Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joseph R Albe"'
Autor:
Cynthia M McMillen, Devin A Boyles, Stefan G Kostadinov, Ryan M Hoehl, Madeline M Schwarz, Joseph R Albe, Matthew J Demers, Amy L Hartman
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 10, p e0010898 (2022)
Rift Valley fever (RVF) is a disease of animals and humans associated with abortions in ruminants and late-gestation miscarriages in women. Here, we use a rat model of congenital RVF to identify tropisms, pathologies, and immune responses in the plac
Externí odkaz:
https://doaj.org/article/252dffdec9d24454814de48ee8408d52
Autor:
Henry Ma, Joseph R Albe, Theron Gilliland, Cynthia M McMillen, Christina L Gardner, Devin A Boyles, Emily L Cottle, Matthew D Dunn, Jeneveve D Lundy, Noah Salama, Katherine J O'Malley, Ivona Pandrea, Tobias Teichert, Stacey Barrick, William B Klimstra, Amy L Hartman, Douglas S Reed
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1009946 (2022)
Venezuelan equine encephalitis virus (VEEV) is a positively-stranded RNA arbovirus of the genus Alphavirus that causes encephalitis in humans. Cynomolgus macaques are a relevant model of the human disease caused by VEEV and are useful in exploring pa
Externí odkaz:
https://doaj.org/article/a9ae6f80485742ccbbc0ae30019f063d
Autor:
Joseph R Albe, Henry Ma, Theron H Gilliland, Cynthia M McMillen, Christina L Gardner, Devin A Boyles, Emily L Cottle, Matthew D Dunn, Jeneveve D Lundy, Katherine J O'Malley, Noah Salama, Aaron W Walters, Ivona Pandrea, Tobias Teichert, William B Klimstra, Douglas S Reed, Amy L Hartman
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009308 (2021)
Aerosol exposure to eastern equine encephalitis virus (EEEV) can trigger a lethal viral encephalitis in cynomolgus macaques which resembles severe human disease. Biomarkers indicative of central nervous system (CNS) infection by the virus and lethal
Externí odkaz:
https://doaj.org/article/148107b18d2d4b4295040268973f0ef0
Autor:
Amy L Hartman, Sham Nambulli, Cynthia M McMillen, Alexander G White, Natasha Louise Tilston-Lunel, Joseph R Albe, Emily Cottle, Matthew D Dunn, L James Frye, Theron H Gilliland, Emily L Olsen, Katherine J O'Malley, Madeline M Schwarz, Jaime A Tomko, Reagan C Walker, Mengying Xia, Matthew S Hartman, Edwin Klein, Charles A Scanga, JoAnne L Flynn, William B Klimstra, Anita K McElroy, Douglas S Reed, W Paul Duprex
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008903 (2020)
Vaccines are urgently needed to combat the global coronavirus disease 2019 (COVID-19) pandemic, and testing of candidate vaccines in an appropriate non-human primate (NHP) model is a critical step in the process. Infection of African green monkeys (A
Externí odkaz:
https://doaj.org/article/9af9b959abac4308b999b6e2d34961ea
Autor:
Joseph R Albe, Devin A Boyles, Aaron W Walters, Michael R Kujawa, Cynthia M McMillen, Douglas S Reed, Amy L Hartman
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007833 (2019)
Rift Valley fever virus (RVFV) causes severe disease in livestock concurrent with zoonotic transmission to humans. A subset of people infected with RVFV develop encephalitis, and significant gaps remain in our knowledge of how RVFV causes pathology i
Externí odkaz:
https://doaj.org/article/e0c25f150c4c4c20910536b32320f6cd
Autor:
Dominique J. Barbeau, Joseph R. Albe, Sham Nambulli, Natasha L. Tilston-Lunel, Amy L. Hartman, Seema S. Lakdawala, Ed Klein, W. Paul Duprex, Anita K. McElroy
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
ABSTRACT Rift Valley fever virus (RVFV) is a pathogen of both humans and livestock in Africa and the Middle East. Severe human disease is associated with hepatitis and/or encephalitis. Current pathogenesis studies rely on rodents and nonhuman primate
Externí odkaz:
https://doaj.org/article/a37141366b9f4ea5a5bc7702a5492d20
Autor:
Madeline M. Schwarz, Kaleigh A. Connors, Katherine A. Davoli, Cynthia M. McMillen, Joseph R. Albe, Ryan M. Hoehl, Matthew J. Demers, Safder S. Ganaie, David A. Price, Daisy W. Leung, Gaya K. Amarasinghe, Anita K. McElroy, Douglas S. Reed, Amy L. Hartman
Publikováno v:
Journal of virology. 96(20)
People infected with the mosquito-borne Rift Valley fever virus (RVFV) can suffer from eye-related problems resulting in ongoing vision issues or even permanent blindness. Despite ocular disease being the most frequently reported severe outcome, it i
Autor:
Cynthia M. McMillen, Devin A. Boyles, Stefan G. Kostadinov, Ryan M. Hoehl, Madeline M. Schwarz, Joseph R. Albe, Matthew J. Demers, Amy L. Hartman
Rift Valley fever (RVF) is a disease of animals and humans associated with abortions in ruminants and, more recently, late-gestation miscarriages in African women. Here, we use a rat model of congenital RVF to identify cellular tropism, pathology, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e01f781a370b3ba417fd9357e7ad963
https://doi.org/10.1101/2022.02.25.481831
https://doi.org/10.1101/2022.02.25.481831
Autor:
Austin B. Moyle, Daisy W. Leung, Safder Ganaie, Michael R. Kujawa, Devin A. Boyles, Xiaoxia Cui, Takeshi Egawa, Aidan R. Cole, David A. Price, Wenjie Wang, Monica F. Sentmanat, Michael L. Gross, Ryan M. Hoehl, Herbert W. Virgin, Gaya K. Amarasinghe, Sachdev S. Sidhu, Amy L. Hartman, John G. Doench, Cynthia M. McMillen, Anita K. McElroy, Annie X. Feng, Matthew Demers, Sean P. J. Whelan, Joan Teyra, Tom J. Brett, Anthony Orvedahl, Shane Miersch, Nawneet Mishra, Joseph R. Albe, Madeline M. Schwarz, Nicole D. Wagner, Zachary T. Koenig, Lia Cardarelli, Sarah H. Stubbs
Publikováno v:
Cell
Rift Valley Fever Virus (RVFV) is a zoonotic pathogen with pandemic potential. RVFV entry is mediated by the viral glycoprotein (Gn), but host entry factors remain poorly defined. Our genome-wide CRISPR screen identified low-density lipoprotein recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4526e72964ff21055ddcb4d8d6c2fff1
https://europepmc.org/articles/PMC8786218/
https://europepmc.org/articles/PMC8786218/
Autor:
Katherine J. O’Malley, Joseph R. Albe, Matthew D. Dunn, Emily L. Cottle, Cynthia M. McMillen, Ivona Pandrea, Henry Ma, Noah Salama, William B. Klimstra, Tobias Teichert, Stacey Barrick, Theron Gilliland, Jeneveve D. Lundy, Douglas S. Reed, Devin A. Boyles, Christina L. Gardner, Amy L. Hartman
Publikováno v:
PLoS pathogens. 18(6)
Venezuelan equine encephalitis virus (VEEV) is a positively-stranded RNA arbovirus of the genus Alphavirus that causes encephalitis in humans. Cynomolgus macaques are a relevant model of the human disease caused by VEEV and are useful in exploring pa