cardiac function are tightly linked. However, it is largely unknown which protein targets are affected by hydrogen peroxide (H2O2) in cardiomyocytes that underly impaired inotropic effects during oxidative stress. Here, w
Externí odkaz:
https://doaj.org/article/46b0dc091943496094992a4e0a96de5f
Autor:
Joseph R. Burgoyne, Philip Eaton
Publikováno v:
Sensors, Vol 10, Iss 4, Pp 2731-2751 (2010)
The control of vascular smooth muscle contractility enables regulation of blood pressure, which is paramount in physiological adaptation to environmental challenges. Maintenance of stable blood pressure is crucial for health as deregulation (caused b
Externí odkaz:
https://doaj.org/article/cfa730bebecf4b7abcf4bd07c53e0f71
Autor:
Oleksandra, Prysyazhna, Kathryn, Wolhuter, Christopher, Switzer, Celio, Santos, Xiaoping, Yang, Steven, Lynham, Ajay M, Shah, Philip, Eaton, Joseph R, Burgoyne
Publikováno v:
Circulation
Prysyazhna, O, Wolhuter, K, Switzer, C H, Santos, C, Yang, X, Lynham, S, Shah, A M, Eaton, P & Burgoyne, J 2019, ' Blood pressure-lowering by the antioxidant resveratrol is counterintuitively mediated by oxidation of cGMP-dependent protein kinase ', Circulation, vol. 140, no. 2, pp. 126–137 . https://doi.org/10.1161/CIRCULATIONAHA.118.037398
Prysyazhna, O, Wolhuter, K, Switzer, C H, Santos, C, Yang, X, Lynham, S, Shah, A M, Eaton, P & Burgoyne, J 2019, ' Blood pressure-lowering by the antioxidant resveratrol is counterintuitively mediated by oxidation of cGMP-dependent protein kinase ', Circulation, vol. 140, no. 2, pp. 126–137 . https://doi.org/10.1161/CIRCULATIONAHA.118.037398
Supplemental Digital Content is available in the text.
Background: The health-promoting and disease-limiting abilities of resveratrol, a natural polyphenol, has led to considerable interest in understanding the mechanisms of its therapeutic acti
Background: The health-promoting and disease-limiting abilities of resveratrol, a natural polyphenol, has led to considerable interest in understanding the mechanisms of its therapeutic acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::822b5cae90c65dc55eb80b7a3dd491d6
http://europepmc.org/articles/PMC6635045
http://europepmc.org/articles/PMC6635045
Autor:
Joseph R. Burgoyne, Angeliki Ntorla
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Histone crotonylation is a newly identified epigenetic modification that has a pronounced ability to regulate gene expression. It belongs to an expanding group of short chain lysine acylations that also includes the extensively studied mark histone a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767429246967c2da8a4e3aeb8549556e
https://doi.org/10.3389/fcell.2021.624914
https://doi.org/10.3389/fcell.2021.624914
Publikováno v:
Hypertension (Dallas, Tex. : 1979)
Supplemental Digital Content is available in the text.
Arterial hypertension continues to be a major health burden. Development of new antihypertensive drugs that engage vasodilatory mechanisms not harnessed by available therapies offer therapeu
Arterial hypertension continues to be a major health burden. Development of new antihypertensive drugs that engage vasodilatory mechanisms not harnessed by available therapies offer therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2506ac1ca55a26998bba4c548aca27ee
http://europepmc.org/articles/PMC5548503
http://europepmc.org/articles/PMC5548503
Autor:
Christopher H. Switzer, Joseph R. Burgoyne, Philip Eaton, Tony Ng, Hyun-Ju Cho, Rebecca L. Charles, Alisa Kamynina, Olena Rudyk
Publikováno v:
Redox Biology
Redox Biology, Vol 29, Iss, Pp-(2020)
Redox Biology, Vol 29, Iss, Pp-(2020)
Nitro-oleate (10-nitro-octadec-9-enoic acid), which inhibits soluble epoxide hydrolase (sEH) by covalently adducting to C521, increases the abundance of epoxyeicosatrienoic acids (EETs) that can be health promoting, for example by lowering blood pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dac4632aa719d9dcf3693afe389ee6a
http://europepmc.org/articles/PMC6928308
http://europepmc.org/articles/PMC6928308
Autor:
Oleksandra Prysyazhna, Joseph R. Burgoyne, Christopher H. Switzer, Steven Lynham, Xiaoping Yang, Ajay M. Shah, Kathryn Wolhuter, Celio X.C. Santos, Philip Eaton
Publikováno v:
Circulation. 140(22)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08130e75eddf7193f738a781b1936bd
https://pubmed.ncbi.nlm.nih.gov/31765253
https://pubmed.ncbi.nlm.nih.gov/31765253
Autor:
David A. Kass, Oleksandra Prysyazhna, Jenna Scotcher, Steven P. Grover, Joseph R. Burgoyne, Philip Eaton
Publikováno v:
Prysyazhna, O, Burgoyne, J R, Scotcher, J, Grover, S, Kass, D & Eaton, P 2016, ' Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation ', Journal of Biological Chemistry, vol. 291, no. 33, pp. 17427-17436 . https://doi.org/10.1074/jbc.M116.724070
Phosphodiesterase 5 (PDE5) inhibitors limit myocardial injury caused by stresses, including doxorubicin chemotherapy. cGMP binding to PKG Iα attenuates oxidant-induced disulfide formation. Because PDE5 inhibition elevates cGMP and protects from doxo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a111c143614d85c22e26a2a6102b1a
https://doi.org/10.1074/jbc.m116.724070
https://doi.org/10.1074/jbc.m116.724070
Autor:
Katsuhiko Ono, Mizanur Rahaman, Shigemoto Fujii, Hiroyasu Tsutsuki, Philip Eaton, Tomohiro Sawa, Oleksandra Prysyazhna, Takaaki Akaike, Yuichi Oike, Khandaker Ahtesham Ahmed, Soichiro Akashi, Eiji Horio, Joseph R. Burgoyne, Tomoaki Ida
Publikováno v:
Biochemistry. 55:751-761
8-Nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP) is a nitrated derivative of guanosine 3',5'-cyclic monophosphate (cGMP) formed endogenously under conditions associated with production of both reactive oxygen species and nitric oxide. It ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06680742ef57dcb573f8150ca04d7210
https://doi.org/10.1021/acs.biochem.5b00774
https://doi.org/10.1021/acs.biochem.5b00774